Isoforms of the nonclassical class I MHC antigen H2-Q5 are enriched in brain and encode Qdm peptide

2010 ◽  
Vol 63 (1) ◽  
pp. 57-64 ◽  
Author(s):  
Nora E. Renthal ◽  
Paula A. Guidry ◽  
Sharmila Shanmuganad ◽  
William Renthal ◽  
Iwona Stroynowski
Keyword(s):  
Class I ◽  
Class I Mhc ◽  
Mhc Antigen ◽  
Nonclassical Class

Class I MHC Antigen Processing

2006 ◽  
pp. 1-30
Author(s):  
Peter J. Miller ◽  
Edward J. Collins
Keyword(s):  
Antigen Processing ◽  
Class I ◽  
Class I Mhc ◽  
Mhc Antigen

Role of Class-II Major Histocompatibility Complex (MHC)-Antigen–Positive Donor Leukocytes in Transfusion-Induced Alloimmunization to Donor Class-I MHC Antigens

Blood ◽  
1998 ◽  
Vol 92 (2) ◽  
pp. 690-694
Author(s):  
K.J. Kao ◽  
M.L.U. del Rosario
Keyword(s):  
Immune Response ◽  
Peripheral Blood ◽  
Class Ii ◽  
Class I ◽  
Mononuclear Leukocytes ◽  
Class I Mhc ◽  
Mhc Antigens ◽  
Mhc Molecules ◽  
Class Ii Mhc ◽  
Mhc Antigen

It has been shown that peripheral-blood mononuclear leukocytes (MNL) are responsible for transfusion-induced alloimmunization to donor major histocompatability complex (MHC) antigens. However, it is not known which subset of MNL is responsible for this immune response. Because elimination of class-II MHC antigen-positive passenger leukocytes effectively prolongs the survival of allografts, it has been hypothesized that class-II positive MNL are responsible for immunizing transfusion recipients to donor MHC antigens. To test this hypothesis, two different approaches were used. First, we compared the alloantigenicity of BALB/c mice (H-2d) peripheral blood MNL before and after depletion of class-II positive cells. CBA mice (H-2k) were used as transfusion recipients. Antibody development to donor class-I H-2 antigens was determined by flow cytometry and enzyme-linked immunoassay. After four weekly transfusions of MNL depleted for class-II positive cells, only 25% of recipient mice developed antibodies to donor H-2d antigens. In contrast, all mice transfused with control MNL became immunized. Second, we studied the alloantigenicity of peripheral MNL from C57BL/6 mice (H-2b) with homozygous deficiency of class-II MHC molecules in H-2 disparate recipient mice. After transfusions with class-II MHC molecule-deficient MNL, 0% of BALB/c, 40% of C57BR, and 25% of CBA-recipient mice developed antibodies to donor H-2b antigen. All control recipient mice were immunized. The antibody activities of the controls were also higher than those in the treatment group who became immunized. Thus, our study shows that class-II MHC antigen-positive MNL play a significant role in transfusion-induced alloimmunization to donor class-I MHC antigens. The results also support the hypothesis that direct antigen presentation by donor class-II positive MNL to the immune system of transfusion recipients is critical for the initiation of humoral immune response to donor MHC antigens.

Induction of Tolerance Toward Rat Cardiac Allografts by Treatment With Allochimeric Class I MHC Antigen And FTY7201

1997 ◽  
Vol 64 (10) ◽  
pp. 1407-1414 ◽  
Author(s):  
Shih-Chieh Chueh ◽  
Ling Tian ◽  
Min Wang ◽  
Mou-Er Wang ◽  
Stanislaw M. Stepkowski ◽  
...  
Keyword(s):  
Class I ◽  
Class I Mhc ◽  
Cardiac Allografts ◽  
Mhc Antigen ◽  
Induction Of Tolerance

scholarly journals Depletion of CD8+ cells in human thymic medulla results in selective immune deficiency.

1989 ◽  
Vol 170 (6) ◽  
pp. 2177-2182 ◽  
Author(s):  
C M Roifman ◽  
D Hummel ◽  
H Martinez-Valdez ◽  
P Thorner ◽  
P J Doherty ◽  
...  
Keyword(s):  
T Cells ◽  
Peripheral Blood ◽  
Inbred Mice ◽  
Pneumocystis Carinii ◽  
Antigen Expression ◽  
Class I ◽  
Class I Mhc ◽  
Cd8 Cells ◽  
Mhc Antigen ◽  
Selection Of

CD8 molecules expressed on the surface of a subset of T cells participate in the selection of class I MHC antigen-restricted T cells in the thymus, and in MHC-restricted immune responses of mature class I MHC antigen-restricted T cells. Here we describe an immune-deficient patient with lack of CD8+ peripheral blood cells. The patient presented with Pneumocystis carinii pneumonia and was unable to reject an allogeneic skin graft, but had normal primary and secondary antibody responses. Examination of the patient's thymus revealed that the loss of CD8+ cells occurred during intrathymic differentiation: the patient's immature cortical thymocytes included both CD4+ and CD8+ cells while the mature medullary cells expressed the CD4 but not the CD8 protein on their surface. Northern blot and polymerase chain reaction analyses revealed the presence of CD8 alpha and beta mRNA in the patient's thymus but not in the peripheral blood. Both class I MHC antigen expression and the expressed TCR V beta repertoire are normal in this patient. These data are consistent with an impaired selection of CD8+ cells in the patient's thymus and support the role of the CD8 surface protein in thymic selection previously characterized in genetically manipulated and inbred mice.

