The relationship of expression of statin, the nuclear protein of nonproliferating cells, to the differentiation and cell cycle of astroglia in cultures and in situ

1990 ◽  
Vol 26 (1) ◽  
pp. 1-15 ◽  
Author(s):  
S. Fedoroff ◽  
I. Ahmed ◽  
E. Wang
Keyword(s):  
Cell Cycle ◽  
Nuclear Protein ◽  
Relationship Of ◽  
The Relationship

Open innovation practices adopted by private stakeholders: perspectives for living labs

Info ◽  
2015 ◽  
Vol 17 (4) ◽  
pp. 67-80 ◽  
Author(s):  
Dominic Lapointe ◽  
David Guimont
Keyword(s):  
Open Innovation ◽  
Research Literature ◽  
Extensive Literature ◽  
Content Type ◽  
Living Lab ◽  
Living Labs ◽  
Innovation Practices ◽  
Relationship Of ◽  
The Relationship

Purpose – This paper aims to explore the role of private stakeholders in the living lab (LL) ecosystem and the relationship of private stakeholders to open innovation (OI) practices. There is extensive literature on private stakeholders and OI, but seldom mention is made on the specific question of how private stakeholders integrate OI in the context of a LL. Design/methodology/approach – The authors will analyze qualitatively how private businesses that have participated in a in situ open innovation evaluate and perceived their open innovation practices. Therefore, how they relate to open innovation. Then, the authors will identify a typology of the businesses in relation to OI. Findings – The research focused on the relationship of private stakeholders to OI in the context of in situ OI activities. The results obtained are consistent with literature on OI (Chesbrough, 2003). However, there are differences: if the elements mentioned by the respondents are described in literature, their representation of OI and its components allows us to affirm that this practice is not generalised and that it is often open to interpretation. That emphasises the importance of the role LLs can play as intermediaries to accompany private stakeholders in the OI process. Private stakeholders look for a guide to develop their OI know-how and find their way in the OI ecosystem. Originality/value – The value of this paper is to bridge the research on OI done with private organisation and the research on LLs. The research literature did not pay much attention to the representation of the private stakeholders in the OI ecosystem. This paper has provided the start to open up that field.

scholarly journals Mixed-Valence Cytoplasmic Iron Granules Are Linked to Anaerobic Respiration

2006 ◽  
Vol 73 (3) ◽  
pp. 993-996 ◽  
Author(s):  
S. Glasauer ◽  
S. Langley ◽  
M. Boyanov ◽  
B. Lai ◽  
K. Kemner ◽  
...  
Keyword(s):  
Ferrous Iron ◽  
Metal Particle ◽  
Ferric Iron ◽  
Solid Phase ◽  
Mixed Valence ◽  
Anaerobic Respiration ◽  
In Situ Detection ◽  
Relationship Of ◽  
The Relationship

ABSTRACT Intracellular granules containing ferric and ferrous iron formed in Shewanella putrefaciens CN32 during dissimilatory reduction of solid-phase ferric iron. It is the first in situ detection at high resolution (150 nm) of a mixed-valence metal particle residing within a prokaryotic cell. The relationship of the internal particles to Fe(III) reduction may indicate a respiratory role.

scholarly journals EFFECT OF BLASTING ON THE STABILITY OF LINING DURING EXCAVATION OF NEW TUNNEL NEAR THE EXISTING TUNNEL

2021 ◽  
Vol 30 (1) ◽  
Author(s):  
Tuan Minh Tran ◽  
Quang Huy Nguyen
Keyword(s):  
Field Data ◽  
Damage Zone ◽  
Field Tests ◽  
Surrounding Rock ◽  
In Situ Test ◽  
The Stability ◽  
Relationship Of ◽  
The Impact ◽  
The Relationship

In recent years, experimental and numerical researches on the effect of blasting pressure on the stability of existing tunnels was widely obtained. However, the effect of the blasting pressure during excavation a new tunnel or expansion old tunnels on an existing tunnel has disadvantages and still unclear. Some researches were carried out to study the relationship of the observed Peak Particle Velocity (PPV) on the lining areas along the existing tunnel direction, due to either the lack of in situ test data or the difficulty in conducting field tests, particularly for tunnels that are usually old and vulnerable after several decades of service. This paper introduces using numerical methods with the field data investigations on the effect of the blasting in a new tunnel on the surrounding rock mass and on the existing tunnel. The research results show that not only predicting the tunnel lining damage zone under the impact of blast loads but also determination peak maximum of explosion at the same time at the surface of tunnel working.

