Flow Chemistry as an Enabling Technology for Synthetic Organic Chemistry

2021 ◽  
pp. 489-526
Author(s):  
Nicholas E. Leadbeater
Keyword(s):  
Organic Chemistry ◽  
Flow Chemistry ◽  
Enabling Technology ◽  
Synthetic Organic Chemistry

scholarly journals Electrocatalysis as an enabling technology for organic synthesis

2021 ◽  
Author(s):  
Luiz F. T. Novaes ◽  
Jinjian Liu ◽  
Yifan Shen ◽  
Lingxiang Lu ◽  
Jonathan M. Meinhardt ◽  
...  
Keyword(s):  
Organic Chemistry ◽  
Organic Synthesis ◽  
Enabling Technology ◽  
Synthetic Organic Chemistry

Electrochemistry has recently gained increased attention as a versatile strategy for achieving challenging transformations at the forefront of synthetic organic chemistry.

Room Temperature Flow Electrochemistry as a Means of Retaining the “Memory of Chirality” via Hofer Moest Type Reaction

2020 ◽  
Author(s):  
Tomas Hardwick ◽  
Rossana Cicala ◽  
Nisar Ahmed
Keyword(s):  
Continuous Flow ◽  
Room Temperature ◽  
Biological Activities ◽  
Supporting Electrolyte ◽  
Enantiomeric Excess ◽  
Flow Chemistry ◽  
Batch Processes ◽  
Enabling Technology ◽  
Chiral Compounds ◽  
Memory Of Chirality

<p>Many chiral compounds have become of great interest to the pharmaceutical industry as they possess various biological activities. Concurrently, the concept of “memory of chirality” has been proven as a powerful tool in asymmetric synthesis, while flow chemistry has begun its rise as a new enabling technology to add to the ever increasing arsenal of techniques available to the modern day chemist. Here, we have employed a new simple electrochemical microreactor design to oxidise an L-proline derivative at room temperature in continuous flow. Flow performed in microreactors offers up a number of benefits allowing reactions to be performed in a more convenient and safer manner, and even allow electrochemical reactions to take place without a supporting electrolyte due to a very short interelectrode distance. By the comparison of electrochemical oxidations in batch and flow we have found that continuous flow is able to outperform its batch counterpart, producing a good yield (71%) and a better enantiomeric excess (64%) than batch with a 98% conversion. We have, therefore, provided evidence that continuous flow chemistry has the potential to act as a new enabling technology to replace some aspects of conventional batch processes. </p>

Recent Developments in the Asymmetric Detrifluoroacetylative Reactions of in situ Generated Mono-Fluorinated Enolates

2020 ◽  
Vol 24 (18) ◽  
pp. 2181-2191
Author(s):  
Li Wang ◽  
Ziyi Li ◽  
Jiang Liu ◽  
Jianlin Han ◽  
Hiroki Moriwaki ◽  
...  
Keyword(s):  
Organic Chemistry ◽  
Bond Cleavage ◽  
Synthetic Methodology ◽  
Research Topics ◽  
Synthetic Organic Chemistry ◽  
Nucleophilic Reactions ◽  
F Center ◽  
Recent Developments

The development of an efficient and mild synthetic methodology for the construction of bioactive fluorine-containing molecules represents one of the hot research topics in general synthetic organic chemistry. In this review, some recent progresses achieved in the development of detrifluoroacetylatively generated mono-fluorinated enolates via CC bond cleavage and their asymmetric nucleophilic reactions for assembly of chiral quaternary C-F center containing compounds.

An approach to computer-assisted drill in synthetic organic chemistry

1973 ◽  
Vol 50 (9) ◽  
pp. 645
Author(s):  
H. A. Clark ◽  
J. C. Marshall ◽  
T. L. Isenhour
Keyword(s):  
Organic Chemistry ◽  
Computer Assisted ◽  
Synthetic Organic Chemistry

Recent advances and perspectives in manganese-catalyzed C–H activation

2021 ◽  
Author(s):  
Thaipparambil Aneeja ◽  
Mohan Neetha ◽  
C. M. A. Afsina ◽  
Gopinathan Anilkumar
Keyword(s):  
Organic Chemistry ◽  
Synthetic Organic Chemistry ◽  
Recent Advances

Manganese-catalyzed C–H activation has become an emerging area in organic chemistry. These efficient and eco-friendly manganese catalysed reactions provides new opportunities in the field of synthetic organic chemistry.

A review of the recent progress on heterogeneous catalysts for Knoevenagel condensation

2021 ◽  
Vol 50 (13) ◽  
pp. 4445-4469
Author(s):  
Jimmy Nelson Appaturi ◽  
Rajni Ratti ◽  
Bao Lee Phoon ◽  
Samaila Muazu Batagarawa ◽  
Israf Ud Din ◽  
...  
Keyword(s):  
Organic Chemistry ◽  
Green Chemistry ◽  
Heterogeneous Catalysts ◽  
Recent Progress ◽  
Knoevenagel Condensation ◽  
Sustainable Production ◽  
Organic Reactions ◽  
Synthetic Organic Chemistry

One of the most crucial attributes of synthetic organic chemistry is to design organic reactions under the facets of green chemistry for the sustainable production of chemicals.

Functional Analysis of Glycoprotein Oligosaccharide Through Synthetic Organic Chemistry

ChemInform ◽  
2006 ◽  
Vol 37 (42) ◽  
Author(s):  
Kiichiro Totani ◽  
Shinya Hagihara ◽  
Yukishige Ito
Keyword(s):  
Organic Chemistry ◽  
Functional Analysis ◽  
Synthetic Organic Chemistry
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