The Biological Effects of Carbon Nanotubes in Plasma Membranes Damage, DNA Damage, and Mitochondrial Dysfunction

2015 ◽  
pp. 179-188
Author(s):  
Zhuo Zhao ◽  
Zhi-Peng Liu ◽  
Hua Wang ◽  
Feng-Juan Liu ◽  
Hui Zhang ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Dna Damage ◽  
Mitochondrial Dysfunction ◽  
Plasma Membranes ◽  
Biological Effects

scholarly journals Transcriptome profiling of cells exposed to particular and intense electromagnetic radiation emitted by the "SG-III" prototype laser facility

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jiangbin Wei ◽  
Qiwu Shi ◽  
Lidan Xiong ◽  
Guang Xin ◽  
Tao Yi ◽  
...  
Keyword(s):  
Dna Damage ◽  
Pc12 Cells ◽  
Inertial Confinement Fusion ◽  
Biological Effects ◽  
Harmful Effect ◽  
Transcriptome Profiling ◽  
Target Chamber ◽  
Target Range ◽  
Inertial Confinement ◽  
Laser Facility

AbstractThe experiment of inertial confinement fusion by the “ShengGuang (SG)-III” prototype laser facility is a transient and extreme reaction process within several nanoseconds, which could form a very complicated and intense electromagnetic field around the target chamber of the facility and may lead to harmful effect on people around. In particular, the biological effects arising from such specific environment field could hardly be ignored and have never been investigated yet, and thus, we reported on the investigation of the biological effects of radiation on HaCat cells and PC12 cells to preliminarily assess the biological safety of the target range of the "SG-III" prototype laser facility. The viability revealed that the damage of cells was dose-dependent. Then we compared the transcriptomes of exposed and unexposed PC12 cells by RNA-Seq analysis based on Illumina Novaseq 6000 platform and found that most significantly differentially expressed genes with corresponding Gene Ontology terms and pathways were strongly involved in proliferation, transformation, necrosis, inflammation response, apoptosis and DNA damage. Furthermore, we find increase in the levels of several proteins responsible for cell-cycle regulation and tumor suppression, suggesting that pathways or mechanisms regarding DNA damage repair was are quickly activated. It was found that "SG-III" prototype radiation could induce DNA damage and promote apoptotic necrosis.

H2O2 enhances the anticancer activity of TMPyP4 by ROS-mediated mitochondrial dysfunction and DNA damage

2021 ◽  
Vol 38 (6) ◽  
Author(s):  
Jianqiang Chen ◽  
Xiangxiang Jin ◽  
Zhe Shen ◽  
Yanan Mei ◽  
Jufan Zhu ◽  
...  
Keyword(s):  
Dna Damage ◽  
Mitochondrial Dysfunction ◽  
Anticancer Activity

scholarly journals In Vivo and In Vitro Assays Evaluating the Biological Activity of Taurine, Glucose and Energetic Beverages

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2198
Author(s):  
Marcos Mateo-Fernández ◽  
Fernando Valenzuela-Gómez ◽  
Rafael Font ◽  
Mercedes Del Río-Celestino ◽  
Tania Merinas-Amo ◽  
...  
Keyword(s):  
Dna Damage ◽  
Drosophila Melanogaster ◽  
Biological Activity ◽  
Biological Effects ◽  
Methylation Status ◽  
Repetitive Sequences ◽  
Energy Drinks ◽  
Red Bull

Taurine is one of the main ingredients used in energy drinks which are highly consumed in adolescents for their sugary taste and stimulating effect. With energy drinks becoming a worldwide phenomenon, the biological effects of these beverages must be evaluated in order to fully comprehend the potential impact of these products on the health due to the fact nutrition is closely related to science since the population consumes food to prevent certain diseases. Therefore, the aim of this study was to evaluate the biological effects of taurine, glucose, classic Red Bull® and sugar-free Red Bull® in order to check the food safety and the nutraceutical potential of these compounds, characterising different endpoints: (i) Toxicology, antitoxicology, genotoxicology and life expectancy assays were performed in the Drosophila melanogaster model organism; (ii) The in vitro chemopreventive activity of testing compounds was determined by assessing their cytotoxicity, the proapoptotic DNA-damage capability to induce internucleosomal fragmentation, the strand breaks activity and the modulator role on the methylation status of genomic repetitive sequences of HL-60 promyelocytic cells. Whereas none tested compounds showed toxic or genotoxic effect, all tested compounds exerted antitoxic and antigenotoxic activity in Drosophila. Glucose, classic Red Bull® and sugar-free Red Bull® were cytotoxic in HL-60 cell line. Classic Red Bull® induced DNA internucleosomal fragmentation although none of them exhibited DNA damage on human leukaemia cells. In conclusion, the tested compounds are safe on Drosophila melanogaster and classic Red Bull® could overall possess nutraceutical potential in the in vivo and in vitro model used in this study. Besides, taurine could holistically be one of the bioactive compounds responsible for the biological activity of classic Red Bull®.

scholarly journals Amphetamines promote mitochondrial dysfunction and DNA damage in pulmonary hypertension

JCI Insight ◽  
2017 ◽  
Vol 2 (2) ◽  
Author(s):  
Pin-I Chen ◽  
Aiqin Cao ◽  
Kazuya Miyagawa ◽  
Nancy F. Tojais ◽  
Jan K. Hennigs ◽  
...  
Keyword(s):  
Dna Damage ◽  
Pulmonary Hypertension ◽  
Mitochondrial Dysfunction

Study of the biological effects and DNA damage exerted by a new dipalladium-Hmtpo complex on human cancer cells

2002 ◽  
Vol 90 (1-2) ◽  
pp. 51-60 ◽  
Author(s):  
Khalid Akdi ◽  
Rosario A. Vilaplana ◽  
Sanaa Kamah ◽  
Jorge A.R. Navarro ◽  
Juan M. Salas ◽  
...  
Keyword(s):  
Dna Damage ◽  
Cancer Cells ◽  
Human Cancer ◽  
Biological Effects ◽  
Human Cancer Cells

scholarly journals Genomic and functional integrity of the hematopoietic system requires tolerance of oxidative DNA lesions

Blood ◽  
2017 ◽  
Vol 130 (13) ◽  
pp. 1523-1534 ◽  
Author(s):  
Ana Martín-Pardillos ◽  
Anastasia Tsaalbi-Shtylik ◽  
Si Chen ◽  
Seka Lazare ◽  
Ronald P. van Os ◽  
...  
Keyword(s):  
Dna Damage ◽  
Mitochondrial Dysfunction ◽  
Replication Stress ◽  
Precursor Cells ◽  
Dna Lesions ◽  
Hematopoietic Stem ◽  
Hematopoietic System ◽  
Functional Integrity ◽  
Key Points

Key Points Tolerance of oxidative DNA lesions ensures the genomic and functional integrity of hematopoietic stem and precursor cells. Endogenous DNA damage–induced replication stress is associated with mitochondrial dysfunction.

scholarly journals Biological Effects of Clustered DNA Damage

2010 ◽  
Vol 45 (2) ◽  
pp. 186-186
Author(s):  
Japan Atomic Energy Agency
Keyword(s):  
Dna Damage ◽  
Biological Effects ◽  
Clustered Dna Damage
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