OP19.01: The effects of nitric oxide donors on uterine artery blood flow in recurrent implantation failure and pregnancy rate

Abstract Preeclampsia is a pregnancy-related hypertensive disorder with unclear mechanisms. While hypersensitivity to angiotensin II via vasoconstrictive angiotensin type-1 receptor (AT1R) is observed in preeclampsia, the importance of vasodilatory angiotensin type-2 receptor (AT2R) in the control of vascular dysfunction is less clear. We assessed whether AT1R, AT2R and eNOS expression is altered in placental vessels of preeclamptic women and tested if ex vivo incubation with AT2R agonist Compound 21 (C21; 1 μM) could restore AT1R, AT2R and eNOS balance. Further, using a rat model of gestational hypertension induced by elevated testosterone, we examined whether C21 (1 μg·kg−1·day−1, oral) could preserve AT1R and AT2R balance and improve blood pressure, uterine artery blood flow, and vascular function. Western blots revealed that AT1R protein level was higher while AT2R and eNOS protein were reduced in preeclamptic placental vessels, and AT2R agonist C21 decreased AT1R and increased AT2R and eNOS protein levels in preeclamptic vessels. In testosterone-dams, blood pressure was higher, and uterine artery blood flow was reduced, and C21 treatment reversed these levels similar to those in controls dams. C21 attenuated the exaggerated Ang II contraction and improved endothelium-dependent vasorelaxation in uterine arteries of testosterone-dams. These C21-mediated vascular effects were associated with decreased AT1R and increased AT2R and eNOS protein levels. C21 also increased serum nitrate/nitrite and bradykinin production in testosterone-dams and attenuated the feto-placental growth restriction. Thus, AT1R upregulation and AT2R downregulation is observed in preeclampsia and testosterone-model, and increasing AT2R activity could help restore AT1R and AT2R balance and improve gestational vascular function.

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Comparison of uterine artery blood flow with levonorgestrel intrauterine system and copper intrauterine device

Contraception ◽

10.1016/j.contraception.2010.09.001 ◽

2011 ◽

Vol 83 (6) ◽

pp. 578-581 ◽

Cited By ~ 5

Author(s):

Berna Haliloglu ◽

Aygen Celik ◽

Erdin Ilter ◽

Serpil Bozkurt ◽

Umit Ozekici

Keyword(s):

Blood Flow ◽

Uterine Artery ◽

Intrauterine Device ◽

Artery Blood Flow ◽

Copper Intrauterine Device

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Clinical significance of uterine artery blood flow velocity waveforms during provoked uterine contractions in high-risk pregnancy

Ultrasound in Obstetrics and Gynecology ◽

10.1002/uog.1708 ◽

2004 ◽

Vol 24 (4) ◽

pp. 429-434 ◽

Cited By ~ 7

Author(s):

H. Li ◽

S. Gudmundsson ◽

P. Olofsson

Keyword(s):

Blood Flow ◽

High Risk ◽

Flow Velocity ◽

Clinical Significance ◽

Blood Flow Velocity ◽

Uterine Artery ◽

High Risk Pregnancy ◽

Artery Blood Flow ◽

Uterine Contractions ◽

Risk Pregnancy

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The Effects of Acupuncture on Pregnancy Outcomes of Recurrent Implantation Failure: A Systematic Review and Meta-Analysis

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2021/6661235 ◽

2021 ◽

Vol 2021 ◽

pp. 1-11

Author(s):

Menglin Li ◽

Yunyun Liu ◽

Haoran Wang ◽

Shuzhen Zheng ◽

Yinhe Deng ◽

...

Keyword(s):

Pregnancy Rate ◽

Assessment Tool ◽

Meta Analysis ◽

Intervention Group ◽

Control Group ◽

Implantation Failure ◽

Recurrent Implantation Failure ◽

The Difference ◽

Ivf Et

Objective. To systematically evaluate the efficacy and safety of acupuncture for patients with recurrent implantation failure (RIF) undergoing in vitro fertilization-embryo transfer (IVF-ET) and hopefully provide reliable guidance for clinicians and patients. Methods. Through searching domestic and foreign medical journals, the literature of randomized controlled trials (RCTs) of acupuncture for RIF undergoing IVF-ET was collected. RevMan 5.3 software was used for meta-analysis and Cochrane’s risk of bias assessment tool was used to evaluate the quality of the included studies. Results. Seven documents meeting the criteria were finally included. The results showed that the intervention group contributes more in outcomes including clinical pregnancy rate (RR = 1.90, 95% CI (1.51, 2.40), P < 0.05 ), biochemical pregnancy rate (RR = 1.59, 95% CI (1.27, 1.99), P < 0.05 ), embryo implantation rate (RR = 1.89, 95% CI (1.47, 2.45), P < 0.05 ), and endometrial thickness (MD = 1.11, 95% CI (0.59, 1.63), P < 0.05 ) when compared with the control group, and the difference is statistically significant. In terms of the number of embryo transfers and the type of endometrium, the difference between the acupuncture group and the control group was not statistically significant. Conclusion. Acupuncture therapy on patients with RIF can improve the pregnancy outcome of patients. It is a relatively effective treatment with satisfactory safety and suitable for clinical application. However, as the quality of the included studies is not good enough, the conclusion of this meta-analysis should be treated with caution. More double-blind RCTs equipped with high quality and large samples are expected for the improvement of the level of evidence.

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