scholarly journals Vitamin D3 Treatment Alters Thyroid Functional Morphology in Orchidectomized Rat Model of Osteoporosis

2022 ◽  
Vol 23 (2) ◽  
pp. 791
Author(s):  
Branka Šošić-Jurjević ◽  
Svetlana Trifunović ◽  
Jasmina Živanović ◽  
Vladimir Ajdžanović ◽  
Marko Miler ◽  
...  
Keyword(s):  
Vitamin D ◽  
Thyroid Hormones ◽  
Functional Morphology ◽  
Rat Model ◽  
Cell Subpopulation ◽  
Treatment Of Osteoporosis ◽  
Hormone Synthesis ◽  
Fine Regulation ◽  
Induced Changes ◽  
Group Concentration

Vitamin D plays an essential role in prevention and treatment of osteoporosis. Thyroid hormones, in addition to vitamin D, significantly contribute to regulation of bone remodeling cycle and health. There is currently no data about a possible connection between vitamin D treatment and the thyroid in the context of osteoporosis. Middle-aged Wistar rats were divided into: sham operated (SO), orchidectomized (Orx), and cholecalciferol-treated orchidectomized (Orx + Vit. D3; 5 µg/kg b.m./day during three weeks) groups (n = 6/group). Concentration of 25(OH)D in serum of the Orx + Vit. D3 group increased 4 and 3.2 times (p < 0.0001) respectively, compared to Orx and SO group. T4, TSH, and calcitonin in serum remained unaltered. Vit. D3 treatment induced changes in thyroid functional morphology that indicate increased utilization of stored colloid and release of thyroid hormones in comparison with hormone synthesis, to maintain hormonal balance. Increased expression of nuclear VDR (p < 0.05) points to direct, TSH independent action of Vit. D on thyrocytes. Strong CYP24A1 immunostaining in C cells suggests its prominent expression in response to Vit. D in this cell subpopulation in orchidectomized rat model of osteoporosis. The indirect effect of Vit. D on bone, through fine regulation of thyroid function, is small.

Haemodialysis-induced changes in thyroid hormones and thyrotropin

2013 ◽  
Author(s):  
Jiri Horacek ◽  
Sylvie Dusilova Sulkova ◽  
Eva Malirova ◽  
Blanka Dlabalova ◽  
Roman Safranek ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Induced Changes

A rat model of the 131I-induced changes in thyroid function

1986 ◽  
Vol 9 (5) ◽  
pp. 367-370 ◽  
Author(s):  
C. P. Reilly ◽  
R. G. Symons ◽  
M. L. Wellby
Keyword(s):  
Thyroid Function ◽  
Rat Model ◽  
Induced Changes

Iodide Metabolism and Effects

2020 ◽  
pp. 25-33
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Gland ◽  
Thyroid Hormones ◽  
Dietary Supplement ◽  
Thyroid Function ◽  
Thyroid Stimulating Hormone ◽  
Hormone Synthesis ◽  
Serum Tsh ◽  
Tsh Stimulation ◽  
Sensitive Marker

Iodine (I2) is essential in the synthesis of thyroid hormones T4 and T3 and functioning of the thyroid gland. Both T3 and T4 are metabolically active, but T3 is four times more potent than T4. Our body contains 20-30 mg of I2, which is mainly stored in the thyroid gland. Iodine is naturally present in some foods, added to others, and available as a dietary supplement. Serum thyroid stimulating hormone (TSH) level is a sensitive marker of thyroid function. Serum TSH is increased in hypothyroidism as in Hashimoto's thyroiditis. In addition to regulation of thyroid function, TSH promotes thyroid growth. If thyroid hormone synthesis is chronically impaired, TSH stimulation eventually may lead to the development of a goiter. This chapter explores the iodide metabolism and effects of Hashimoto's disease.

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