Mycobacterium marinum skin infection successfully treated with levofloxacin

1997 ◽  
Vol 133 (8) ◽  
pp. 947-949 ◽  
Author(s):  
S. Iijima
2003 ◽  
Vol 185 (5) ◽  
pp. 1745-1748 ◽  
Author(s):  
Jan Rybniker ◽  
Martina Wolke ◽  
Christiane Haefs ◽  
Georg Plum

ABSTRACT Mycobacterium marinum is a close relative of the obligate human pathogen Mycobacterium tuberculosis. As with M. tuberculosis, M. marinum causes intracellular infection of poikilothermic vertebrates and skin infection in humans. It is considered a valid model organism for the study of intracellular pathogenesis of mycobacteria. Low transformation efficiencies for this species have precluded approaches using mutant libraries in pathogenesis studies. We have adapted the conditionally replicating mycobacteriophage phAE94, originally developed as a transposon mutagenesis tool for M. tuberculosis, to meet the specific requirements of M. marinum. Conditions permissive for phage replication in M. tuberculosis facilitated highly efficient transposon delivery in M. marinum. Using this technique we succeeded in generating a representative mutant library of this species, and we conclude that TM4-derived mycobacteriophages are temperature-independent suicide vectors for M. marinum.


2017 ◽  
pp. 325-358
Author(s):  
Domenico Bonamonte ◽  
Angela Filoni ◽  
Michelangelo Vestita ◽  
Gianni Angelini

2015 ◽  
Vol 37 (2) ◽  
pp. 140-143
Author(s):  
Ahmed Anwar Aljowder ◽  
Azad Kareem Kassim ◽  
Mazen Raees

BMJ ◽  
1971 ◽  
Vol 2 (5760) ◽  
pp. 505-506 ◽  
Author(s):  
G I Barrow ◽  
M Hewitt

2018 ◽  
Vol 16 (5) ◽  
pp. 614-616 ◽  
Author(s):  
Sibylle Schliemann ◽  
Franziska Rässler ◽  
Jörg Tittelbach ◽  
Katharina Kranzer ◽  
Christine Zollmann ◽  
...  

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