Connective tissue ageing: Differences between mouse tissues in age-related changes in collagen extractability

1980 ◽  
Vol 15 (2) ◽  
pp. 113-119 ◽  
Author(s):  
J. David Schofield
Keyword(s):  
Connective Tissue ◽  
Age Related ◽  
Mouse Tissues ◽  
Age Related Changes

Age-related changes and scar formations of perianal connective tissue

1980 ◽  
Vol 23 (3) ◽  
pp. 160-169 ◽  
Author(s):  
Peter A. Haas ◽  
Thomas A. Fox
Keyword(s):  
Connective Tissue ◽  
Age Related ◽  
Age Related Changes

Age-Related Changes in Renal Connective Tissue of Rats

Gerontology ◽  
1969 ◽  
Vol 15 (4-5) ◽  
pp. 252-257 ◽  
Author(s):  
A. Ber ◽  
D. Allalouf ◽  
L. Wasserman ◽  
N. Sharon
Keyword(s):  
Connective Tissue ◽  
Age Related ◽  
Age Related Changes

scholarly journals Multifaceted deregulation of gene expression and protein synthesis with age

2020 ◽  
Vol 117 (27) ◽  
pp. 15581-15590 ◽  
Author(s):  
Aleksandra S. Anisimova ◽  
Mark B. Meerson ◽  
Maxim V. Gerashchenko ◽  
Ivan V. Kulakovskiy ◽  
Sergey E. Dmitriev ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Ribosome Biogenesis ◽  
Cell Function ◽  
Altered Expression ◽  
Biomarkers Of Aging ◽  
Expression Of Genes ◽  
Age Related ◽  
Mouse Tissues ◽  
Terminal Oligopyrimidine ◽  
Age Related Changes

Protein synthesis represents a major metabolic activity of the cell. However, how it is affected by aging and how this in turn impacts cell function remains largely unexplored. To address this question, herein we characterized age-related changes in both the transcriptome and translatome of mouse tissues over the entire life span. We showed that the transcriptome changes govern those in the translatome and are associated with altered expression of genes involved in inflammation, extracellular matrix, and lipid metabolism. We also identified genes that may serve as candidate biomarkers of aging. At the translational level, we uncovered sustained down-regulation of a set of 5′-terminal oligopyrimidine (5′-TOP) transcripts encoding protein synthesis and ribosome biogenesis machinery and regulated by the mTOR pathway. For many of them, ribosome occupancy dropped twofold or even more. Moreover, with age, ribosome coverage gradually decreased in the vicinity of start codons and increased near stop codons, revealing complex age-related changes in the translation process. Taken together, our results reveal systematic and multidimensional deregulation of protein synthesis, showing how this major cellular process declines with age.

scholarly journals Multi-faceted deregulation of gene expression and protein synthesis with age

2020 ◽  
Author(s):  
Aleksandra S. Anisimova ◽  
Mark B. Meerson ◽  
Maxim V. Gerashchenko ◽  
Ivan V. Kulakovskiy ◽  
Sergey E. Dmitriev ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Ribosome Biogenesis ◽  
Cell Function ◽  
Altered Expression ◽  
Biomarkers Of Aging ◽  
Expression Of Genes ◽  
Age Related ◽  
Mouse Tissues ◽  
Terminal Oligopyrimidine ◽  
Age Related Changes

Protein synthesis represents a major metabolic activity of the cell. However, how it is affected by aging and how this in turn impacts cell function remains largely unexplored. To address this question, herein we characterized age-related changes in both the transcriptome and translatome of mouse tissues over the entire lifespan. Expression of the majority of differentially expressed genes followed a U-shaped curve with the turning point around 3-months-old. We showed that transcriptome changes govern changes in the translatome and are associated with altered expression of genes involved in inflammation, extracellular matrix and lipid metabolism. We also identified genes that may serve as candidate biomarkers of aging. At the translational level, we uncovered sustained down-regulation of a set of 5’ terminal oligopyrimidine (5’TOP) transcripts encoding protein synthesis and ribosome biogenesis machinery and regulated by the mTOR pathway. For many of them, ribosome occupancy dropped 3-fold or even more. Moreover, with age, ribosome coverage gradually decreased in the vicinity of start codons and increased near stop codons, revealing complex age-related changes in the translation process. Taken together, our results reveal systematic and multi-dimensional deregulation in protein synthesis, showing how this major cellular process declines with age.

MP-13.06: Are age-related changes in the pelvic connective tissue related to function?

Urology ◽  
2007 ◽  
Vol 70 (3) ◽  
pp. 107
Author(s):  
C. Wallner ◽  
J. Bouma ◽  
N.F. Dabhoiwala ◽  
M.C. DeRuiter ◽  
W.H. Lamers
Keyword(s):  
Connective Tissue ◽  
Age Related ◽  
Age Related Changes

scholarly journals Разработка ЯМР-релаксометра для определения динамики намагниченности протонов воды живых тканей и его использование для оценки возрастных изменений

2019 ◽  
Vol 89 (7) ◽  
pp. 1118
Author(s):  
Ю.И. Неронов ◽  
Д.Д. Косенков
Keyword(s):  
Connective Tissue ◽  
Spin Relaxation ◽  
Recovery Rate ◽  
Relaxation Times ◽  
Paramagnetic Centers ◽  
Metabolic Processes ◽  
Age Related ◽  
The Mean ◽  
Living Tissues ◽  
Age Related Changes

AbstractA desktop NMR relaxometer was created, which allows determining spin–spin relaxation times of water protons in living tissues. Spin relaxation times of protons of water reflect changes in the mean number of paramagnetic centers, since the presence of these centers increases the magnetization recovery rate of water protons in living tissues tens of times. In particular, this method allowed observing age-related changes (sarcopenia) related to substitution of connective tissue for muscle fibers. Relaxometers of this type are comfortable to use and are promising devices for analysis and diagnostics of changes and disorders of metabolic processes.

Age-related changes in levels of p66Shc and serine 36-phosphorylated p66Shc in organs and mouse tissues

2009 ◽  
Vol 486 (1) ◽  
pp. 73-80 ◽  
Author(s):  
M. Lebiedzinska ◽  
J. Duszynski ◽  
R. Rizzuto ◽  
P. Pinton ◽  
M.R. Wieckowski
Keyword(s):  
Age Related ◽  
Mouse Tissues ◽  
Age Related Changes
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