scholarly journals Synthetic lethality in DNA repair network: A novel avenue in targeted cancer therapy and combination therapeutics

IUBMB Life ◽  
2017 ◽  
Vol 69 (12) ◽  
pp. 929-937 ◽  
Author(s):  
Sonali Bhattacharjee ◽  
Saikat Nandi
Keyword(s):  
Dna Repair ◽  
Cancer Therapy ◽  
Synthetic Lethality ◽  
Targeted Cancer Therapy

scholarly journals Targeting DNA Repair and Chromatin Crosstalk in Cancer Therapy

Cancers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 381
Author(s):  
Danielle P. Johnson ◽  
Mahesh B. Chandrasekharan ◽  
Marie Dutreix ◽  
Srividya Bhaskara
Keyword(s):  
Dna Repair ◽  
Cancer Therapy ◽  
Therapeutic Intervention ◽  
Synthetic Lethality ◽  
Checkpoint Proteins ◽  
Cellular Processes ◽  
Repair Pathways ◽  
Made In

Aberrant DNA repair pathways that underlie developmental diseases and cancers are potential targets for therapeutic intervention. Targeting DNA repair signal effectors, modulators and checkpoint proteins, and utilizing the synthetic lethality phenomena has led to seminal discoveries. Efforts to efficiently translate the basic findings to the clinic are currently underway. Chromatin modulation is an integral part of DNA repair cascades and an emerging field of investigation. Here, we discuss some of the key advancements made in DNA repair-based therapeutics and what is known regarding crosstalk between chromatin and repair pathways during various cellular processes, with an emphasis on cancer.

Targeted Cancer Therapy; Nanotechnology Approaches for Overcoming Drug Resistance

2015 ◽  
Vol 22 (11) ◽  
pp. 1335-1347 ◽  
Author(s):  
Yan Gao ◽  
Jacson Shen ◽  
Lara Milane ◽  
Francis Hornicek ◽  
Mansoor Amiji ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Cancer Therapy ◽  
Targeted Cancer Therapy

Biological Carrier Molecules of Radiopharmaceuticals for Molecular Cancer Imaging and Targeted Cancer Therapy

2014 ◽  
Vol 20 (32) ◽  
pp. 5218-5244 ◽  
Author(s):  
A. Aerts ◽  
N.R.E.N. Impens ◽  
M. Gijs ◽  
M. D'Huyvetter ◽  
H. Vanmarcke ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Cancer Imaging ◽  
Targeted Cancer Therapy

TEM8 Targeted Cancer Therapy

2011 ◽  
Vol 11 (10) ◽  
pp. 983-992 ◽  
Author(s):  
Arthur E. Frankel ◽  
Carol Carter ◽  
Shu-Ru Kuo ◽  
Jung-Hee Woo ◽  
Jeremy Mauldin ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Targeted Cancer Therapy

Novel Nanotechnology Approaches for Targeted Cancer Therapy

2014 ◽  
Vol 3 (2) ◽  
pp. 83-88 ◽  
Author(s):  
Maria Gazouli ◽  
Nikolitsa Nomikou ◽  
John F Callan ◽  
Efstathios P. Efstathopoulos
Keyword(s):  
Cancer Therapy ◽  
Targeted Cancer Therapy

Comparative radium-223 labeling with NOTA and DOTA-somatostatin derivatives for a potential use in targeted cancer therapy

2019 ◽  
Vol 72-73 ◽  
pp. S50-S51
Author(s):  
M. Riondato ◽  
S. Pastorino ◽  
V. Duce ◽  
E. Giovannini ◽  
A. Ciarmiello
Keyword(s):  
Cancer Therapy ◽  
Targeted Cancer Therapy ◽  
Radium 223 ◽  
Potential Use

Multicolor Two‐photon Nanosystem for Multiplexed Intracellular Imaging and Targeted Cancer Therapy

2021 ◽  
Author(s):  
Yong-Xiang Wu ◽  
Dailiang Zhang ◽  
Xiaoxiao Hu ◽  
Ruizi Peng ◽  
Junbin Li ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Targeted Cancer Therapy ◽  
Intracellular Imaging ◽  
Two Photon
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