Hippocampal network oscillations at the interplay between innate anxiety and learned fear

2018 ◽  
Vol 236 (1) ◽  
pp. 321-338 ◽  
Author(s):  
Gürsel Çalışkan ◽  
Oliver Stork
Keyword(s):  
Network Oscillations ◽  
Hippocampal Network ◽  
Learned Fear ◽  
Innate Anxiety

Nonspecific effects of the gap junction blocker mefloquine on fast hippocampal network oscillations in the adult rat in vitro

Neuroscience ◽  
2011 ◽  
Vol 192 ◽  
pp. 11-19 ◽  
Author(s):  
C.J. Behrens ◽  
R. ul Haq ◽  
A. Liotta ◽  
M.L. Anderson ◽  
U. Heinemann
Keyword(s):  
Gap Junction ◽  
Adult Rat ◽  
Network Oscillations ◽  
Nonspecific Effects ◽  
Hippocampal Network

Generation of Slow Network Oscillations in the Developing Rat Hippocampus After Blockade of Glutamate Uptake

2007 ◽  
Vol 98 (4) ◽  
pp. 2324-2336 ◽  
Author(s):  
Adriano Augusto Cattani ◽  
Valérie Delphine Bonfardin ◽  
Alfonso Represa ◽  
Yehezkel Ben-Ari ◽  
Laurent Aniksztejn
Keyword(s):  
Nmda Receptors ◽  
Glutamate Uptake ◽  
Pyramidal Cells ◽  
Cell Types ◽  
Proper Function ◽  
Network Oscillations ◽  
Bath Application ◽  
Hippocampal Network

Cell-surface glutamate transporters are essential for the proper function of early cortical networks because their dysfunction induces seizures in the newborn rat in vivo. We have now analyzed the consequences of their inhibition by dl-TBOA on the activity of the developing CA1 rat hippocampal network in vitro. dl-TBOA generated a pattern of recurrent depolarization with an onset and decay of several seconds' duration in interneurons and pyramidal cells. These slow network oscillations (SNOs) were mostly mediated by γ-aminobutyric acid (GABA) in pyramidal cells and by GABA and N-methyl-d-aspartate (NMDA) receptors in interneurons. However, in both cell types SNOs were blocked by NMDA receptor antagonists, suggesting that their generation requires a glutamatergic drive. Moreover, in interneurons, SNOs were still generated after the blockade of NMDA-mediated synaptic currents with MK-801, suggesting that SNOs are expressed by the activation of extrasynaptic NMDA receptors. Long-lasting bath application of glutamate or NMDA failed to induce SNOs, indicating that they are generated by periodic but not sustained activation of NMDA receptors. In addition, SNOs were observed in interneurons recorded in slices with or without the strata pyramidale and oriens, suggesting that the glutamatergic drive may originate from the radiatum and pyramidale strata. We propose that in the absence of an efficient transport of glutamate, the transmitter diffuses in the extracellular space to activate extrasynaptic NMDA receptors preferentially present on interneurons that in turn activate other interneurons and pyramidal cells. This periodic neuronal coactivation may contribute to the generation of seizures when glutamate transport dysfunction is present.

scholarly journals Hippocampal Network Oscillations in APP/APLP2-Deficient Mice

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e61198 ◽  
Author(s):  
Xiaomin Zhang ◽  
Ulrike Herrmann ◽  
Sascha W. Weyer ◽  
Martin Both ◽  
Ulrike C. Müller ◽  
...  
Keyword(s):  
Network Oscillations ◽  
Hippocampal Network ◽  
Deficient Mice

scholarly journals Erratum: Corrigendum: Spike timing of dendrite-targeting bistratified cells during hippocampal network oscillations in vivo

2006 ◽  
Vol 9 (7) ◽  
pp. 979-979
Author(s):  
Thomas Klausberger ◽  
László Márton ◽  
Agnes Baude ◽  
J David B Roberts ◽  
Peter J Magill ◽  
...  
Keyword(s):  
Spike Timing ◽  
Network Oscillations ◽  
Hippocampal Network

scholarly journals Prefrontal entrainment of amygdala activity signals safety in learned fear and innate anxiety

2013 ◽  
Vol 17 (1) ◽  
pp. 106-113 ◽  
Author(s):  
Ekaterina Likhtik ◽  
Joseph M Stujenske ◽  
Mihir A Topiwala ◽  
Alexander Z Harris ◽  
Joshua A Gordon
Keyword(s):  
Amygdala Activity ◽  
Learned Fear ◽  
Innate Anxiety
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