scholarly journals White matter integrity and structural brain network topology in cerebral small vessel disease: The Hamburg city health study

2020 ◽  
Author(s):  
Benedikt M. Frey ◽  
Marvin Petersen ◽  
Eckhard Schlemm ◽  
Carola Mayer ◽  
Uta Hanning ◽  
...  
Keyword(s):  
White Matter ◽  
Network Topology ◽  
Small Vessel Disease ◽  
Brain Network ◽  
Cerebral Small Vessel Disease ◽  
White Matter Integrity ◽  
Health Study ◽  
Vessel Disease ◽  
Structural Brain Network ◽  
Structural Brain

scholarly journals Loss of white matter integrity is associated with gait disorders in cerebral small vessel disease

Brain ◽  
2010 ◽  
Vol 134 (1) ◽  
pp. 73-83 ◽  
Author(s):  
K. F. de Laat ◽  
A. M. Tuladhar ◽  
A. G. W. van Norden ◽  
D. G. Norris ◽  
M. P. Zwiers ◽  
...  
Keyword(s):  
White Matter ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Gait Disorders ◽  
White Matter Integrity ◽  
Small Vessel ◽  
Vessel Disease

Frontal white matter integrity and idiopathic dizziness in cerebral small vessel disease

2021 ◽  
Vol 429 ◽  
pp. 118504
Author(s):  
Richard Ibitoye ◽  
Patricia Castro ◽  
Josie Cooke ◽  
John Allum ◽  
Louisa Murdin ◽  
...  
Keyword(s):  
White Matter ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
White Matter Integrity ◽  
Small Vessel ◽  
Vessel Disease ◽  
Frontal White Matter

Frontal white matter integrity and idiopathic dizziness in cerebral small vessel disease

2021 ◽  
Vol 429 ◽  
pp. 117723
Author(s):  
Richard Ibitoye ◽  
Patricia Castro ◽  
Josie Cooke ◽  
John Allum ◽  
Louisa Murdin ◽  
...  
Keyword(s):  
White Matter ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
White Matter Integrity ◽  
Small Vessel ◽  
Vessel Disease ◽  
Frontal White Matter

scholarly journals The effect of the total small vessel disease burden on the structural brain network

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Xiaopei Xu ◽  
Kui Kai Lau ◽  
Yuen Kwun Wong ◽  
Henry K. F. Mak ◽  
Edward S. Hui
Keyword(s):  
Disease Burden ◽  
Small Vessel Disease ◽  
Brain Network ◽  
Small Vessel ◽  
Vessel Disease ◽  
Structural Brain Network ◽  
Structural Brain

White Matter Integrity and Depressive Symptoms in Cerebral Small Vessel Disease: The RUN DMC Study

2015 ◽  
Vol 23 (5) ◽  
pp. 525-535 ◽  
Author(s):  
Ingeborg W.M. van Uden ◽  
Anil M. Tuladhar ◽  
Karlijn F. de Laat ◽  
Anouk G.W. van Norden ◽  
David G. Norris ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
White Matter ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
White Matter Integrity ◽  
Small Vessel ◽  
Vessel Disease

scholarly journals Midlife Systemic Inflammation, Late-Life White Matter Integrity, and Cerebral Small Vessel Disease

Stroke ◽  
2017 ◽  
Vol 48 (12) ◽  
pp. 3196-3202 ◽  
Author(s):  
Keenan A. Walker ◽  
Melinda C. Power ◽  
Ron C. Hoogeveen ◽  
Aaron R. Folsom ◽  
Christie M. Ballantyne ◽  
...  
Keyword(s):  
White Matter ◽  
Systemic Inflammation ◽  
Small Vessel Disease ◽  
Late Life ◽  
Cerebral Small Vessel Disease ◽  
White Matter Integrity ◽  
Small Vessel ◽  
Vessel Disease

scholarly journals Venous disruption affects white matter integrity through increased interstitial fluid in cerebral small vessel disease

2020 ◽  
Vol 41 (1) ◽  
pp. 157-165
Author(s):  
Ruiting Zhang ◽  
Peiyu Huang ◽  
Yeerfan Jiaerken ◽  
Shuyue Wang ◽  
Hui Hong ◽  
...  
Keyword(s):  
White Matter ◽  
Interstitial Fluid ◽  
Diffusion Tensor ◽  
Small Vessel Disease ◽  
Free Water ◽  
Cerebral Small Vessel Disease ◽  
White Matter Integrity ◽  
Small Vessel ◽  
White Matter Damage ◽  
Vessel Disease

Deep medullary veins (DMVs) participate in the drainage of surrounding white matter. In cerebral small vessel disease (CSVD), disrupted DMVs were often observed together with damaged white matter, but the phenomenon lacked validation and explanation. We hypothesized that venous disruption might cause white matter damage through increased interstitial fluid resulting from hemodynamic alteration, and we designed a comprehensive multi-modality MRI study to testify our hypothesis. Susceptibility-weighted imaging was used to investigate the characteristics of DMVs and derive DMVs scores. Free water elimination diffusion tensor imaging model was used to analyze interstitial fluid fraction (fraction of free water, fFW) and white matter integrity (tissue fractional anisotropy, FAt). Totally, 104 CSVD patients were included. Total DMVs score was associated with FAt of DMVs drainage area. The effect of total DMVs score on FAt was mediated by fFW, after controlling for age, sex, hypertension, regional cerebral blood flow and lacune numbers. The relationships between DMVs score, fFW and FAt were also significant in most DMVs drainage subregions. Therefore, we discovered the DMVs disruption – increased interstitial fluid – white matter damage link in CSVD patients, which was independent of arterial perfusion variations.

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