scholarly journals Central Diabetes Insipidus and Cisplatin-Induced Renal Salt Wasting Syndrome: A Challenging Combination

2016 ◽  
Vol 63 (5) ◽  
pp. 925-927 ◽  
Author(s):  
Gerard Cortina ◽  
Jordan R. Hansford ◽  
Trevor Duke
Keyword(s):  
Diabetes Insipidus ◽  
Central Diabetes Insipidus ◽  
Salt Wasting ◽  
Renal Salt Wasting ◽  
Wasting Syndrome ◽  
Salt Wasting Syndrome

Combined Central Diabetes Insipidus and Cerebral Salt Wasting Syndrome in Children

2009 ◽  
Vol 40 (2) ◽  
pp. 84-87 ◽  
Author(s):  
Jainn-Jim Lin ◽  
Kuang-Lin Lin ◽  
Shao-Hsuan Hsia ◽  
Chang-Teng Wu ◽  
Huei-Shyong Wang
Keyword(s):  
Diabetes Insipidus ◽  
Central Diabetes Insipidus ◽  
Cerebral Salt Wasting Syndrome ◽  
Cerebral Salt Wasting ◽  
Salt Wasting ◽  
Wasting Syndrome ◽  
Salt Wasting Syndrome

scholarly journals Carboplatin-induced Renal Salt Wasting Syndrome in Paediatric Patients with Intracranial Germ Cell Tumours and Concomitant Diabetes Insipidus

2021 ◽  
Author(s):  
Tania Wan ◽  
Joanna Tung ◽  
Samantha Lee ◽  
Alison LT Ma ◽  
Anthony Pak Yin Liu ◽  
...  
Keyword(s):  
Germ Cell ◽  
Diabetes Insipidus ◽  
Germ Cell Tumour ◽  
Case Series ◽  
Salt Wasting ◽  
Renal Salt Wasting ◽  
Wasting Syndrome ◽  
First Case ◽  
Platinum Based Chemotherapy ◽  
Salt Wasting Syndrome

We report the first case series of 14 children with intracranial germ cell tumour (iGCT) and concomitant central diabetes insipidus (DI), who developed hyponatremia secondary to renal salt wasting syndrome (RSWS) following the administration of carboplatin. Clinicians prescribing platinum-based chemotherapy for this group of patients should be alert to the risk of RSWS. Regular monitoring should be performed as hyponatraemia can be asymptomatic until it is severe.

scholarly journals Coexisting Cerebral Salt Wasting Syndrome and Central Diabetes Insipidus in a Patient with Posterior Cerebrovascular Infarction: A Case Report

2021 ◽  
pp. 1-5
Author(s):  
Mohamad A.E. Omar ◽  
Hesham F. Kewan ◽  
Hussein Kandeel ◽  
Ammar M.H. Shehadeh
Keyword(s):  
Diabetes Insipidus ◽  
Early Recognition ◽  
Central Diabetes Insipidus ◽  
Sodium Balance ◽  
Cerebral Salt Wasting Syndrome ◽  
Cerebral Salt Wasting ◽  
Salt Wasting ◽  
Wasting Syndrome ◽  
Volume State ◽  
Salt Wasting Syndrome

<b><i>Background:</i></b> Disorders of sodium balance are common in critically ill neurologic patients. However, the coexisting of cerebral salt wasting syndrome (CSW) and central diabetes insipidus (CDI) in such patients is rare. Early recognition of such conditions is challenging, thus making the prognosis ominous. <b><i>Case Presentation:</i></b> A 50-year-old male patient presented with acute posterior cerebrovascular infarction complicated by several attacks of disturbed sodium homeostasis. The first attack manifested as hypernatremia (up to 161 mmol/L) and polyuria with high urine sodium (188 mmol/L) could only be explained by CSW on top of CDI. Especially the patient was not receiving any hyperosmolar or sodium-containing fluids. Serum sodium was corrected by desmopressin acetate. Later, the patient developed 2 attacks of hyponatremia (down to 119 mmol/L) diagnosed as CSW that was treated with fludrocortisone. Finally, he developed hypernatremia (up to 165 mmol/L) diagnosed as CDI and was treated with desmopressin acetate. <b><i>Conclusion:</i></b> Sodium hemostasis disorders require full consideration of serum electrolytes, intravascular volume state, and urine electrolytes in view of the clinical condition. Early diagnosis and administration of the proper treatment are the cornerstones of successful management.

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