scholarly journals Loss of white matter integrity is associated with gait disorders in cerebral small vessel disease

Brain ◽  
2010 ◽  
Vol 134 (1) ◽  
pp. 73-83 ◽  
Author(s):  
K. F. de Laat ◽  
A. M. Tuladhar ◽  
A. G. W. van Norden ◽  
D. G. Norris ◽  
M. P. Zwiers ◽  
...  
Keyword(s):  
White Matter ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Gait Disorders ◽  
White Matter Integrity ◽  
Small Vessel ◽  
Vessel Disease

Frontal white matter integrity and idiopathic dizziness in cerebral small vessel disease

2021 ◽  
Vol 429 ◽  
pp. 118504
Author(s):  
Richard Ibitoye ◽  
Patricia Castro ◽  
Josie Cooke ◽  
John Allum ◽  
Louisa Murdin ◽  
...  
Keyword(s):  
White Matter ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
White Matter Integrity ◽  
Small Vessel ◽  
Vessel Disease ◽  
Frontal White Matter

Frontal white matter integrity and idiopathic dizziness in cerebral small vessel disease

2021 ◽  
Vol 429 ◽  
pp. 117723
Author(s):  
Richard Ibitoye ◽  
Patricia Castro ◽  
Josie Cooke ◽  
John Allum ◽  
Louisa Murdin ◽  
...  
Keyword(s):  
White Matter ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
White Matter Integrity ◽  
Small Vessel ◽  
Vessel Disease ◽  
Frontal White Matter

White Matter Integrity and Depressive Symptoms in Cerebral Small Vessel Disease: The RUN DMC Study

2015 ◽  
Vol 23 (5) ◽  
pp. 525-535 ◽  
Author(s):  
Ingeborg W.M. van Uden ◽  
Anil M. Tuladhar ◽  
Karlijn F. de Laat ◽  
Anouk G.W. van Norden ◽  
David G. Norris ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
White Matter ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
White Matter Integrity ◽  
Small Vessel ◽  
Vessel Disease

scholarly journals Midlife Systemic Inflammation, Late-Life White Matter Integrity, and Cerebral Small Vessel Disease

Stroke ◽  
2017 ◽  
Vol 48 (12) ◽  
pp. 3196-3202 ◽  
Author(s):  
Keenan A. Walker ◽  
Melinda C. Power ◽  
Ron C. Hoogeveen ◽  
Aaron R. Folsom ◽  
Christie M. Ballantyne ◽  
...  
Keyword(s):  
White Matter ◽  
Systemic Inflammation ◽  
Small Vessel Disease ◽  
Late Life ◽  
Cerebral Small Vessel Disease ◽  
White Matter Integrity ◽  
Small Vessel ◽  
Vessel Disease

scholarly journals Venous disruption affects white matter integrity through increased interstitial fluid in cerebral small vessel disease

2020 ◽  
Vol 41 (1) ◽  
pp. 157-165
Author(s):  
Ruiting Zhang ◽  
Peiyu Huang ◽  
Yeerfan Jiaerken ◽  
Shuyue Wang ◽  
Hui Hong ◽  
...  
Keyword(s):  
White Matter ◽  
Interstitial Fluid ◽  
Diffusion Tensor ◽  
Small Vessel Disease ◽  
Free Water ◽  
Cerebral Small Vessel Disease ◽  
White Matter Integrity ◽  
Small Vessel ◽  
White Matter Damage ◽  
Vessel Disease

Deep medullary veins (DMVs) participate in the drainage of surrounding white matter. In cerebral small vessel disease (CSVD), disrupted DMVs were often observed together with damaged white matter, but the phenomenon lacked validation and explanation. We hypothesized that venous disruption might cause white matter damage through increased interstitial fluid resulting from hemodynamic alteration, and we designed a comprehensive multi-modality MRI study to testify our hypothesis. Susceptibility-weighted imaging was used to investigate the characteristics of DMVs and derive DMVs scores. Free water elimination diffusion tensor imaging model was used to analyze interstitial fluid fraction (fraction of free water, fFW) and white matter integrity (tissue fractional anisotropy, FAt). Totally, 104 CSVD patients were included. Total DMVs score was associated with FAt of DMVs drainage area. The effect of total DMVs score on FAt was mediated by fFW, after controlling for age, sex, hypertension, regional cerebral blood flow and lacune numbers. The relationships between DMVs score, fFW and FAt were also significant in most DMVs drainage subregions. Therefore, we discovered the DMVs disruption – increased interstitial fluid – white matter damage link in CSVD patients, which was independent of arterial perfusion variations.

