Factors affecting sensitivity to antitumor platinum derivatives of human colorectal tumor cell lines

2007 ◽  
Vol 62 (4) ◽  
pp. 577-584 ◽  
Author(s):  
Noriaki Kitada ◽  
Kohji Takara ◽  
Tetsuya Minegaki ◽  
Chihiro Itoh ◽  
Masayuki Tsujimoto ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Colorectal Tumor ◽  
Tumor Cell Lines ◽  
Factors Affecting ◽  
Colorectal Tumor Cell ◽  
Derivatives Of

scholarly journals Divergent patterns of incorporation of bromodeoxyuridine and iododeoxyuridine in human colorectal tumor cell lines

1991 ◽  
Vol 42 (1) ◽  
pp. 131-137 ◽  
Author(s):  
Jonathan Maybaum ◽  
Eric C. Burton ◽  
David A. Shelton ◽  
Hong-Wei Jing ◽  
Christine E. Dusenbury ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Colorectal Tumor ◽  
Tumor Cell Lines ◽  
Colorectal Tumor Cell

scholarly journals Di-2-pyridylketone 4, 4-dimethyl-3-thiosemicarbazone effectively induces human colorectal carcinoma cell apoptosis via mTOR pathway

2021 ◽  
Vol 3 (3) ◽  
pp. 56-62
Author(s):  
Qianqian Fu ◽  
Keyword(s):  
Colorectal Carcinoma ◽  
Tumor Cell ◽  
Cell Lines ◽  
Colorectal Tumor ◽  
Iron Chelators ◽  
Tumor Cell Lines ◽  
Human Colorectal Carcinoma ◽  
Colorectal Tumor Cell ◽  
Ht 29 ◽  
Additional Iron

Background: To investigate the anticancer mechanisms of di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) in human colon cancer cells. Human colorectal carcinoma (HCC) is one of the most commonly diagnosed cancers in both males and females. Current studies have found that iron chelators can be used as novel anticancer drugs; however, the anticancer activity of iron chelators and their target genes in HCC has been rarely reported. Methods: Dp44mT was used to treat two colorectal tumor cell lines, SW480 and HT-29. The proapoptotic effects of different concentrations of Dp44mt were measured using flow cytometry and Hoechst 33258 staining. Ferric ammonium citrate (FAC) was used as an additional iron donor to inhibit the effects of Dp44mT. Apoptosis and DNA damage-related proteins were examined by Western blot analysis. Results: In this study, we found that the iron chelators Dp44mT could induce the apoptosis in two colorectal tumor cell lines SW480 and HT-29, upregulate the expression level of p-histone H2A.X, and inhibit the phosphorylation level of mTOR in a dose-dependent way. Those effects could be reversed by the additional iron donor FAC. Conclusion: These data indicate that iron depletion and/or the presence of iron can modulate the HCC apoptosis progression in vitro, which may be a potential target for future HCC therapy.

Abstract LB-252: Expression of FGF-2 is essential for the maintenance of cancer stem cell characteristics in human colorectal tumor cell lines

2010 ◽  
Author(s):  
Silvio K. Scheel ◽  
Bikul Das ◽  
Lydia Kriegl ◽  
Reza B. Mukhthari ◽  
Micky Tsui ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Tumor Cell ◽  
Cell Lines ◽  
Colorectal Tumor ◽  
Tumor Cell Lines ◽  
Colorectal Tumor Cell

In vivo and in vitro antitumor activity of oxaliplatin in combination with cetuximab in human colorectal tumor cell lines expressing different level of EGFR

2005 ◽  
Vol 57 (6) ◽  
pp. 709-718 ◽  
Author(s):  
Diane Balin-Gauthier ◽  
Jean-Pierre Delord ◽  
Philippe Rochaix ◽  
Valérie Mallard ◽  
Fabienne Thomas ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Tumor Cell ◽  
Cell Lines ◽  
Colorectal Tumor ◽  
Tumor Cell Lines ◽  
Colorectal Tumor Cell

Seven genes that are differentially transcribed in colorectal tumor cell lines

2000 ◽  
Vol 160 (1) ◽  
pp. 37-43 ◽  
Author(s):  
Inko Nimmrich ◽  
Silke Erdmann ◽  
Ute Melchers ◽  
Ulrich Finke ◽  
Sebastian Hentsch ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Colorectal Tumor ◽  
Tumor Cell Lines ◽  
Colorectal Tumor Cell

Determinants of the cytotoxicity of irinotecan in two human colorectal tumor cell lines

2002 ◽  
Vol 49 (4) ◽  
pp. 329-335 ◽  
Author(s):  
Valérie Pavillard ◽  
Cécile Agostini ◽  
Sophie Richard ◽  
Virginie Charasson ◽  
Danièle Montaudon ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Colorectal Tumor ◽  
Tumor Cell Lines ◽  
Colorectal Tumor Cell

Loss of Human Leukocyte Antigen Expression on Colorectal Tumor Cell Lines

1993 ◽  
Vol 14 (3) ◽  
pp. 163-168 ◽  
Author(s):  
M. J. Browning ◽  
P. Krausa ◽  
A. Rowan ◽  
A. B. Hill ◽  
D. C. Bicknell ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Human Leukocyte Antigen ◽  
Cell Lines ◽  
Human Leukocyte ◽  
Antigen Expression ◽  
Colorectal Tumor ◽  
Tumor Cell Lines ◽  
Leukocyte Antigen ◽  
Colorectal Tumor Cell
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