The key steps for this synthetic approach are the preparation of o-spirodienone lactone 15, its reaction with methylvinyl ketone which gave 16 and 17, and the conversion of 16 and 17 into compound 19 by base. Finally ozonolysis of 26 followed by internal condensation gave compound 28.
Ring-closing enyne metathesis reaction has emerged as an elegant tool in organic synthesis for the creation of molecular complexity and used to prepare diverse heterocycles. In this mini review, I discuss that various linearly and angularly architecture heterocyclic compounds may be prepared using RCEM as key steps.