spontaneously hypertensive
Recently Published Documents


TOTAL DOCUMENTS

13285
(FIVE YEARS 871)

H-INDEX

123
(FIVE YEARS 10)

2022 ◽  
Vol 146 ◽  
pp. 112433
Author(s):  
Hye Yoom Kim ◽  
You Mee Ahn ◽  
Se Won Na ◽  
Youn Jae Jang ◽  
Dae Gill Kang ◽  
...  

Nutrients ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 328
Author(s):  
Patrícia Dias ◽  
Jana Pourová ◽  
Marie Vopršalová ◽  
Iveta Nejmanová ◽  
Přemysl Mladěnka

Regular intake of polyphenol-rich food has been associated with a wide variety of beneficial health effects, including the prevention of cardiovascular diseases. However, the parent flavonoids have mostly low bioavailability and, hence, their metabolites have been hypothesized to be bioactive. One of these metabolites, 3-hydroxyphenylacetic acid (3-HPAA), formed by the gut microbiota, was previously reported to exert vasorelaxant effects ex vivo. The aim of this study was to shed more light on this effect in vivo, and to elucidate the mechanism of action. 3-HPAA gave rise to a dose-dependent decrease in arterial blood pressure when administered i.v. both as a bolus and infusion to spontaneously hypertensive rats. In contrast, no significant changes in heart rate were observed. In ex vivo experiments, where porcine hearts from a slaughterhouse were used to decrease the need for laboratory animals, 3-HPAA relaxed precontracted porcine coronary artery segments via a mechanism partially dependent on endothelium integrity. This relaxation was significantly impaired after endothelial nitric oxide synthase inhibition. In contrast, the blockade of SKCa or IKCa channels, or muscarinic receptors, did not affect 3-HPAA relaxation. Similarly, no effects of 3-HPAA on cyclooxygenase nor L-type calcium channels were observed. Thus, 3-HPAA decreases blood pressure in vivo via vessel relaxation, and this mechanism might be based on the release of nitric oxide by the endothelial layer.


2022 ◽  
Vol 88 ◽  
pp. 104868
Author(s):  
Natália T.M. Calzerra ◽  
Mayara P. Melo ◽  
Pablo F. Santos ◽  
Kívia S. Assis ◽  
Priscilla M.P. Maciel ◽  
...  

2022 ◽  
Author(s):  
Sijia Wu ◽  
Wenzhu Zhao ◽  
Zhipeng Yu ◽  
Jingbo Liu

Tripeptide NCW identified in our previous study displayed strong ACE inhibitory activity, whether it has the antihypertensive effect in vivo remains unknown. Thus, in this paper, we aimed to investigate...


2022 ◽  
pp. 113017
Author(s):  
Ying Liu ◽  
Zhao-Jie Dong ◽  
Jia-Wei Song ◽  
Li-Rong Liang ◽  
Lan-Lan Sun ◽  
...  

Biologics ◽  
2021 ◽  
Vol 2 (1) ◽  
pp. 1-14
Author(s):  
Fatah B. Ahtesh ◽  
Lily Stojanovska ◽  
Vijay Mishra ◽  
Osaana Donkor ◽  
Jack Feehan ◽  
...  

Bioactive peptides are generated during milk fermentation or enzymatic hydrolysis. Lactobacillus (L) helveticus is commonly used to produce some types of fermented milk products. Fermented milk derived bioactive peptides are known to be beneficial in human health. Anti-hypertensive peptides play a dual role in the regulation of hypertension through the production of the vasoconstrictor angiotensin II and its inactivation of the vasodilator bradykinin. MALDI MS/MS, nano-LC/MS/MS and RP-HPLC were used to isolate peptides showing angiotensin converting enzyme inhibition (ACE-I) from 12% fermented skim milk using a combination of L. helveticus and Flavourzyme®. The fermentation procedure facilitated the identification of 133 anti-hypertensive peptides and 75% short chain amino acids, and the three with the highest ACE-I activity reduced blood pressure in a rat model of hypertension. The freeze- dried extract was supplemented in rodent chow. In this study 14-week-old male spontaneously hypertensive rats were fed for 10 weeks with the identified peptides added to chow and compared to controls supplemented with skim milk powder. Blood pressure (BP) decreased significantly (p < 0.05) from 6 to 10 weeks of FS groups (120/65 mmHg) compared with the NFS control groups, where the BP increased significantly (220/150 mmHg) (p < 0.05). The F6 fraction provided bioactive peptides with stronger antihypertensive properties than other fractions. Skim milk fermented by L. helveticus and Flavourzyme® generates several bioactive peptides which have a blood pressure lowering effect in hypertensive disease.


Biomedicines ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 38
Author(s):  
Andrea Berenyiova ◽  
Iveta Bernatova ◽  
Anna Zemancikova ◽  
Magdalena Drobna ◽  
Martina Cebova ◽  
...  

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infects host cells through angiotensin-converting enzyme 2 (ACE2). Concurrently, the product of ACE2 action, angiotensin 1–7 (Ang 1–7), binds to Mas receptors within the cardiovascular system and provides protective effects. Therefore, it is crucial to reveal the role of ACE2 inhibition, especially within pre-existing cardiovascular pathologies. In our study, we imitated the action of SARS-CoV-2 in organisms using the low dose of the ACE2 inhibitor MLN-4760 with the aim of investigating to what degree ACE2 inhibition is detrimental to the cardiovascular system of spontaneously hypertensive rats (SHRs), which represent a model of human essential hypertension. Our study revealed the complex action of MLN-4760 in SHRs. On the one hand, we found that MLN-4760 had 1) (pro)obesogenic effects that negatively correlated with alternative renin-angiotensin system activity and Ang 1–7 in plasma, 2) negative effects on ACE1 inhibitor (captopril) action, 3) detrimental effects on the small arteries function and 4) anti-angiogenic effect in the model of chick chorioallantoic membrane. On the other hand, MLN-4760 induced compensatory mechanisms involving strengthened Mas receptor-, nitric oxide- and hydrogen sulfide-mediated signal transduction in the aorta, which was associated with unchanged blood pressure, suggesting beneficial action of MLN-4760 when administered at a low dose.


Sign in / Sign up

Export Citation Format

Share Document