scholarly journals Effect of Vericiguat, a Soluble Guanylate Cyclase Stimulator, on Natriuretic Peptide Levels in Patients With Worsening Chronic Heart Failure and Reduced Ejection Fraction

JAMA ◽  
2015 ◽  
Vol 314 (21) ◽  
pp. 2251 ◽  
Author(s):  
Mihai Gheorghiade ◽  
Stephen J. Greene ◽  
Javed Butler ◽  
Gerasimos Filippatos ◽  
Carolyn S. P. Lam ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Ejection Fraction ◽  
Natriuretic Peptide ◽  
Guanylate Cyclase ◽  
Soluble Guanylate Cyclase ◽  
Reduced Ejection Fraction ◽  
Soluble Guanylate Cyclase Stimulator

scholarly journals Discovery of the Soluble Guanylate Cyclase Stimulator Vericiguat (BAY 1021189) for the Treatment of Chronic Heart Failure

2017 ◽  
Vol 60 (12) ◽  
pp. 5146-5161 ◽  
Author(s):  
Markus Follmann ◽  
Jens Ackerstaff ◽  
Gorden Redlich ◽  
Frank Wunder ◽  
Dieter Lang ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Guanylate Cyclase ◽  
Soluble Guanylate Cyclase ◽  
Soluble Guanylate Cyclase Stimulator

scholarly journals Natriuretic Peptide Response and Outcomes in Chronic Heart Failure With Reduced Ejection Fraction

2019 ◽  
Vol 74 (9) ◽  
pp. 1205-1217 ◽  
Author(s):  
James L. Januzzi ◽  
Tariq Ahmad ◽  
Hillary Mulder ◽  
Adrian Coles ◽  
Kevin J. Anstrom ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Ejection Fraction ◽  
Natriuretic Peptide ◽  
Reduced Ejection Fraction

scholarly journals Evolution of B-type natriuretic peptide and N-terminal pro-brain natriuretic peptide during acute decompensated heart failure in a chronic heart failure patient with reduced ejection fraction treated with Sacubitril/Valsartan: a case report

2019 ◽  
Vol 3 (3) ◽  
Author(s):  
Ambre Tiepolo ◽  
Hélène Nougué ◽  
Charles Damoisel ◽  
Jean-Marie Launay ◽  
Nicolas Vodovar ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Ejection Fraction ◽  
Natriuretic Peptide ◽  
Acute Decompensated Heart Failure ◽  
Decompensated Heart Failure ◽  
Chronic Heart Failure Patient ◽  
Reduced Ejection Fraction ◽  
Case Summary ◽  
Acute Decompensation

Abstract Background B-type natriuretic peptide (BNP) and the N-terminal proBNP (NT-proBNP) exhibit different evolution in chronic heart failure patients with reduced ejection fraction treated with Sacubitril/Valsartan; BNP increasing or remaining stable, while NT-proBNP decreases. However, how this difference translates upon acute decompensation is unknown. Case summary Herein, we described in a 78-year-old woman with chronic heart failure with reduced ejection fraction treated with Sacubitril/Valsartan who had acute decompensated heart failure (ADHF). BNP and NT-proBNP were markedly high during ADHF and showed parallel return to baseline level after clinical improvement. Discussion BNP and NT-proBNP retained similar value for the diagnosis of ADHF in patient treated with Sacubitril/Valsartan. These findings strongly suggest that either BNP or NT-proBNP can be used indifferently in this context, while their relative use is debated in chronic heart failure.

Is natriuretic peptide lowering strategy superior to symptomatically based management of chronic heart failure with reduced ejection fraction?

2020 ◽  
Vol 79 ◽  
pp. 145-146
Author(s):  
Samarthkumar Thakkar ◽  
Rajkumar Doshi ◽  
Mariam Shariff ◽  
Igor Pedreira Vaz ◽  
Devina Adalja ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Ejection Fraction ◽  
Natriuretic Peptide ◽  
Reduced Ejection Fraction
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