A Hybrid Rapid Microfluidic Mixer Utilizing Electrokinetic Relay and Asymmetric Flow Geometries for Lab-on-a-Chip Applications

2005 ◽  
Author(s):  
Yiou Wang ◽  
Jiang Zhe ◽  
Prashanta Dutta ◽  
Gary J. Cheng
Keyword(s):  
Dna Analysis ◽  
Numerical Study ◽  
Lab On A Chip ◽  
Chemical Agent ◽  
Asymmetric Flow ◽  
Microfluidic Mixer ◽  
Micro Total Analysis Systems ◽  
Total Analysis ◽  
Short Time ◽  
Micro Mixer

Numerical study on a rapid micromixer based on hybrid electrokinetic relay and asymmetric serpentine structures is presented. Effective mixing of liquids is essential in many applications such as drug delivery, DNA analysis/sequencing, pheromone synthesis in micro bioreactors, and biological/chemical agent detections. Rapid mixing can reduce the analysis time and permit high throughput in lab-on-a-chip or micro total analysis systems (μTAS). The proposed hybrid mixing takes advantages of both mixing enhancements induced by asymmetric flow geometries and the electrokinetic relay actuating. Simulation results show that the micro mixer is able to achieve high mixing efficiencies (94.3%) in short time (1.2s). Effects of relay frequency, electric field and channel geometry on micro-mixing have been conducted. Numerical results show that electrokinetic relay at an appropriate frequency causes effective micromixing. Moreover asymmetric flow geometries are critical for ultra effective mixing.

Deposition, patterning, and utility of conductive materials for the rapid prototyping of chemical and bioanalytical devices

The Analyst ◽  
2016 ◽  
Vol 141 (12) ◽  
pp. 3511-3525 ◽  
Author(s):  
C. M. Gabardo ◽  
L. Soleymani
Keyword(s):  
Product Development ◽  
Rapid Prototyping ◽  
Lab On A Chip ◽  
Critical Step ◽  
Conductive Materials ◽  
Development Cycle ◽  
Micro Total Analysis Systems ◽  
Total Analysis ◽  
Product Development Cycle

Rapid prototyping is a critical step in the product development cycle of miniaturized chemical and bioanalytical devices, often categorized as lab-on-a-chip devices, biosensors, and micro-total analysis systems.

scholarly journals Proceedings of the First Workshop on Standards for Microfluidics

2019 ◽  
Vol 124 ◽  
Author(s):  
Darwin R. Reyes ◽  
Henne van Heeren
Keyword(s):  
Point Of Care ◽  
Lab On A Chip ◽  
In Vitro Diagnostics ◽  
Point Of Care Testing ◽  
Future Developments ◽  
Exciting Opportunity ◽  
Micro Total Analysis Systems ◽  
Advance Research ◽  
Total Analysis

In the last two decades, the microfluidics/lab-on-a-chip field has evolved from the concept of micro total analysis systems, where systems with integrated pretreatment and analysis of chemicals were envisioned, to what is known today as lab-on-a-chip, which is expected to be modular. This field has shown great potential for the development of technologies that can make, and to some extent are making, a big difference in areas such as in vitro diagnostics, point of care testing, organ on a chip, and many more. Microfluidics plays an essential role in these systems, and determining the standards needed in this area is critical for enabling new markets and products, and to advance research and development. Our goal was to bring together stakeholders from industry, academia, and government to discuss and define the needs within the field for the development of standards. This publication contains a summary of the workshop, abstracts from each presentation, and a summary of the breakout sessions from the National Institute of Standards and Technology Workshop on Standards for Microfluidics, held on June 1–2, 2017. The workshop was attended by 46 persons from 26 organizations and 11 countries. This was a unique and exciting opportunity for stakeholders from all over the world to join in the discussion of future developments towards standardization in the microfluidics arena.

Piezo-Actuated Valveless Micropumps for Micro-Total Analysis Systems

2010 ◽  
Author(s):  
Arvind Chandrasekaran ◽  
Muthukumaran Packirisamy
Keyword(s):  
Flow Rate ◽  
Glass Substrate ◽  
Flow Characteristics ◽  
Low Frequency ◽  
Lab On A Chip ◽  
Maximum Flow ◽  
Valveless Micropump ◽  
Chip Flow ◽  
Micro Total Analysis Systems ◽  
Total Analysis

In this work, a Piezo actuated Valveless micropump is proposed for applications in Micro-Total Analysis Systems (μTAS) and Lab-on-a-Chip. Flow rectification in the micropump has been brought about with the use of a diffuser element. The device is fabricated on PDMS-Glass substrate with the glass acting as the diaphragm. A PZT disc is integrated with the setup for actuation. The micropump has been characterized for its dynamic behavior, flow characteristics, and pressure. It was found that the maximum flow rate for the micropump was obtained at low frequency which makes it usable for practical μTAS applications.

Optically-controlled closable microvalves for polymeric centrifugal microfluidic devices

Lab on a Chip ◽  
2020 ◽  
Vol 20 (8) ◽  
pp. 1426-1440
Author(s):  
M. Shane Woolf ◽  
Leah M. Dignan ◽  
Hannah M. Lewis ◽  
Christopher J. Tomley ◽  
Aeren Q. Nauman ◽  
...  
Keyword(s):  
Lab On A Chip ◽  
Microfluidic Devices ◽  
Micro Total Analysis Systems ◽  
Total Analysis

Microvalving is a pivotal component in many microfluidic lab-on-a-chip platforms and micro-total analysis systems (μTAS).

Rapid Detection of Methanol in an Integration Microfluidic Chip

2011 ◽  
Vol 483 ◽  
pp. 364-369
Author(s):  
Yao Nan Wang ◽  
Ching Liang Liou ◽  
Ming Chang Wu ◽  
Chien Hsiung Tsai ◽  
Lung Ming Fu
Keyword(s):  
Microfluidic Chip ◽  
Rapid Detection ◽  
Simple Technique ◽  
Effective Solution ◽  
Basic Fuchsin ◽  
Micro Total Analysis Systems ◽  
Total Analysis ◽  
Methanol Oxidase ◽  
Micro Mixer ◽  
Current Device

A rapid and simple technique was developed for detecting methanol with very small amount of sample by using PMMA (Polymethyl-Methacrylate) microfluidic chip, which fabricated by a commercially available CO2 laser scriber. The experimental results indicate that linearity expression R2 can approximate 0.936 using the proposed integrating microfluidic chip when the 2 unit methanol oxidase (MOX) and basic fuchsin to detect methanol. Hence, the current device provides a valuable tool for rapid methanol detection, while its micro mixer system delivers a simple yet effective solution for mixing problems in the micro-total-analysis -systems field.

Numerical study of isotropic ocean swell

2019 ◽  
Vol 489 (5) ◽  
pp. 512-516
Author(s):  
V. V. Geogjaev ◽  
V. E. Zakharov ◽  
S. I. Badulin
Keyword(s):  
Numerical Study ◽  
Short Time ◽  
Kolmogorov Constant

A new algorithm is used for detailed numerical study of the evolution of isotropic swell in a homogeneous ocean. It is shown that the Zakharov-Filonenko spectrum occurs in an explosive manner in a short time. The Kolmogorov constant of the solution is estimated numerically.

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