Antihypertensive Activity of the Aqueous Extract ofRetama raetamForssk. Leaves in Spontaneously Hypertensive Rats

2008 ◽  
Vol 7 (2) ◽  
pp. 65-77 ◽  
Author(s):  
M. Eddouks ◽  
M. Maghrani ◽  
L. Louedec ◽  
M. Haloui ◽  
J. B. Michel
Keyword(s):  
Aqueous Extract ◽  
Spontaneously Hypertensive Rats ◽  
Antihypertensive Activity ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

scholarly journals Antihypertensive Activity of Eucommia Ulmoides Oliv: Male Flower Extract in Spontaneously Hypertensive Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-6 ◽  
Author(s):  
Zhen-Jiang Ding ◽  
Chao Liang ◽  
Xiao Wang ◽  
Xin Yao ◽  
Ruo-Han Yang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Aqueous Extract ◽  
Spontaneously Hypertensive Rats ◽  
Male Flower ◽  
Antihypertensive Activity ◽  
Eucommia Ulmoides ◽  
Ang Ii ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Male Flowers

Eucommia ulmoides Oliv. is a traditional medical plant in Asia; however, it is still unknown whether Eucommia male flowers have an antihypertensive activity. In this study, we found that the aqueous extract of Eucommia ulmoides Oliv. male flowers can lower the blood pressure of SHR in a dose-dependent manner. Mechanistic studies suggested that the aqueous extract of male flowers can promote the mRNA and protein expressions of ACE2 in the kidney of SHR. ELISA assay showed that the plasma levels of ANG II was decreased, while ANG-(1–7) was increased in SHR treated with the aqueous extract of male flowers. ACE2 inhibitor DX600 can reverse the aqueous extract of Eucommia ulmoides Oliv. male flower-induced downregulation of Ang II and upregulation of Ang-(1–7), as well as the reduction of blood pressure in SHR. Moreover, Ang-(1–7)-Mas receptor antagonist A-779 abolished the antihypertensive effects of the aqueous extract of Eucommia ulmoides Oliv. male flower in SHR. The aqueous extract of Eucommia ulmoides Oliv. male flowers exhibited an antihypertensive action through the activation of ACE2-Ang-(1–7)-Mas signaling pathways in spontaneously hypertensive rats.

scholarly journals Piper sarmentosum Leaves Aqueous Extract Attenuates Vascular Endothelial Dysfunction in Spontaneously Hypertensive Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Fatimatuzzahra Hashim Fauzy ◽  
Maizura Mohd Zainudin ◽  
Hidayatul Radziah Ismawi ◽  
Taher F. T. Elshami
Keyword(s):  
Blood Pressure ◽  
Aqueous Extract ◽  
Spontaneously Hypertensive Rats ◽  
Positive Control ◽  
No Production ◽  
Hypertensive Rats ◽  
Traditional Use ◽  
Spontaneously Hypertensive ◽  
Treatment Groups ◽  
Endothelin System

Piper sarmentosum is a tropical plant in Southeast Asia known for its traditional use in curing various ailments including hypertension. Previous research works have provided evidence for the herb’s antihypertensive property. However, the exact mechanisms involved are still in question. The present study investigated the effects of Piper sarmentosum leaves aqueous extract (PSAE) treatment on vascular endothelin system in spontaneously hypertensive rats (SHRs). Four groups of SHRs were treated for 28 consecutive days, with negative and positive control groups receiving distilled water and 3 mg/kg perindopril, respectively. Another two groups are the treatment groups, which received PSAE and combination of 1.5 mg/kg perindopril and PSAE. Weekly measurements of blood pressure showed that PSAE significantly reduced the systolic, diastolic, and mean arterial pressures (P<0.05) of the rats. PSAE also increased mesenteric artery nitric oxide (NO) level (P<0.05) and reduced endothelin-1 (ET-1) level (P<0.05) in the treatment groups. Our results demonstrate that oral administration of PSAE reduced blood pressure in SHRs by reducing the ET-1 level while increasing NO production.

scholarly journals Isolasi, Komponen Peptida Bioaktif yang Terkandung Dalam Kasein Susu

2000 ◽  
Vol 1 (1) ◽  
pp. 32-39
Author(s):  
Helmi M. Yahya ◽  
Amhar Abubakar
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Antihypertensive Effect ◽  
Casein Hydrolysate ◽  
Amino Acid Sequences ◽  
Lactobacillus Helveticus ◽  
Antihypertensive Activity ◽  
Hypertensive Rats ◽  
Extracellular Proteinase ◽  
Reverse Phase ◽  
Spontaneously Hypertensive

ABSTRACT. The production of Casein hydrolysate with an extracellular proteinase from Lactobacillus helveticus CP790, was fractionated by two-step reverse phase heigh performance liquid chromatography. Only 1 fraction showed antihypertensive activity as measured by systolic blood pressure in spontaneously hypertensive rats after oral adsministration. Ten peptides in the fraction were further purified and identified by analisys of amino acid sequences. Each identified peptide was chemically synthesized, and the ant.ihypertensive activity of each peptide was evaluated in spontaneously hypertensive rats. The synthetic peptide with a sequence of Lys-Val-Leu-Pro-Val-Pro-Gln, found in β-casein, indicated strong antihypertensive activity from 2 to 10 h after oral adsministration of 2 mg of peptide/kg of BW, and the effect was maximal at 6 h after oral adsministration. Moreover, the antihypertensive effect of the peptide was dependent on the dosage of peptide from 0.5 to 2 mg o peptide/kg of BW.

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