Bifurcating the dynamic dominant logic: technical and evolutionary patterns of action

PurposeThis study proposed the integrative model of dynamic dominant logic (DL) with exploitation (EP) and exploration (ER) as a pattern of actions in endeavoring firm performance (FP). This study also intended to explain the multiple patterns of DL in creating technical and evolutionary fitness simultaneously.Design/methodology/approachThis study used a cross-sectional quantitative analysis of the Indonesian commercial banking population facing digital transformation and was analyzed using covariance-based structural equation modeling through parceling.FindingsThe model confirmed that DL positively affects EP and ER. It also revealed that DL indirectly impacts FP through EP, indicating changes in the traditional banking business through the strong acceptance of “new realities” in adapting to the rapid growth of technology. Hence, this study discovered that during the recent banking digital transformation, the beneficial inertia of the technical pattern of action might lose effectiveness in creating superior performance.Practical implicationsDL is vital in locking short-term performance while maintaining long-term performance opportunities through EP and ER to promote digital transformation. Accordingly, it induced banks to adopt new technology for value creation and fortifying competitive advantage.Originality/valueThis study provided a theory about how DL links the firm's decision-making process by promoting multiple patterns of action in achieving technical and evolutionary fitness. It highlighted the DL as a resource conceptualization that promotes resource development through EP and ER as microfoundation of dynamic capabilities during the tension of institutionalization and digital transformation.

Naturalistic Moral Realism and Evolutionary Biology

Perhaps the most familiar understanding of “naturalism” derives from Quine, understanding it as a continuity of empirical theories of the world as described through the scientific method. So, it might be surprising that one of the most important naturalistic moral realists, Philippa Foot, rejects standard evolutionary biology in her justly lauded Natural Goodness. One of her main reasons for this is the true claim that humans can flourish (eudaimonia) without reproducing, which she claims cannot be squared with evolutionary theory and biology more generally. The present argument concludes that Foot was wrong to reject evolutionary theory as the empirical foundation of naturalized eudaimonist moral realism. This is based on contemporary discussion of biological functions and evolutionary fitness, from which a definition of “eudaimonia” is constructed. This gives eudaimonist moral realism an empirically respectable foundation.

The Mediating Role of Boredom and Mind Wandering in the Relationship Between Evolutionary Fitness and Tendency to Substance Use Among University Students

Background: Substance abuse promotes a sense of self-perceived evolutionary ability by stimulating the cortico-mesolimbic in the brain. Although the relationship between substance use and evolutionary fitness has been demonstrated, the role of mediating variables that may contribute to the relationship between self-perceived evolutionary fitness and substance use is not clear yet. Objectives: The present study aimed to examine the relationship between self-perceived evolutionary fitness and the tendency to substance use and the mediating role of boredom and mind wandering in this relationship. Patients and Methods: This correlational study was performed using structural equation modeling (SEM). The statistical population comprised of all students at state-run universities of medical sciences in Tehran. A sample of 200 students from Iran University of Medical Sciences was selected via convenience sampling. Results: A significant negative correlation was found between evolutionary fitness and addiction potential (r = -0.75). The proposed model showed the direct effect factor of evolutionary fitness on addiction potential (β = -0.50, t = 7.90), boredom (β = -0.71, t = -14.12), and mind wandering (β = -0.46, t = -7.28). Moreover, the direct effect factor of boredom (β = 0.37, t = 5.94) and mind wandering (β = -0.02, t = -0.47) for addiction potential was established. Conclusions: Poor evolutionary fitness starts mind wandering about fitness-related issues. Eventually, this wandering leads to the unpleasant sense of boredom. Taking drugs artificially and temporarily increases evolutionary fitness and reduces one’s sense of boredom.

