Synthesis and antihypertensive activity evaluation in spontaneously hypertensive rats of nitrendipine analogues

2010 ◽  
Vol 20 (8) ◽  
pp. 1325-1330 ◽  
Author(s):  
Kai Zhou ◽  
Xiao-meng Wang ◽  
Yi-zhi Zhao ◽  
Yong-xiao Cao ◽  
Qiang Fu ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Antihypertensive Activity ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Activity Evaluation

scholarly journals Isolasi, Komponen Peptida Bioaktif yang Terkandung Dalam Kasein Susu

2000 ◽  
Vol 1 (1) ◽  
pp. 32-39
Author(s):  
Helmi M. Yahya ◽  
Amhar Abubakar
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Antihypertensive Effect ◽  
Casein Hydrolysate ◽  
Amino Acid Sequences ◽  
Lactobacillus Helveticus ◽  
Antihypertensive Activity ◽  
Hypertensive Rats ◽  
Extracellular Proteinase ◽  
Reverse Phase ◽  
Spontaneously Hypertensive

ABSTRACT. The production of Casein hydrolysate with an extracellular proteinase from Lactobacillus helveticus CP790, was fractionated by two-step reverse phase heigh performance liquid chromatography. Only 1 fraction showed antihypertensive activity as measured by systolic blood pressure in spontaneously hypertensive rats after oral adsministration. Ten peptides in the fraction were further purified and identified by analisys of amino acid sequences. Each identified peptide was chemically synthesized, and the ant.ihypertensive activity of each peptide was evaluated in spontaneously hypertensive rats. The synthetic peptide with a sequence of Lys-Val-Leu-Pro-Val-Pro-Gln, found in β-casein, indicated strong antihypertensive activity from 2 to 10 h after oral adsministration of 2 mg of peptide/kg of BW, and the effect was maximal at 6 h after oral adsministration. Moreover, the antihypertensive effect of the peptide was dependent on the dosage of peptide from 0.5 to 2 mg o peptide/kg of BW.

Antihypertensive activity of AMC3, an engineered 11S amaranth globulin expressed in Escherichia coli, in spontaneously hypertensive rats

2013 ◽  
Vol 5 (3) ◽  
pp. 1441-1449 ◽  
Author(s):  
Sergio Medina-Godoy ◽  
Silvia K. Rodríguez-Yáñez ◽  
Norma A. Bobadilla ◽  
Rosalba Pérez-Villalva ◽  
Rafael Valdez-Ortiz ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Spontaneously Hypertensive Rats ◽  
Antihypertensive Activity ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

scholarly journals Antihypertensive Activity of Eucommia Ulmoides Oliv: Male Flower Extract in Spontaneously Hypertensive Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-6 ◽  
Author(s):  
Zhen-Jiang Ding ◽  
Chao Liang ◽  
Xiao Wang ◽  
Xin Yao ◽  
Ruo-Han Yang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Aqueous Extract ◽  
Spontaneously Hypertensive Rats ◽  
Male Flower ◽  
Antihypertensive Activity ◽  
Eucommia Ulmoides ◽  
Ang Ii ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Male Flowers

Eucommia ulmoides Oliv. is a traditional medical plant in Asia; however, it is still unknown whether Eucommia male flowers have an antihypertensive activity. In this study, we found that the aqueous extract of Eucommia ulmoides Oliv. male flowers can lower the blood pressure of SHR in a dose-dependent manner. Mechanistic studies suggested that the aqueous extract of male flowers can promote the mRNA and protein expressions of ACE2 in the kidney of SHR. ELISA assay showed that the plasma levels of ANG II was decreased, while ANG-(1–7) was increased in SHR treated with the aqueous extract of male flowers. ACE2 inhibitor DX600 can reverse the aqueous extract of Eucommia ulmoides Oliv. male flower-induced downregulation of Ang II and upregulation of Ang-(1–7), as well as the reduction of blood pressure in SHR. Moreover, Ang-(1–7)-Mas receptor antagonist A-779 abolished the antihypertensive effects of the aqueous extract of Eucommia ulmoides Oliv. male flower in SHR. The aqueous extract of Eucommia ulmoides Oliv. male flowers exhibited an antihypertensive action through the activation of ACE2-Ang-(1–7)-Mas signaling pathways in spontaneously hypertensive rats.

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