Researchers develop drug delivery system to slow and control tumors

Cancer ◽  
2016 ◽  
Vol 122 (24) ◽  
pp. 3751-3751 ◽  
Author(s):  
Carrie Printz
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
And Control

scholarly journals Pharmacodynamics and Pharmacokinetics Evaluation of Ranitidine Microemulsion on Experimental Animals

2014 ◽  
Vol 2014 ◽  
pp. 1-6
Author(s):  
Sajal Kumar Jha ◽  
Roopa Karki ◽  
Venkatesh Dinnekere Puttegowda ◽  
Amitava Ghosh
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Intestinal Permeability ◽  
Delivery System ◽  
Oral Delivery ◽  
Tween 80 ◽  
Standard Drug ◽  
Alternative Drug ◽  
And Control ◽  
Antiulcer Therapy

Ranitidine microemulsion was investigated for its pharmacodynamic and pharmacokinetic evaluation to find out the suitability of microemulsion as a potential drug delivery system in the treatment of ulcer. The bioavailability of ranitidine after oral administration is about 50% and is absorbed via the small intestine; this may be due to low intestinal permeability. Hence the aim of present investigation was to maximize the therapeutic efficacy of ranitidine by developing microemulsion to increase the intestinal permeability as well as bioavailability. A ground nut oil based microemulsion formulation with Tween-80 as surfactant and PEG-400 as cosurfactant was developed for oral delivery of ranitidine and characterized for physicochemical parameters. In pharmacodynamic studies, significant (P<0.05) variation in parameters estimated was found between the treated and control groups. Ranitidine microemulsion exhibited higher absorption and Cmax (863.20 ng·h/mL) than the standard (442.20 ng/mL). It was found that AUC0–24 hr obtained from the optimized ranitidine test formulation (5426.5 ng·h/mL) was significantly higher than the standard ranitidine (3920.4 ng·h/mL). The bioavailability of optimized formulation was about 1.4-fold higher than that of standard drug. This enhanced bioavailability of ranitidine microemulsion may be used as an effective and alternative drug delivery system for the antiulcer therapy.

The Physiology of the Liposome

Physiology ◽  
1989 ◽  
Vol 4 (4) ◽  
pp. 146-151 ◽  
Author(s):  
G Gregoriadis
Keyword(s):  
Drug Delivery ◽  
Clinical Trials ◽  
Drug Delivery System ◽  
Delivery System ◽  
Wide Spectrum ◽  
Experimental Animals ◽  
And Control

Understanding of the behavior and control of liposomes in vivo has led to their successful use as a drug delivery system in the treatment or prevention of a wide spectrum of diseases in experimental animals and, more recently, in clinical trials.

Ultrasonic Measurement and Control of Microrobotic Drug Delivery System

1992 ◽  
Vol 4 (3) ◽  
pp. 218-222
Author(s):  
Ken Ishihara ◽  
◽  
Toshiyuki Furukawa
Keyword(s):  
Drug Delivery ◽  
Blood Flow ◽  
Drug Delivery System ◽  
Delivery System ◽  
Imaging System ◽  
Drug Carriers ◽  
Ultrasonic Measurement ◽  
Resonant Ultrasound ◽  
And Control ◽  
Measurement And Control

We attempt a microrobotic drug delivery system (DDS) in which drug carriers of air-filled microcapsules are recognized with echography and are controlled using resonant ultrasound. We have confirmed the physical possibility of resonance design for drug carriers depending on the shell structure of the microcapsule. In addition, we have developed a novel echographic imaging system to locate microrobots precisely. Path lines of microrobots in blood flow could be clearly visualized.

scholarly journals Niosomes as Nano-carrier Based Targeted Drug Delivery System

2021 ◽  
Vol 11 (4-S) ◽  
pp. 166-170
Author(s):  
Chanchal Joy ◽  
Smitha K. Nair ◽  
K Krishna Kumar ◽  
B Dineshkumar
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Control Release ◽  
Cell Tissue ◽  
Potential Applications ◽  
Targeted Drug ◽  
And Control ◽  
Targeted Drug Delivery System

Niosomes are considered as novel nano-carrier in the drug delivery systems. These are much more stable than other nano-carriers like liposomes and nanoparticles. It is an example for targeted and control release of medication. The drug is entrapped into lipid core so that it prevents the drug from leaching. Here the drug will be targeted only to the desired cell/tissue and not to the non-targeted cells. By giving this formulation we can thereby reduce the dose of the drug and toxicity. This review article mainly emphasizes on the potential applications of niosomes in targeted drug delivery system. Keywords: niosomes, nanocarriers, targeted drug delivery.

Microfluidic Control of Microbeads and Ferrofluid in a Microtube

2013 ◽  
Author(s):  
Yuichi Shibata ◽  
Osamu Okamoto ◽  
Masahiro Kawaji
Keyword(s):  
Drug Delivery ◽  
Unsteady Flow ◽  
Permanent Magnet ◽  
Drug Delivery System ◽  
Delivery System ◽  
Flow Rate ◽  
Driving Force ◽  
And Behavior ◽  
And Control ◽  
Field Production

The field of microfluidics is developing with advances in MEMS, biotechnology and μ-TAS technologies. In various devices, controlling the flow rate of liquid or gas accurately at micro or nanoliter volume levels is required. By using a ferrofluid, the flow of a liquid or gas in a microchannel can be controlled by the driving power exerted on the ferrofluid. Also alginate microbeads can be applied to a study of transfer technology in a bioreactor and DDS (Drug Delivery System). In this field, production and control of microbeads are required. In the present study, an unsteady flow of a ferrofluid slug or microbead caused by the driving force exerted using a permanent magnet ring has been investigated in a 200μm circular microtube. The motion and behavior of the ferrofluid slug and microbead were observed. In addition, we examined the motion and stopping position.

NO-Responsive vesicles as a drug delivery system

2017 ◽  
Vol 53 (25) ◽  
pp. 3535-3538 ◽  
Author(s):  
Zhi-Heng Li ◽  
Zheng-Li Tan ◽  
Ai-Xiang Ding ◽  
Bing Gong ◽  
Zhong-Lin Lu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Aqueous Solution ◽  
Drug Delivery System ◽  
Delivery System ◽  
Living Cells ◽  
System P ◽  
Model Drug ◽  
And Control

A NO-response amphiphile was successfully formed into vesicles in aqueous solution, which could encapsulate and control the release of carboxyfluorescein (CF) as a model drug in vitro and in living cells.

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