Lab-on-a-Chip Devices and Micro-Total Analysis Systems

The Analyst ◽  
2016 ◽  
Vol 141 (12) ◽  
pp. 3511-3525 ◽  
Author(s):  
C. M. Gabardo ◽  
L. Soleymani

Rapid prototyping is a critical step in the product development cycle of miniaturized chemical and bioanalytical devices, often categorized as lab-on-a-chip devices, biosensors, and micro-total analysis systems.


Author(s):  
Yiou Wang ◽  
Jiang Zhe ◽  
Prashanta Dutta ◽  
Gary J. Cheng

Numerical study on a rapid micromixer based on hybrid electrokinetic relay and asymmetric serpentine structures is presented. Effective mixing of liquids is essential in many applications such as drug delivery, DNA analysis/sequencing, pheromone synthesis in micro bioreactors, and biological/chemical agent detections. Rapid mixing can reduce the analysis time and permit high throughput in lab-on-a-chip or micro total analysis systems (μTAS). The proposed hybrid mixing takes advantages of both mixing enhancements induced by asymmetric flow geometries and the electrokinetic relay actuating. Simulation results show that the micro mixer is able to achieve high mixing efficiencies (94.3%) in short time (1.2s). Effects of relay frequency, electric field and channel geometry on micro-mixing have been conducted. Numerical results show that electrokinetic relay at an appropriate frequency causes effective micromixing. Moreover asymmetric flow geometries are critical for ultra effective mixing.


Author(s):  
Darwin R. Reyes ◽  
Henne van Heeren

In the last two decades, the microfluidics/lab-on-a-chip field has evolved from the concept of micro total analysis systems, where systems with integrated pretreatment and analysis of chemicals were envisioned, to what is known today as lab-on-a-chip, which is expected to be modular. This field has shown great potential for the development of technologies that can make, and to some extent are making, a big difference in areas such as in vitro diagnostics, point of care testing, organ on a chip, and many more. Microfluidics plays an essential role in these systems, and determining the standards needed in this area is critical for enabling new markets and products, and to advance research and development. Our goal was to bring together stakeholders from industry, academia, and government to discuss and define the needs within the field for the development of standards. This publication contains a summary of the workshop, abstracts from each presentation, and a summary of the breakout sessions from the National Institute of Standards and Technology Workshop on Standards for Microfluidics, held on June 1–2, 2017. The workshop was attended by 46 persons from 26 organizations and 11 countries. This was a unique and exciting opportunity for stakeholders from all over the world to join in the discussion of future developments towards standardization in the microfluidics arena.


Author(s):  
Arvind Chandrasekaran ◽  
Muthukumaran Packirisamy

In this work, a Piezo actuated Valveless micropump is proposed for applications in Micro-Total Analysis Systems (μTAS) and Lab-on-a-Chip. Flow rectification in the micropump has been brought about with the use of a diffuser element. The device is fabricated on PDMS-Glass substrate with the glass acting as the diaphragm. A PZT disc is integrated with the setup for actuation. The micropump has been characterized for its dynamic behavior, flow characteristics, and pressure. It was found that the maximum flow rate for the micropump was obtained at low frequency which makes it usable for practical μTAS applications.


Lab on a Chip ◽  
2020 ◽  
Vol 20 (8) ◽  
pp. 1426-1440
Author(s):  
M. Shane Woolf ◽  
Leah M. Dignan ◽  
Hannah M. Lewis ◽  
Christopher J. Tomley ◽  
Aeren Q. Nauman ◽  
...  

Microvalving is a pivotal component in many microfluidic lab-on-a-chip platforms and micro-total analysis systems (μTAS).


2021 ◽  
pp. 129859
Author(s):  
Tao Tang ◽  
Yapeng Yuan ◽  
Yaxiaer Yalikun ◽  
Yochiroh Hosokawa ◽  
Ming Li ◽  
...  

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