The purpose of this exploratory study was to examine whether demographic and disability variables predict total health care expenditure of Wisconsin PROMISE. The findings are intended to assist in promoting cost-effectiveness for future similar initiates. This study data were extracted from Wisconsin PROMISE data set. This study had a total of 1,443 youth with disabilities ( Mage = 14.89). The majority of participants were male (69%). Our results indicated that some demographic and disability–related characteristics are associated with total health care expenditure in control with VR case during PROMISE, control without VR case during PROMISE, and treatment group. Overall, findings of the current study suggest demographic and disability variables do assist in predicting total health care expenditure of Wisconsin PROMISE.