Fatty Acid and Water-Soluble Polymer-Based Controlled Release Drug Delivery System

2011 ◽  
Vol 100 (5) ◽  
pp. 1900-1912 ◽  
Author(s):  
Divyakant Desai ◽  
Sanjeev Kothari ◽  
Wei Chen ◽  
Jennifer Wang ◽  
Ming Huang ◽  
...  
2013 ◽  
Vol 651 ◽  
pp. 227-231
Author(s):  
Qiang Song Wang ◽  
Yuan Lu Cui ◽  
Tian Jiao Dong

The purpose of the study was to prepare and evaluation chitosin-coated alginate/gelatin microspheres for sustained-release drug delivery system in vitro. The microspheres were prepared with an emulsification technique, characterized by scanning electron microscopy (SEM), Fourier transform infrared spectrophotometry (FT-IR), differential scanning calorimetry (DSC). The average particle size of the chitosan-coated alginate/gelatin microspheres was uniform. The results of FT-IR and DSC showed that the microspheres were formed by intermolecular cross-linkages between chitosan and gelatin. The results also implied that the microsphere were a practicable dosage form to increase drug loading ratio for the poorly water-soluble drugs by encapsulated with chitosan. In vitro release of the microsphere indicated that it had a satisfactory sustained-release behavior for the sustained-release drug delivery system.


2012 ◽  
Vol 59 (3) ◽  
pp. 1578-1587 ◽  
Author(s):  
Pen-Li Huang ◽  
Po-Hung Kuo ◽  
Yu-Jie Huang ◽  
Hsin-Hung Liao ◽  
Yao-Joe Joseph Yang ◽  
...  

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