There is an unprecedented pressure that both individuals and businesses endure, especially when considering changes and challenges brought by the COVID-19 pandemic and the COVID-19 crisis. Mindfulness seems to become an integrated part of people's lives, in the attempt to be more concentrated on their daily tasks, more focused on living in the present moment, more determined to eliminate anxiety and stress. In like manner, mindfulness in business seems to become a key solution to stronger entrepreneurship and highly successful workplace relationships. Thus, the new economy, the knowledge-based economy, centers its attention on the powerful links and opportunities that may be encountered between well-being, mental health, and mindfulness, seeking a way to create valuable mindfulness business principles, capable of producing outstanding results, empowering people, facilitating cooperation, allowing good governance, inducing corporate social responsibility, fostering community connections, enabling competitiveness, and supporting sustainability, development, and environmental balance.