A rat model of the 131I-induced changes in thyroid function

1986 ◽  
Vol 9 (5) ◽  
pp. 367-370 ◽  
Author(s):  
C. P. Reilly ◽  
R. G. Symons ◽  
M. L. Wellby
Keyword(s):  
Thyroid Function ◽  
Rat Model ◽  
Induced Changes

scholarly journals Respiratory exposure to single-walled carbon nanotubes induced changes in vascular homeostasis and the expression of peripheral blood related genes in a rat model

2015 ◽  
Vol 4 (5) ◽  
pp. 1225-1237 ◽  
Author(s):  
Jun Yan ◽  
Zhiqing Lin ◽  
Bencheng Lin ◽  
Honglian Yang ◽  
Wei Zhang ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Rat Model ◽  
Peripheral Blood ◽  
Single Walled Carbon Nanotubes ◽  
Epidemiological Studies ◽  
Vascular Homeostasis ◽  
Single Walled Carbon ◽  
Respiratory Exposure ◽  
Induced Changes ◽  
Walled Carbon Nanotubes

Epidemiological studies have demonstrated that nanometre particles in polluted air can increase the risk of CVD, which is dangerous to mankind.

Altitude-induced changes in plasma thyroxine, 3,5,3'-triiodothyronine, and thyrotropin in rats

1982 ◽  
Vol 53 (2) ◽  
pp. 313-315 ◽  
Author(s):  
J. M. Connors ◽  
L. G. Martin
Keyword(s):  
High Altitude ◽  
Thyroid Function ◽  
Plasma Concentrations ◽  
Thyroid Tissue ◽  
Severe Hypoxia ◽  
Elevated Plasma ◽  
Altitude Exposure ◽  
Thyroid Secretion ◽  
Induced Changes ◽  
Tsh Levels

We have studied the thyroid function of high-altitude-acclimated (6,900 m for 5 wk) and nonaltitude-acclimated control (198 m) rats. After 5 wk of high-altitude exposure the plasma concentrations of both thyroxine (T4) and triiodothyronine (T3) were lower than those in control rats (4.7 +/- 0.3 vs. 3.3 +/- 0.2 microgram/dl and 96 +/- 5 vs. 74 +/- 6 ng/dl, respectively). The plasma thyrotropin (TSH) concentration was elevated in the high-altitude-acclimated rats compared with controls (52 +/- 4 vs. 29 +/- 3 micrograms/dl, respectively). Gross anatomical (thyroid wt/body wt) and histological observations of thyroid tissue were consistent with elevated plasma TSH concentrations. These results suggest that the fall in the plasma concentrations of T4 and T3 during acclimation to severe hypoxia is due to a primary block of thyroid secretion and not to a fall in plasma TSH levels.

scholarly journals Effects of bone marrow cell transplant on thyroid function in an I131-induced low T4 and elevated TSH rat model

2007 ◽  
Vol 6 (1) ◽  
Author(s):  
Gustavo E Guajardo-Salinas ◽  
Juan A Carvajal ◽  
Ángel A Gaytan-Ramos ◽  
Luis Arroyo ◽  
Alberto G López-Reyes ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Thyroid Function ◽  
Bone Marrow Cell ◽  
Rat Model ◽  
Marrow Cell ◽  
Cell Transplant

scholarly journals Vitamin D3 Treatment Alters Thyroid Functional Morphology in Orchidectomized Rat Model of Osteoporosis

2022 ◽  
Vol 23 (2) ◽  
pp. 791
Author(s):  
Branka Šošić-Jurjević ◽  
Svetlana Trifunović ◽  
Jasmina Živanović ◽  
Vladimir Ajdžanović ◽  
Marko Miler ◽  
...  
Keyword(s):  
Vitamin D ◽  
Thyroid Hormones ◽  
Functional Morphology ◽  
Rat Model ◽  
Cell Subpopulation ◽  
Treatment Of Osteoporosis ◽  
Hormone Synthesis ◽  
Fine Regulation ◽  
Induced Changes ◽  
Group Concentration

Vitamin D plays an essential role in prevention and treatment of osteoporosis. Thyroid hormones, in addition to vitamin D, significantly contribute to regulation of bone remodeling cycle and health. There is currently no data about a possible connection between vitamin D treatment and the thyroid in the context of osteoporosis. Middle-aged Wistar rats were divided into: sham operated (SO), orchidectomized (Orx), and cholecalciferol-treated orchidectomized (Orx + Vit. D3; 5 µg/kg b.m./day during three weeks) groups (n = 6/group). Concentration of 25(OH)D in serum of the Orx + Vit. D3 group increased 4 and 3.2 times (p < 0.0001) respectively, compared to Orx and SO group. T4, TSH, and calcitonin in serum remained unaltered. Vit. D3 treatment induced changes in thyroid functional morphology that indicate increased utilization of stored colloid and release of thyroid hormones in comparison with hormone synthesis, to maintain hormonal balance. Increased expression of nuclear VDR (p < 0.05) points to direct, TSH independent action of Vit. D on thyrocytes. Strong CYP24A1 immunostaining in C cells suggests its prominent expression in response to Vit. D in this cell subpopulation in orchidectomized rat model of osteoporosis. The indirect effect of Vit. D on bone, through fine regulation of thyroid function, is small.

scholarly journals Salt-Induced Changes in Cardiac Phosphoproteome in a Rat Model of Chronic Renal Failure

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e100331 ◽  
Author(s):  
Zhengxiu Su ◽  
Hongguo Zhu ◽  
Menghuan Zhang ◽  
Liangliang Wang ◽  
Hanchang He ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Rat Model ◽  
Induced Changes

A rat model of childhood diet-induced obesity: Roux-en-Y gastric bypass induced changes in metabolic parameters and gastric peptide ghrelin

2007 ◽  
Vol 23 (7) ◽  
pp. 653-657 ◽  
Author(s):  
Charles J. Aprahamian ◽  
Gonça Tekant ◽  
Min Chen ◽  
Ayden Yagmurlu ◽  
Ying-kui Yang ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Rat Model ◽  
Metabolic Parameters ◽  
Diet Induced Obesity ◽  
Childhood Diet ◽  
Induced Changes
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