Development of a High-Power Water-Cooled Beryllium Target for use in Accelerator-Based Boron Neutron Capture Therapy

2001 ◽  
pp. 449-453
Author(s):  
Brandon W. Blackburn ◽  
Jacquelyn C. Yanch ◽  
Robert E. Klinkowstein
Keyword(s):  
High Power ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture ◽  
Beryllium Target

High-power liquid-lithium target prototype for accelerator-based boron neutron capture therapy

2011 ◽  
Vol 69 (12) ◽  
pp. 1654-1656 ◽  
Author(s):  
S. Halfon ◽  
M. Paul ◽  
A. Arenshtam ◽  
D. Berkovits ◽  
M. Bisyakoev ◽  
...  
Keyword(s):  
High Power ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Liquid Lithium ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture ◽  
Lithium Target

scholarly journals HGG-05. REGRESSION OF RECURRENT GLIOBLASTOMA AFTER BORON NEUTRON CAPTURE THERAPY AND CHIMERIC ANTIGEN RECEPTOR T-CELL THERAPY IN A CHILD

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii345-iii345
Author(s):  
Hsin-Hung Chen ◽  
Yi-Wei Chen
Keyword(s):  
T Cells ◽  
T Cell ◽  
Chimeric Antigen Receptor ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Antigen Receptor ◽  
Neutron Capture Therapy ◽  
T Cell Therapy ◽  
Boron Neutron Capture ◽  
Car T

Abstract A 6 y/o girl with recurrent multifocal glioblastoma received 3 times of boron neutron capture therapy (BNCT) and chimeric antigen receptor (CAR)–engineered T cells targeting the tumor-associated antigen HER2. Multiple infusions of CAR T cells were administered over 30 days through intraventricular delivery routes. It was not associated with any toxic effects of grade 3 or higher. After BNCT and CAR T-cell treatment, regression of all existing intracranial lesions were observed, along with corresponding increases in levels of cytokines and immune cells in the cerebrospinal fluid, but new lesions recurred soon after the treatment. This clinical response continued for 14 months after the initiation of first recurrence.

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