Role of Class-II Major Histocompatibility Complex (MHC)-Antigen–Positive Donor Leukocytes in Transfusion-Induced Alloimmunization to Donor Class-I MHC Antigens

Blood ◽  
1998 ◽  
Vol 92 (2) ◽  
pp. 690-694 ◽  
Author(s):  
K.J. Kao ◽  
M.L.U. del Rosario
Keyword(s):  
Immune Response ◽  
Peripheral Blood ◽  
Class Ii ◽  
Class I ◽  
Mononuclear Leukocytes ◽  
Class I Mhc ◽  
Mhc Antigens ◽  
Mhc Molecules ◽  
Class Ii Mhc ◽  
Mhc Antigen

Abstract It has been shown that peripheral-blood mononuclear leukocytes (MNL) are responsible for transfusion-induced alloimmunization to donor major histocompatability complex (MHC) antigens. However, it is not known which subset of MNL is responsible for this immune response. Because elimination of class-II MHC antigen-positive passenger leukocytes effectively prolongs the survival of allografts, it has been hypothesized that class-II positive MNL are responsible for immunizing transfusion recipients to donor MHC antigens. To test this hypothesis, two different approaches were used. First, we compared the alloantigenicity of BALB/c mice (H-2d) peripheral blood MNL before and after depletion of class-II positive cells. CBA mice (H-2k) were used as transfusion recipients. Antibody development to donor class-I H-2 antigens was determined by flow cytometry and enzyme-linked immunoassay. After four weekly transfusions of MNL depleted for class-II positive cells, only 25% of recipient mice developed antibodies to donor H-2d antigens. In contrast, all mice transfused with control MNL became immunized. Second, we studied the alloantigenicity of peripheral MNL from C57BL/6 mice (H-2b) with homozygous deficiency of class-II MHC molecules in H-2 disparate recipient mice. After transfusions with class-II MHC molecule-deficient MNL, 0% of BALB/c, 40% of C57BR, and 25% of CBA-recipient mice developed antibodies to donor H-2b antigen. All control recipient mice were immunized. The antibody activities of the controls were also higher than those in the treatment group who became immunized. Thus, our study shows that class-II MHC antigen-positive MNL play a significant role in transfusion-induced alloimmunization to donor class-I MHC antigens. The results also support the hypothesis that direct antigen presentation by donor class-II positive MNL to the immune system of transfusion recipients is critical for the initiation of humoral immune response to donor MHC antigens.

scholarly journals Alternate Class I MHC Antigen Processing Is Inhibited by Toll-Like Receptor Signaling Pathogen-Associated Molecular Patterns:Mycobacterium tuberculosis19-kDa Lipoprotein, CpG DNA, and Lipopolysaccharide

2003 ◽  
Vol 171 (3) ◽  
pp. 1413-1422 ◽  
Author(s):  
Aaron A. R. Tobian ◽  
Nicholas S. Potter ◽  
Lakshmi Ramachandra ◽  
Rish K. Pai ◽  
Marilyn Convery ◽  
...  
Keyword(s):  
Antigen Processing ◽  
Class I ◽  
Receptor Signaling ◽  
Toll Like Receptor ◽  
Class I Mhc ◽  
Cpg Dna ◽  
Mhc Antigen

Resistance to NK Cell-Mediated Cytotoxicity (in K-562 Cells) does not Correlate with Class I MHC Antigen Levels

Immunobiology ◽  
1991 ◽  
Vol 183 (1-2) ◽  
pp. 23-39 ◽  
Author(s):  
Zvi Reiter ◽  
Yoram Reiter ◽  
Zvi Fishelson ◽  
Meir Shinitzky ◽  
Abraham Kessler ◽  
...  
Keyword(s):  
Nk Cell ◽  
Class I ◽  
Class I Mhc ◽  
K 562 Cells ◽  
Mhc Antigen

scholarly journals Structure and polymorphism of class I MHC antigen mRNA

1986 ◽  
Vol 24 (4) ◽  
pp. 278-278
Author(s):  
Ashwani K. Sood ◽  
Julian Pan ◽  
Paul A. Biro ◽  
Dennis Pereira ◽  
Rakesh Srivastava ◽  
...  
Keyword(s):  
Class I ◽  
Class I Mhc ◽  
Mhc Antigen
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