Higher Cerebral Small Vessel Disease Burden in Patients with White Matter Recent Small Subcortical Infarcts

2021 ◽  
Vol 30 (7) ◽  
pp. 105824
Author(s):  
Salvatore Rudilosso ◽  
Luis Mena ◽  
Diana Esteller ◽  
Marta Olivera ◽  
Juan José Mengual ◽  
...  
Keyword(s):  
White Matter ◽  
Disease Burden ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Vessel Disease

scholarly journals Cognitive heterogeneity among community-dwelling older adults with Cerebral Small Vessel Disease

2018 ◽  
Author(s):  
Ayan Dey ◽  
Vessela Stamenova ◽  
Agnes Bacopulos ◽  
Nivethika Jeyakumar ◽  
Gary R. Turner ◽  
...  
Keyword(s):  
White Matter ◽  
Subjective Experience ◽  
Small Vessel Disease ◽  
Neuropsychological Testing ◽  
Cerebral Small Vessel Disease ◽  
Community Dwelling ◽  
Small Vessel ◽  
Vessel Disease ◽  
Age Related ◽  
Subjective Complaints

Some degree of ischemic injury to white matter tracts occurs naturally with age and is visible on magnetic resonance imaging as focal or confluent white matter hyperintensities (WMHs). Its relationship to cognition, however, remains unclear. To explore this, community-dwelling adults between the ages 55-80 years old completed structural imaging, neuropsychological testing, and questionnaires to provide objective measures and subjective experience of executive functioning. Volumetric lesion burden derived from structural MRI identified those with significant WMH burden (~10 cubic cm). Half of those recruited met this criterion and were designated as the cerebral small vessel disease (CSVD) group. Subjective complaints but not objective test scores differentiated adults with and without CSVD. Hierarchical clustering revealed two CSVD subgroups that differentiated those with impaired versus preserved executive function relative to controls. Overall these results provide some explanation for behavioural heterogeneity often observed in studies of age-related white matter changes. They also support the use of questionnaires to assess subjective complaints that may be able to detect subtle effects of pathology not evident on standardized cognitive scores.

Abstract P369: Cerebral Small Vessel Disease and Enlarged Cardiac Ventricles

Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Kayla Navarro ◽  
Ka-ho Wong ◽  
Majd M Ibrahim ◽  
Adam H De Havenon ◽  
Eric Goldstein
Keyword(s):  
White Matter ◽  
Ejection Fraction ◽  
Right Ventricular ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Right Atrial ◽  
Ventricular Ejection Fraction ◽  
Vessel Disease ◽  
Atrial Area

Introduction: White matter hyperintensities (WMH) are a radiographic marker for cerebral small vessel disease (CSVD). Conditions altering cerebral venous outflow such as elevated central venous pressure and right atrial pressure in individuals with cardiac valvular disease have been implicated in the development of WMH. Hypothesis: We hypothesize that increased right-heart chamber size in individuals without significant cardiac valvular disease is associated with worse WMH. Methods: A retrospective chart review of adults with a brain MRI and a 2-dimensional transthoracic echocardiogram (TTE) was performed. Worst burden of WMH by way of Fazekas score, either periventricular or deep white matter, served as the primary outcome. Statistical analysis was performed using a multivariate ordinal logistic regression model. Results: A total of 132 individuals were included. Right atrial area (OR 0.93, 95% CI 0.87 to 1.00, p = 0.0041), right ventricular internal diameter (OR 0.48, 95%CI 0.27 to 0.83, p = 0.008) and left atrial area (OR 0.93, 95%CI 0.88 to 0.98, p = 0.007) was identified as being significant. Cardiac functional markers were not significant, including tricuspid annular plane systolic excursion (OR 0.99, 95%CI 0.93 to 1.05, p = 0.670), right ventricular ejection fraction (OR 0.99, 95%CI 0.96 to 1.02, p = 0.670) and left ventricular ejection fraction (OR 0.99, 95%CI 0.96 to 1.02, p = 0.567). Analysis of isolated DWM or PVWM Fazekas scores did not find significant predictors in relation to cardiac structure or function. Conclusions: Through non-invasive cardiac imaging, we identified that cardiac structural abnormalities as opposed to functional abnormalities were associated with worse WMH. Mechanistically this may result from altered intracerebral arteriovenous coupling or a shared pathophysiologic pathway between WMH and coronary microvascular disease.

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