Development of a Human Antibody Tolerant Mouse Model to Assess the Immunogenicity Risk Due to Aggregated Biotherapeutics

2013 ◽  
Vol 102 (10) ◽  
pp. 3545-3555 ◽  
Author(s):  
Vivian Bi ◽  
Vibha Jawa ◽  
Marisa K. Joubert ◽  
Arunan Kaliyaperumal ◽  
Catherine Eakin ◽  
...  
Keyword(s):  
Mouse Model ◽  
Human Antibody ◽  
Tolerant Mouse

scholarly journals Long-Term Expression of Human Coagulation Factor VIII in a Tolerant Mouse Model Using the φC31 Integrase System

2012 ◽  
Vol 23 (4) ◽  
pp. 390-398 ◽  
Author(s):  
Christopher L. Chavez ◽  
Annahita Keravala ◽  
Jacqueline N. Chu ◽  
Alfonso P. Farruggio ◽  
Vanessa E. Cuéllar ◽  
...  
Keyword(s):  
Mouse Model ◽  
Factor Viii ◽  
Coagulation Factor ◽  
Coagulation Factor Viii ◽  
Φc31 Integrase ◽  
Tolerant Mouse

scholarly journals Analysis of a cholera toxin B subunit (CTB) and human mucin 1 (MUC1) conjugate protein in a MUC1-tolerant mouse model

2010 ◽  
Vol 59 (12) ◽  
pp. 1801-1811 ◽  
Author(s):  
Julia Pinkhasov ◽  
M. Lucrecia Alvarez ◽  
Latha B. Pathangey ◽  
Teresa L. Tinder ◽  
Hugh S. Mason ◽  
...  
Keyword(s):  
Mouse Model ◽  
Cholera Toxin ◽  
Cholera Toxin B Subunit ◽  
Mucin 1 ◽  
Toxin B ◽  
Cholera Toxin B ◽  
B Subunit ◽  
Tolerant Mouse

scholarly journals Zika viral infection and neutralizing human antibody response in a BLT humanized mouse model

Virology ◽  
2018 ◽  
Vol 515 ◽  
pp. 235-242 ◽  
Author(s):  
Kimberly Schmitt ◽  
Paige Charlins ◽  
Milena Veselinovic ◽  
Lauren Kinner-Bibeau ◽  
Shuang Hu ◽  
...  
Keyword(s):  
Mouse Model ◽  
Antibody Response ◽  
Viral Infection ◽  
Human Antibody ◽  
Humanized Mouse ◽  
Humanized Mouse Model

scholarly journals Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection

2015 ◽  
Vol 112 (28) ◽  
pp. 8738-8743 ◽  
Author(s):  
Kristen E. Pascal ◽  
Christopher M. Coleman ◽  
Alejandro O. Mujica ◽  
Vishal Kamat ◽  
Ashok Badithe ◽  
...  
Keyword(s):  
Mouse Model ◽  
Neutralizing Antibodies ◽  
Small Animal ◽  
Viral Disease ◽  
Human Antibody ◽  
Humanized Mouse ◽  
Humanized Mouse Model ◽  
In Vivo Testing ◽  
Rapid Generation

Traditional approaches to antimicrobial drug development are poorly suited to combatting the emergence of novel pathogens. Additionally, the lack of small animal models for these infections hinders the in vivo testing of potential therapeutics. Here we demonstrate the use of the VelocImmune technology (a mouse that expresses human antibody-variable heavy chains and κ light chains) alongside the VelociGene technology (which allows for rapid engineering of the mouse genome) to quickly develop and evaluate antibodies against an emerging viral disease. Specifically, we show the rapid generation of fully human neutralizing antibodies against the recently emerged Middle East Respiratory Syndrome coronavirus (MERS-CoV) and development of a humanized mouse model for MERS-CoV infection, which was used to demonstrate the therapeutic efficacy of the isolated antibodies. The VelocImmune and VelociGene technologies are powerful platforms that can be used to rapidly respond to emerging epidemics.

Hybrid transgenic immune tolerant mouse model for assessing the breaking of B cell tolerance by human interferon beta

2010 ◽  
Vol 352 (1-2) ◽  
pp. 32-37 ◽  
Author(s):  
Miranda M.C. van Beers ◽  
Melody Sauerborn ◽  
Francesca Gilli ◽  
Suzanne Hermeling ◽  
Vera Brinks ◽  
...  
Keyword(s):  
Mouse Model ◽  
B Cell ◽  
Interferon Beta ◽  
Human Interferon ◽  
Cell Tolerance ◽  
B Cell Tolerance ◽  
Immune Tolerant ◽  
Tolerant Mouse

scholarly journals FOXP3+TREGS THAT EXPRESSED CD127 EXISTING MEMORY TREGS FEATURE IN A TOLERANT MOUSE MODEL AND IN HUMAN SKIN

2020 ◽  
Vol 104 (S3) ◽  
pp. S155-S155
Author(s):  
Yuanfei Zhao ◽  
Thomas Oneil ◽  
Kirstie Bertram ◽  
Leigh Nicholson ◽  
Natasha Rogers ◽  
...  
Keyword(s):  
Mouse Model ◽  
Human Skin ◽  
Tolerant Mouse

Direct evidence that a human antibody derived from patient serum can promote myelin repair in a mouse model of chronic‐progressive demyelinating disease

2002 ◽  
Vol 16 (10) ◽  
pp. 1325-1327 ◽  
Author(s):  
Yoshihiro Mitsunaga ◽  
Bogoljub Ciric ◽  
Virginia Van Keulen ◽  
Arthur E. Warrington ◽  
M. Mateo Paz Soldan ◽  
...  
Keyword(s):  
Mouse Model ◽  
Direct Evidence ◽  
Demyelinating Disease ◽  
Human Antibody ◽  
Myelin Repair

A neonatally tolerant mouse model to assess pathogenicity of human autoantibodies

1990 ◽  
Vol 127 (2) ◽  
pp. 279-284 ◽  
Author(s):  
S. Mundlos ◽  
I.R. Mackay ◽  
I.H. Frazer ◽  
M. Rowley
Keyword(s):  
Mouse Model ◽  
Tolerant Mouse
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