Posttraumatic Stress Disorder and Cancer Risk: A Nested Case‐Control Study

2018 ◽  
Vol 31 (6) ◽  
pp. 919-926
Author(s):  
Elana Cohn ◽  
Ido Lurie ◽  
Yu‐Xiao Yang ◽  
Warren B. Bilker ◽  
Kevin Haynes ◽  
...  
PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e87117 ◽  
Author(s):  
Adriano R. Lima ◽  
Marcelo F. Mello ◽  
Sérgio B. Andreoli ◽  
Victor Fossaluza ◽  
Célia M. de Araújo ◽  
...  

2010 ◽  
Vol 39 (1) ◽  
pp. 85-92 ◽  
Author(s):  
Leddy Marina Contreras-Pezzotti ◽  
Juan Ernesto Arteaga-Medina ◽  
José Fidel Latorre ◽  
Jorge Óscar Folino ◽  
Adalberto Campo-Arias

2021 ◽  
Author(s):  
Samuel Cyr ◽  
Marie-Joëlle Marcil ◽  
Valérie Long ◽  
Corrado De Marco ◽  
Katia Dyrda ◽  
...  

AbstractIntroductionA large body of evidence indicates a significant and morbid association between posttraumatic stress disorder (PTSD) and cardiovascular disease (CVD). Few studies, however, have addressed the range of trauma in this medical population, from massive heart attack, to defibrillator shock to previous interpersonal aggression.ObjectiveThe main objective of this study was to examine the nature of trauma associated with the development of PTSD in CVD patients. More precisely, we were interested in knowing if trauma was medical in nature and whether cumulative trauma resulted in PTSD.MethodsWe performed a 1:3 case-control study. The authors compared CVD patients diagnosed with PTSD (n=37) to those with adjustment disorder (n=111) in terms of trauma/stressor types and medical and demographic characteristics.ResultsHalf (51%) of CVD patients suffering from PTSD had endured a medical trauma, 35% an external (non-medical) trauma, and 14% both. There were no significant differences with CVD patients diagnosed with adjustment disorder, 40% of them having experienced a medical stressor, 40% an external (non-medical) stressor and 20% both. Cumulative trauma was seen in only 19% of CVD patients suffering from PTSD. Traditional risk factors (female sex, younger age) were not prominent in CVD patients with PTSD as compared to those with adjustment disorder. Cases were, however, significantly more likely to have psychiatric antecedents and recent surgical interventions.ConclusionsBy uncovering characteristics of PTSD patients/trauma in CVD patients, this work will serve future research and clinical initiatives to better screen at-risk patients or at-risk medical situations.


Author(s):  
Valent�n Rodr�guez ◽  
Adonina Tard�n ◽  
Manolis Kogevinas ◽  
Carlos S. Prieto ◽  
Antonio Cueto ◽  
...  

2006 ◽  
Vol 66 (20) ◽  
pp. 10213-10219 ◽  
Author(s):  
Rachael Z. Stolzenberg-Solomon ◽  
Reinhold Vieth ◽  
Azar Azad ◽  
Pirjo Pietinen ◽  
Philip R. Taylor ◽  
...  

Author(s):  
Cheng Peng ◽  
Chi Gao ◽  
Donghao Lu ◽  
Bernard A Rosner ◽  
Oana Zeleznik ◽  
...  

ABSTRACT Background Carotenoids represent 1 of few modifiable factors to reduce breast cancer risk. Elucidation of interactions between circulating carotenoids and genetic predispositions or mammographic density (MD) may help inform more effective primary preventive strategies in high-risk populations. Objectives We tested whether women at high risk for breast cancer due to genetic predispositions or high MD would experience meaningful and greater risk reduction from higher circulating levels of carotenoids in a nested case-control study in the Nurses’ Health Studies (NHS and NHSII). Methods This study included 1919 cases and 1695 controls in a nested case-control study in the NHS and NHSII. We assessed both multiplicative and additive interactions. RR reductions and 95% CIs were calculated using unconditional logistic regressions, adjusting for matching factors and breast cancer risk factors. Absolute risk reductions (ARR) were calculated based on Surveillance, Epidemiology, and End Results incidence rates. Results We showed that compared with women at low genetic risk or low MD, those with higher genetic risk scores or high MD had greater ARRs for breast cancer as circulating carotenoid levels increase (additive P-interaction = 0.05). Among women with a high polygenic risk score, those in the highest quartile of circulating carotenoids had a significant ARR (28.6%; 95% CI, 14.8–42.1%) compared to those in the lowest quartile of carotenoids. For women with a high percentage MD (≥50%), circulating carotenoids were associated with a 37.1% ARR (95% CI, 21.7–52.1%) when comparing the highest to the lowest quartiles of circulating carotenoids. Conclusions The inverse associations between circulating carotenoids and breast cancer risk appeared to be more pronounced in high-risk women, as defined by germline genetic makeup or MD.


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