scholarly journals Abundant expression of transcription factor GATA-2 in proliferating but not in differentiated mast cells in tissues of mice: demonstration by in situ hybridization

Blood ◽  
1996 ◽  
Vol 87 (3) ◽  
pp. 993-998 ◽  
Author(s):  
T Jippo ◽  
H Mizuno ◽  
Z Xu ◽  
S Nomura ◽  
M Yamamoto ◽  
...  
Keyword(s):  
Mast Cell ◽  
In Situ Hybridization ◽  
Mast Cells ◽  
Differentiation Markers ◽  
Two Parameters ◽  
High Affinity Ige Receptor ◽  
Relationship Of ◽  
The Relationship ◽  
Receptor Beta

Although GATA-binding transcription factors (GATA-1 and GATA-2) are strongly expressed in cultured mast cells (CMCs), their expression in mast cells within tissues has not been reported. We examined the expression of GATA-1 and GATA-2 in skin tissues of mice using Northern blot analysis and in situ hybridization. mRNA for GATA-2 but not for GATA-1 was expressed in skin mast cells of WB-+/+ embryos between days 15 and 17 postcoitum (pc). The expression was downregulated on and after day 18 pc. Skin mast cells did not express GATA-2 after birth either. When the number of skin mast cells was compared with the number of GATA-2 mRNA-expressing cells, GATA-2 mRNA appeared to be expressed by mast cells only when the number was increasing. When the mRNA expression of high-affinity IgE receptor beta-subunit and mast cell carboxypeptidase A was used as differentiation markers, the expression of these mRNAs continued even after the downregulation of GATA-2 expression. To clarify the relationship of the proliferation and GATA-2 expression, proliferating CMCs derived from WBB6F1-+/+ mice were transplanted into the peritoneal cavity of mast cell-deficient WBB6F1- W/Wv mice. The CMCs stopped both the proliferation and GATA-2 expression after the transplantation, suggesting the association of these two parameters in mast cells within tissues of mice.

Scanning Studies of Cell Surfaces

1973 ◽  
Vol 31 ◽  
pp. 608-609
Author(s):  
Virginia Fonte ◽  
Nancy Weller ◽  
Keith R. Porter
Keyword(s):  
Cell Cycle ◽  
Structural Organization ◽  
Cell Surfaces ◽  
Detailed Characterization ◽  
A Cell ◽  
Relationship Of ◽  
The Relationship ◽  
Scanning Electron

The surfaces of a cell in its topography and anti-genicity expresses subtle variations in the effective genome, as well as the physiology and structural organization of the underlying cytoplasm. Understanding the relationship of these various factors to the surface depends in part on obtaining a detailed characterization of the topography of cells and how this topography changes with phases in the cell cycle, with transformation to malignancy and with the cell's response to such physiologically active agents as cyclic AMP.We have therefore explored the usefulness of the scanning electron microscope in investigations of the cell's topography. Cells grown under favourable in vitro conditions have been fixed in glutaraldehyde, dehydrated in acetone and dried by the critical point method of Anderson.

scholarly journals Simultaneous assessment of TGFB and cell cycle kinetics using IUdR/BrdU infusions in human neoplasms from plastic-embedded tissue.

1992 ◽  
Vol 40 (3) ◽  
pp. 427-430 ◽  
Author(s):  
M A Miller ◽  
S A Bokhari ◽  
K Qadir ◽  
A Raza
Keyword(s):  
Cell Cycle ◽  
Transforming Growth Factor ◽  
Nerve Fibers ◽  
S Phase ◽  
Cell Cycle Kinetics ◽  
Factor B ◽  
Immunohistochemical Technique ◽  
The Relationship ◽  
Simultaneous Assessment

We describe an immunohistochemical technique that makes use of two monoclonal antibodies (MAb), one to detect the transforming growth factor B (TGFB) and another that reacts with iodo- and bromodeoxyuridine. The purpose of this technique is to determine the relationship between TGFB expression and the S-phase cells in human tumors. Since both can be distinctly identified in situ from tissue embedded in plastic, in assessment of the geographic orientation of S-phase cells in relation to such factors as TGFB, contiguity to blood vessels, nerve fibers, and macrophages can also be achieved.

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