scholarly journals CLINICOPATHOLOGICAL FEATURES OF POORLY DIFFERENTIATED ADENOCARCINOMA OF THE COLON AND RECTUM

1992 ◽  
Vol 53 (2) ◽  
pp. 313-317
Author(s):  
Sengai TANAKA ◽  
Hiroo OSHITA ◽  
Daizo FUKATA
1992 ◽  
Vol 25 (7) ◽  
pp. 1984-1988 ◽  
Author(s):  
Eiji Miyahara ◽  
Koji Ikejiri ◽  
Soichirou Maekawa ◽  
Yasuhiro Yoshida ◽  
Shigeru Yakabe ◽  
...  

1993 ◽  
Vol 26 (4) ◽  
pp. 1013-1017 ◽  
Author(s):  
Wataru Fukushima ◽  
Koji Konishi ◽  
Hiroyuki Sahara ◽  
Hisashi Matsumoto ◽  
Naotake Kadoya ◽  
...  

ISRN Surgery ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-3 ◽  
Author(s):  
Serenella Civitelli ◽  
Barbara Civitelli ◽  
Jacopo Martellucci ◽  
Gabriello Tanzini

Cutaneous metastases from large bowel cancer are uncommon and are usually associated with organ involvement. Localization of lesions to the skin is mainly attributed to vascular and anatomical relationship, since most of them are seen in the abdominal wall or in a surgical scar. We report a 73-year-old woman in whom metastatic nodules from a poorly differentiated adenocarcinoma of the right colon developed throughout the skin (buttock, trunk, chest wall, arms, and neck) and remained the only sign of extranodal tumor spread until patient's death, seven months later. This unusual behaviour suggests that localization of neoplastic cells to the skin may be a site-specific process, determined by adhesion molecules and/or by growth factors found at that site.


2011 ◽  
Vol 58 (2) ◽  
pp. 41-46 ◽  
Author(s):  
TAKEFUMI YOSHIDA ◽  
YOSHITO AKAGI ◽  
TETSUSHI KINUGASA ◽  
ICHITARO SHIRATSUCHI ◽  
YASUHIKO RYU ◽  
...  

1995 ◽  
Vol 81 (4) ◽  
pp. 230-233 ◽  
Author(s):  
Tuncay Yılmazlar ◽  
Abdullah Zorluoğlu ◽  
Halil Özgüç ◽  
Nusret Korun ◽  
Hakan Duman ◽  
...  

The study was carried out to promote a greater awareness of the potential for colorectal cancer in young adults under 40 years of age. During the 8 years between 1986 and 1993, 237 patients with adenocarcinoma of the colon and rectum were operated at the Uludağ University Hospital. Of these 237 cases, 46 patients under 40 years old were reviewed retrospectively. They accounted for 19.4% of the total number of patients with carcinoma of the colon and rectum operated during the same period. Rectal bleeding was the most common presenting symptom. The mean duration of time from the onset of symptoms to diagnosis was 5.8 months. The rectosigmoid area was the most frequently involved site (80%). Seventy-six percent of the patients had Dukes’ stage C or D tumors. Forty-eight percent of the tumors were either poorly differentiated or mucinous. The cumulative survival rate at 5 years was 43.4%. Patients under 40 years old with carcinoma of the colon and rectum are usually symptomatic and have advanced disease at the time of presentation. Although colorectal cancer is usually a disease of older patients it is becoming more common in younger populations.


2021 ◽  
Author(s):  
Kai Song ◽  
Qi Yang ◽  
Yu Yan ◽  
Xiaoyan Yu ◽  
Kanlun Xu ◽  
...  

Abstract Background:The distribution of mucin phenotypes and its relationship with clinicopathological features in early differentiated gastric adenocarcinomas among the Chinese cohort is unknow. We aim to investigate the mucin phenotypes and analyze the relationship between mucin phenotypes and clinicopathological features, especially the biological behavior, in early differentiated gastric adenocarcinomas from endoscopic specimens in a Chinese cohort.Methods:Immunohistochemical staining of CD10, MUC2, MUC5AC, MUC6 was performed in 257 patients with early differentiated gastric adenocarcinomas. Tumor location, gross type, tumor size, histological type, depth of invasion, lymphovascular invasion, mucosal background and other clinicopathological parameters were evaluated. Analyzed the relationship between mucin phenotypes and clinicopathological features through chi-square test.ResultsThe incidence of ໿ gastric-, gastrointestinal-, intestinal- and null-phenotype was 21%, 56%, 20% and 3% respectively. The mucin phenotypes were related with histology classification (P༜0.05). The proportion of gastric-phenotype became greater during the transition from differentiated to undifferentiated (P༜0.05). Complete intestinal metaplasia in gastric- and intestinal-phenotype was higher than gastrointestinal-phenotype (P༜0.05). Those mixed with poorly differentiated adenocarcinoma were mainly of gastric-phenotype, which was significantly higher than that of purely differentiated tubular adenocarcinoma (P < 0.05), and the depth of infiltration of mixed type was deeper (P < 0.05). Neither recurrence nor metastasis were detected.ConclusionsThe mucin phenotype of early differentiated gastric adenocarcinoma is of clinical implication, and gastric-phenotype has aggressive biological behavior in early differentiated gastric cancers, especially in those mixed with poorly differentiated adenocarcinoma or papillary adenocarcinoma component.


2002 ◽  
Vol 35 (6) ◽  
pp. 678-681 ◽  
Author(s):  
Tetsuo Ishikawa ◽  
Ryoutarou Nakashima ◽  
Osamu Takahashi ◽  
Toshimitsu Matsusaka

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