Melatonin Inhibits LDL Receptor Activity and Cholesterol-Synthesis in Freshly Isolated Human Mononuclear Leukocytes

1994 ◽  
Vol 203 (1) ◽  
pp. 416-421 ◽  
Author(s):  
D. Mullerwieland ◽  
B. Behnke ◽  
K. Koopmann ◽  
W. Krone
Keyword(s):  
Cholesterol Synthesis ◽  
Ldl Receptor ◽  
Receptor Activity ◽  
Mononuclear Leukocytes ◽  
Human Mononuclear Leukocytes

Opposite Effects of Insulin and Catecholamines on LDL-Receptor Activity in Human Mononuclear Leukocytes

Diabetes ◽  
1988 ◽  
Vol 37 (10) ◽  
pp. 1386-1391 ◽  
Author(s):  
W. Krone ◽  
H. Naegele ◽  
B. Behnke ◽  
H. Greten
Keyword(s):  
Ldl Receptor ◽  
Receptor Activity ◽  
Mononuclear Leukocytes ◽  
Human Mononuclear Leukocytes

scholarly journals Cholesterol metabolism. Effect of 26-thiacholesterol and 26-aminocholesterol, analogues of 26-hydroxycholesterol, on cholesterol synthesis and low-density-lipoprotein-receptor binding

1988 ◽  
Vol 255 (3) ◽  
pp. 1049-1052 ◽  
Author(s):  
E Miao ◽  
S R Wilson ◽  
N B Javitt
Keyword(s):  
Cholesterol Synthesis ◽  
Low Density Lipoprotein ◽  
Human Fibroblasts ◽  
Ldl Receptor ◽  
Density Lipoprotein ◽  
Receptor Activity ◽  
Lipoprotein Receptor ◽  
Hep G2 ◽  
Hep G2 Cells ◽  
Density Lipoprotein Receptor

1. The effects of 26-aminocholesterol and 26-thiacholesterol on cholesterol synthesis and LDL (low-density lipoprotein)-receptor activity were compared with naturally occurring 26-hydroxycholesterol utilizing both human fibroblasts and hepatoma (Hep G2) cells. 2. At equimolar concentrations (0.625 microM), down-regulation of LDL-receptor activity and cholesterol synthesis was greater with human fibroblasts than with Hep G2 cells. 3. At much higher concentrations (5-20 microM) the 26-thia analogue had little effect on either cholesterol synthesis or LDL-receptor activity.

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