Modeling of the Human Bronchial Tree and Simulation of Internal Airflow: A Review

Author(s):  
Yijuan Di ◽  
Minrui Fei ◽  
Xin Sun ◽  
T. C. Yang
Keyword(s):  
2021 ◽  
Author(s):  
Adam B. Lawson ◽  
Brandon P. Hedrick ◽  
M. Scott Echols ◽  
Emma R. Schachner

Cancers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 3463
Author(s):  
Mark Farrugia ◽  
Sung Jun Ma ◽  
Mark Hennon ◽  
Chukwumere Nwogu ◽  
Elisabeth Dexter ◽  
...  

The preferred radiotherapeutic approach for central (CLT) and ultracentral (UCLT) lung tumors is unclear. We assessed the toxicity and outcomes of patients with CLT and UCLT who underwent definitive five-fraction stereotactic body radiation therapy (SBRT). We reviewed the charts of patients with either CLT or UCLT managed with SBRT from June 2010–April 2019. CLT were defined as gross tumor volume (GTV) within 2 cm of either the proximal bronchial tree, trachea, mediastinum, aorta, or spinal cord. UCLT were defined as GTV abutting any of these structures. Propensity score matching was performed for gender, performance status, and history of prior lung cancer. Within this cohort of 83 patients, 43 (51.8%) patients had UCLT. The median patient age was 73.1 years with a median follow up of 29.9 months. The two most common dose fractionation schemes were 5000 cGy (44.6%) and 5500 cGy (42.2%) in five fractions. Multivariate analysis revealed UCLT to be associated with worse overall survival (OS) (HR = 1.9, p = 0.02) but not time to progression (TTP). Using propensity score match pairing, UCLT correlated with reduced non-cancer associated survival (p = 0.049) and OS (p = 0.03), but not TTP. Within the matched cohort, dosimetric study found exceeding a D4cc of 18 Gy to either the proximal bronchus (HR = 3.9, p = 0.007) or trachea (HR = 4.0, p = 0.02) was correlated with worse non-cancer associated survival. In patients undergoing five fraction SBRT, UCLT location was associated with worse non-cancer associated survival and OS, which could be secondary to excessive D4cc dose to the proximal airways.


Thorax ◽  
1996 ◽  
Vol 51 (2) ◽  
pp. 226-227
Author(s):  
M. R. Hetzel
Keyword(s):  

Nature ◽  
1962 ◽  
Vol 195 (4842) ◽  
pp. 715-716 ◽  
Author(s):  
LYNNE REID ◽  
C. McCARTHY ◽  
JALE DUVENCI ◽  
R. A. GIBBONS
Keyword(s):  

2008 ◽  
Vol 47 (19) ◽  
pp. 1695-1698 ◽  
Author(s):  
Maki Bunno ◽  
Masanori Kawaguchi ◽  
Kunihiro Yamahara ◽  
Chieri Kanda

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