Differential impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germline

Telomerase extends chromosome ends in somatic and germline stem cells to ensure continued proliferation. Mutations in genes critical for telomerase function result in telomeropathies such as dyskeratosis congenita, frequently resulting in spontaneous bone marrow failure. A dyskeratosis congenita mutation in TPP1 (K170∆) that specifically compromises telomerase recruitment to telomeres is a valuable tool to evaluate telomerase-dependent telomere length maintenance in mice. We used CRISPR-Cas9 to generate a mouse knocked in for the equivalent of the TPP1 K170∆ mutation (TPP1 K82∆) and investigated both its hematopoietic and germline compartments in unprecedented detail. TPP1 K82∆ caused progressive telomere erosion with increasing generation number but did not induce steady-state hematopoietic defects. Strikingly, K82∆ caused mouse infertility, consistent with gross morphological defects in the testis and sperm, the appearance of dysfunctional seminiferous tubules, and a decrease in germ cells. Intriguingly, both TPP1 K82∆ mice and previously characterized telomerase knockout mice show no spontaneous bone marrow failure but rather succumb to infertility at steady-state. We speculate that telomere length maintenance contributes differently to the evolutionary fitness of humans and mice.

Immune Privilege of Heart Valves

Immune privilege is an evolutionary adaptation that protects vital tissues with limited regenerative capacity from collateral damage by the immune response. Classical examples include the anterior chamber of the eye and the brain. More recently, the placenta, testes and articular cartilage were found to have similar immune privilege. What all of these tissues have in common is their vital function for evolutionary fitness and a limited regenerative capacity. Immune privilege is clinically relevant, because corneal transplantation and meniscal transplantation do not require immunosuppression. The heart valves also serve a vital function and have limited regenerative capacity after damage. Moreover, experimental and clinical evidence from heart valve transplantation suggests that the heart valves are spared from alloimmune injury. Here we review this evidence and propose the concept of heart valves as immune privileged sites. This concept has important clinical implications for heart valve transplantation.

Asymmetric peptidoglycan editing generates the curvature of predatory bacteria, optimizing invasion and replication within a spherical prey niche

The vibrioid predatory bacterium Bdellovibrio bacteriovorus secretes prey wall-modifying enzymes to invade and replicate within the periplasm of Gram-negative prey bacteria. Studying self-modification of predator wall peptidoglycan during predation, we discover that Bd1075 generates self-wall curvature by exerting LD-carboxypeptidase activity in the vibrioid B. bacteriovorus strain HD100 as it grows inside spherical prey. Bd1075 localizes to the outer curved face of B. bacteriovorus, in contrast to most known shape-determinants. Asymmetric protein localization is determined by the novel function of a nuclear transport factor 2-like (NTF2) domain at the protein C-terminus. The solved structure of Bd1075 is monomeric, with key differences to other LD-carboxypeptidases. Rod-shaped Δbd1075 mutants invade prey more slowly than curved wild-type predators, and stretch and deform the invaded prey cell from within. Vibrioid morphology increases the evolutionary fitness of wild predatory bacteria, facilitating efficient prey invasion and intracellular growth of curved predators inside a spherical prey niche.

Ecological traps: evidence of a fitness cost in a cavity-nesting bird

Habitat quality has direct effects on the evolutionary fitness of breeding organisms, which is why it is believed that animals tend to have an evolved preference for the best possible habitats. However, some animals may mistakenly choose to reproduce in habitats that decrease their fitness, resulting in ‘ecological traps’. In this study, we tested whether great tits (Parus major) attracted to areas affected by outbreaks of the great web-spinning sawfly (Acantholyda posticalis) had fitness detriments characteristic of ecological traps. Sawfly larvae consume pine needles, which decreases resource availability for birds co-habiting the forest. Using artificial nesting sites, we found that great tits inhabiting areas of sawfly outbreaks had similar clutch sizes as tits breeding in healthy forest patches; however, the fledgling number was significantly lower, and fledgling condition was worse in the damaged forests. While moth larvae are the most important food for bird nestlings, the forest patches damaged by sawflies had lower larval biomass. Although most ecological traps occur in environments altered by humans, this study shows that pest insects can lower habitat quality, forming ecological traps. Our results indicate that attracting cavity-nesting birds should be done with caution because it may negatively impact birds’ nutritional status and reproductive fitness.