Graft rejection by T cells not restricted by conventional major histocompatibility complex molecules

1993 ◽  
Vol 23 (10) ◽  
pp. 2725-2728 ◽  
Author(s):  
Andrée Dierich ◽  
Susan H. Chan ◽  
Christophe Benoist ◽  
Diane Mathis
Keyword(s):  
T Cells ◽  
Major Histocompatibility Complex ◽  
Graft Rejection ◽  
Major Histocompatibility ◽  
Complex Molecules ◽  
Histocompatibility Complex

scholarly journals The Role of Peptides in T Cell Alloreactivity Is Determined by Self–Major Histocompatibility Complex Molecules

2000 ◽  
Vol 191 (5) ◽  
pp. 805-812 ◽  
Author(s):  
Reinhard Obst ◽  
Nikolai Netuschil ◽  
Karsten Klopfer ◽  
Stefan Stevanović ◽  
Hans-Georg Rammensee
Keyword(s):  
T Cells ◽  
Major Histocompatibility Complex ◽  
T Cell ◽  
Target Cells ◽  
Major Histocompatibility ◽  
Complex Molecules ◽  
Mhc Molecules ◽  
Histocompatibility Complex ◽  
Alloreactive T Cells

By analyzing T cell responses against foreign major histocompatibility complex (MHC) molecules loaded with peptide libraries and defined self- and viral peptides, we demonstrate a profound influence of self-MHC molecules on the repertoire of alloreactive T cells: the closer the foreign MHC molecule is related to the T cell's MHC, the higher is the proportion of peptide-specific, alloreactive (“allorestricted”) T cells versus T cells recognizing the foreign MHC molecule without regard to the peptide in the groove. Thus, the peptide repertoire of alloreactive T cells must be influenced by self-MHC molecules during positive or negative thymic selection or peripheral survival, much like the repertoire of the self-restricted T cells. In consequence, allorestricted, peptide-specific T cells (that are of interest for clinical applications) are easier to obtain if T cells and target cells express related MHC molecules.

Extrathymic selection of TCR γδ+ T cells by class II major histocompatibility complex molecules

Cell ◽  
1990 ◽  
Vol 63 (2) ◽  
pp. 333-340 ◽  
Author(s):  
Leo Lefrancois ◽  
Rozenne LeCorre ◽  
Judy Mayo ◽  
Jeffrey A. Bluestone ◽  
Thomas Goodman
Keyword(s):  
T Cells ◽  
Major Histocompatibility Complex ◽  
Γδ T Cells ◽  
Class Ii ◽  
Major Histocompatibility ◽  
Complex Molecules ◽  
Histocompatibility Complex ◽  
Selection Of
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