scholarly journals Poorly differentiated adenocarcinoma and mucinous carcinoma of the colon and rectum show higher rates of loss of heterozygosity and loss of E-cadherin expression due to methylation of promoter region

2002 ◽  
Vol 102 (3) ◽  
pp. 225-229 ◽  
Author(s):  
Takamitsu Kanazawa ◽  
Toshiaki Watanabe ◽  
Shinsuke Kazama ◽  
Toshihiro Tada ◽  
Shinichiro Koketsu ◽  
...  
Keyword(s):  
Loss Of Heterozygosity ◽  
Promoter Region ◽  
Mucinous Carcinoma ◽  
Poorly Differentiated Adenocarcinoma ◽  
Carcinoma Of The Colon ◽  
Colon And Rectum ◽  
Poorly Differentiated ◽  
E Cadherin

scholarly journals CLINICOPATHOLOGICAL STUDY OF POORLY DIFFERENTIATED ADENOCARCINOMA AND MUCINOUS CARCINOMA OF THE COLON

1993 ◽  
Vol 43 (2) ◽  
pp. 147-152
Author(s):  
TOMIO SAWADA ◽  
SUSUMU OHWADA ◽  
IZUMI TAKEYOSHI ◽  
SEIJI NAKAMURA ◽  
YUKIO MIYAMOTO ◽  
...  
Keyword(s):  
Mucinous Carcinoma ◽  
Poorly Differentiated Adenocarcinoma ◽  
Carcinoma Of The Colon ◽  
Clinicopathological Study ◽  
Poorly Differentiated

CLINICAL AND PATHOLOGICAL FEATURES OF MUCINOUS CARCINOMA OF THE COLON AND RECTUM

1987 ◽  
Vol 48 (5) ◽  
pp. 609-614
Author(s):  
Masahiro OKUNO ◽  
Teruyuki IKEHARA ◽  
Masayoshi NAGAYAMA ◽  
Yasuyuki KATO ◽  
Saburo YUI ◽  
...  
Keyword(s):  
Mucinous Carcinoma ◽  
Pathological Features ◽  
Carcinoma Of The Colon ◽  
Colon And Rectum ◽  
Clinical And Pathological Features

scholarly journals CLINICAL AND PATHOLOGICAL ANALYSIS OF MUCINOUS CARCINOMA OF THE COLON AND RECTUM

1992 ◽  
Vol 53 (10) ◽  
pp. 2347-2351
Author(s):  
Masaaki OKA ◽  
Tetsuji UCHIYAMA ◽  
Hiroshi OGURA ◽  
Takashi SUZUKI
Keyword(s):  
Mucinous Carcinoma ◽  
Carcinoma Of The Colon ◽  
Pathological Analysis ◽  
Colon And Rectum

scholarly journals Microsatellite Instability in Medullary Carcinoma of the Colon

Rare Tumors ◽  
2016 ◽  
Vol 9 (1) ◽  
pp. 23-25 ◽  
Author(s):  
Mario Martinotti ◽  
Fernando Cirillo ◽  
Marco Ungari ◽  
Giulia Tanzi ◽  
Giovanni Rolando ◽  
...  
Keyword(s):  
Microsatellite Instability ◽  
Medullary Carcinoma ◽  
Good Health ◽  
Caucasian Woman ◽  
Poorly Differentiated Adenocarcinoma ◽  
Carcinoma Of The Colon ◽  
Stenotic Lesion ◽  
Dna Mismatch ◽  
Poorly Differentiated

Medullary carcinoma (MC) of the large intestine is a relatively new histological type of adenocarcinoma characterized by poor glandular differentiation and an intraepithelial lymphocytic infiltrate. MC can be associated to a defective mechanism for DNA mismatch repair, caused by the so-called microsatellite instability (MSI). We present the case of a 44 years old Caucasian woman, who referred to the Emergency Room with symptoms mimicking an acute appendicitis. Computed tomography and colonoscopy demonstrated an ulcerated and stenotic lesion of the caecum without signs of metastasis and peritoneal carcinosis. Patient underwent a laparoscopic right colectomy. The final pathologic findings provided the diagnosis of medullary carcinoma with MSI. Patient then underwent adjuvant chemotherapy according to the FOLFOX-4 protocol (association of 5-Fluorouracil, Leucovorin, and Oxaliplatin) for twelve cycles. At two-years follow-up, patient is disease free. MC in association with MSI is a non-frequent tumor of the colon characterized by a better prognosis compared to other types of poorly differentiated adenocarcinoma. In the observed case, 24 months after the surgical operation, the patient is in good health and there is no evidence of metastasis or relapse.

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