Effect of thiol redox state modulators on oxidative stress and sclerotial differentiation of the phytopathogenic fungus Rhizoctonia solani

2007 ◽  
Vol 188 (3) ◽  
pp. 225-233 ◽  
Author(s):  
Nikolaos Patsoukis ◽  
Christos D. Georgiou
Keyword(s):  
Oxidative Stress ◽  
Rhizoctonia Solani ◽  
Redox State ◽  
Phytopathogenic Fungus ◽  
Thiol Redox State ◽  
Thiol Redox ◽  
Sclerotial Differentiation

Differentiation of Sclerotinia minor depends on thiol redox state and oxidative stress

2008 ◽  
Vol 54 (1) ◽  
pp. 28-36 ◽  
Author(s):  
Nikolaos Patsoukis ◽  
Christos D. Georgiou
Keyword(s):  
Oxidative Stress ◽  
Redox State ◽  
Phytopathogenic Fungus ◽  
Sclerotinia Minor ◽  
Thiol Redox State ◽  
Sh Group ◽  
Thiol Redox ◽  
Sclerotial Differentiation ◽  
And Oxidative Stress

Sclerotial differentiation in Sclerotinia minor is associated with oxidative stress and thiol redox state. The significance of oxidative stress to sclerotial differentiation was revealed by the higher oxidative stress of S. minor compared with a nonsclerotiogenic counterpart. The effect of thiol redox state on sclerotial differentiation was shown by the antioxidant action of the thiol (-SH) group of N-acetylcysteine and cysteine and by an unknown (not antioxidant) role of glutathione (GSH) on S. minor. The nonantioxidant role of GSH was indicated by the differentiation-inhibiting and differentiation-noninhibiting actions of the GSH biosynthesis inhibitor l-buthionine-S,R-sulfoximine and the GSH biosynthesis inducer l-2-oxo-thiazolidine-4-carboxylate, respectively, and by the increase of oxidative stress they caused during the transition from the undifferentiated to differentiated state of S. minor. Moreover, N-acetylcysteine can be used as a potent nontoxic fungicide against this phytopathogenic fungus by acting as a growth-inhibiting cytotoxic oxidant and by sustaining the fungus in the undifferentiated hyphal stage, which is vulnerable to degradation by soil microorganisms.

Thiol redox state and oxidative stress in midbrain and striatum of weaver mutant mice, a genetic model of nigrostriatal dopamine deficiency

2005 ◽  
Vol 376 (1) ◽  
pp. 24-28 ◽  
Author(s):  
Nikolaos Patsoukis ◽  
Ioannis Papapostolou ◽  
George Zervoudakis ◽  
Christos D. Georgiou ◽  
Nikolaos A. Matsokis ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Redox State ◽  
Genetic Model ◽  
Mutant Mice ◽  
Thiol Redox State ◽  
Nigrostriatal Dopamine ◽  
Thiol Redox ◽  
And Oxidative Stress

Thiol redox state (TRS) and oxidative stress in the mouse hippocampus after pentylenetetrazol-induced epileptic seizure

2004 ◽  
Vol 357 (2) ◽  
pp. 83-86 ◽  
Author(s):  
Nikolaos Patsoukis ◽  
George Zervoudakis ◽  
Nikolaos T Panagopoulos ◽  
Christos D Georgiou ◽  
Fevronia Angelatou ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Epileptic Seizure ◽  
Redox State ◽  
Thiol Redox State ◽  
Mouse Hippocampus ◽  
Thiol Redox ◽  
And Oxidative Stress

scholarly journals The thiol redox state of lymphoid organs is modified by immunization: Role of different immune cell populations

2008 ◽  
Vol 38 (9) ◽  
pp. 2419-2425 ◽  
Author(s):  
Patrizia Castellani ◽  
Giovanna Angelini ◽  
Laura Delfino ◽  
Andrea Matucci ◽  
Anna Rubartelli
Keyword(s):  
Redox State ◽  
Immune Cell ◽  
Lymphoid Organs ◽  
Cell Populations ◽  
Thiol Redox State ◽  
Thiol Redox

scholarly journals The Effectiveness of Glutathione Redox Status as a Possible Tumor Marker in Colorectal Cancer

2021 ◽  
Vol 22 (12) ◽  
pp. 6183
Author(s):  
Delia Acevedo-León ◽  
Lidia Monzó-Beltrán ◽  
Segundo Ángel Gómez-Abril ◽  
Nuria Estañ-Capell ◽  
Natalia Camarasa-Lillo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Redox State ◽  
Reduced Glutathione ◽  
Redox Status ◽  
Oxidation Products ◽  
Interventional Study ◽  
Thiol Redox State ◽  
Thiol Redox ◽  
Glutathione Redox

The role of oxidative stress (OS) in cancer is a matter of great interest due to the implication of reactive oxygen species (ROS) and their oxidation products in the initiation of tumorigenesis, its progression, and metastatic dissemination. Great efforts have been made to identify the mechanisms of ROS-induced carcinogenesis; however, the validation of OS byproducts as potential tumor markers (TMs) remains to be established. This interventional study included a total of 80 colorectal cancer (CRC) patients and 60 controls. By measuring reduced glutathione (GSH), its oxidized form (GSSG), and the glutathione redox state in terms of the GSSG/GSH ratio in the serum of CRC patients, we identified significant changes as compared to healthy subjects. These findings are compatible with the effectiveness of glutathione as a TM. The thiol redox state showed a significant increase towards oxidation in the CRC group and correlated significantly with both the tumor state and the clinical evolution. The sensitivity and specificity of serum glutathione levels are far above those of the classical TMs CEA and CA19.9. We conclude that the GSSG/GSH ratio is a simple assay which could be validated as a novel clinical TM for the diagnosis and monitoring of CRC.

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