Age-related changes on MAO in B1/C57 mouse tissues: a quantitative radioautographic study

1994 ◽  
pp. 89-94
Author(s):  
D. J. Saura ◽  
J. G. Richards ◽  
N. Mahy
Keyword(s):  
Age Related ◽  
Mouse Tissues ◽  
Age Related Changes

scholarly journals Multifaceted deregulation of gene expression and protein synthesis with age

2020 ◽  
Vol 117 (27) ◽  
pp. 15581-15590 ◽  
Author(s):  
Aleksandra S. Anisimova ◽  
Mark B. Meerson ◽  
Maxim V. Gerashchenko ◽  
Ivan V. Kulakovskiy ◽  
Sergey E. Dmitriev ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Ribosome Biogenesis ◽  
Cell Function ◽  
Altered Expression ◽  
Biomarkers Of Aging ◽  
Expression Of Genes ◽  
Age Related ◽  
Mouse Tissues ◽  
Terminal Oligopyrimidine ◽  
Age Related Changes

Protein synthesis represents a major metabolic activity of the cell. However, how it is affected by aging and how this in turn impacts cell function remains largely unexplored. To address this question, herein we characterized age-related changes in both the transcriptome and translatome of mouse tissues over the entire life span. We showed that the transcriptome changes govern those in the translatome and are associated with altered expression of genes involved in inflammation, extracellular matrix, and lipid metabolism. We also identified genes that may serve as candidate biomarkers of aging. At the translational level, we uncovered sustained down-regulation of a set of 5′-terminal oligopyrimidine (5′-TOP) transcripts encoding protein synthesis and ribosome biogenesis machinery and regulated by the mTOR pathway. For many of them, ribosome occupancy dropped twofold or even more. Moreover, with age, ribosome coverage gradually decreased in the vicinity of start codons and increased near stop codons, revealing complex age-related changes in the translation process. Taken together, our results reveal systematic and multidimensional deregulation of protein synthesis, showing how this major cellular process declines with age.

scholarly journals Multi-faceted deregulation of gene expression and protein synthesis with age

2020 ◽  
Author(s):  
Aleksandra S. Anisimova ◽  
Mark B. Meerson ◽  
Maxim V. Gerashchenko ◽  
Ivan V. Kulakovskiy ◽  
Sergey E. Dmitriev ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Ribosome Biogenesis ◽  
Cell Function ◽  
Altered Expression ◽  
Biomarkers Of Aging ◽  
Expression Of Genes ◽  
Age Related ◽  
Mouse Tissues ◽  
Terminal Oligopyrimidine ◽  
Age Related Changes

Protein synthesis represents a major metabolic activity of the cell. However, how it is affected by aging and how this in turn impacts cell function remains largely unexplored. To address this question, herein we characterized age-related changes in both the transcriptome and translatome of mouse tissues over the entire lifespan. Expression of the majority of differentially expressed genes followed a U-shaped curve with the turning point around 3-months-old. We showed that transcriptome changes govern changes in the translatome and are associated with altered expression of genes involved in inflammation, extracellular matrix and lipid metabolism. We also identified genes that may serve as candidate biomarkers of aging. At the translational level, we uncovered sustained down-regulation of a set of 5’ terminal oligopyrimidine (5’TOP) transcripts encoding protein synthesis and ribosome biogenesis machinery and regulated by the mTOR pathway. For many of them, ribosome occupancy dropped 3-fold or even more. Moreover, with age, ribosome coverage gradually decreased in the vicinity of start codons and increased near stop codons, revealing complex age-related changes in the translation process. Taken together, our results reveal systematic and multi-dimensional deregulation in protein synthesis, showing how this major cellular process declines with age.

Age-related changes in levels of p66Shc and serine 36-phosphorylated p66Shc in organs and mouse tissues

2009 ◽  
Vol 486 (1) ◽  
pp. 73-80 ◽  
Author(s):  
M. Lebiedzinska ◽  
J. Duszynski ◽  
R. Rizzuto ◽  
P. Pinton ◽  
M.R. Wieckowski
Keyword(s):  
Age Related ◽  
Mouse Tissues ◽  
Age Related Changes

Age-related changes of the 3′APOB-VNTR genotype pool in ageing cohorts

1998 ◽  
Vol 62 (2) ◽  
pp. 115-122 ◽  
Author(s):  
G. De BENEDICTIS ◽  
L. CAROTENUTO ◽  
G. CARRIERI ◽  
M. De LUCA ◽  
E. FALCONE ◽  
...  
Keyword(s):  
Age Related ◽  
Age Related Changes

Age-Related Changes in Flexible Listening: Studies on Meta-Audition and the False Hearing Effect

2012 ◽  
Author(s):  
Chad S. Rogers ◽  
Larry L. Jacoby ◽  
Mitchell S. Sommers ◽  
Arthur Wingfield
Keyword(s):  
Age Related ◽  
Listening Studies ◽  
Age Related Changes
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