Seven genes that are differentially transcribed in colorectal tumor cell lines

2000 ◽  
Vol 160 (1) ◽  
pp. 37-43 ◽  
Author(s):  
Inko Nimmrich ◽  
Silke Erdmann ◽  
Ute Melchers ◽  
Ulrich Finke ◽  
Sebastian Hentsch ◽  
...  
1991 ◽  
Vol 42 (1) ◽  
pp. 131-137 ◽  
Author(s):  
Jonathan Maybaum ◽  
Eric C. Burton ◽  
David A. Shelton ◽  
Hong-Wei Jing ◽  
Christine E. Dusenbury ◽  
...  

2007 ◽  
Vol 62 (4) ◽  
pp. 577-584 ◽  
Author(s):  
Noriaki Kitada ◽  
Kohji Takara ◽  
Tetsuya Minegaki ◽  
Chihiro Itoh ◽  
Masayuki Tsujimoto ◽  
...  

2021 ◽  
Vol 3 (3) ◽  
pp. 56-62
Author(s):  
Qianqian Fu ◽  

Background: To investigate the anticancer mechanisms of di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) in human colon cancer cells. Human colorectal carcinoma (HCC) is one of the most commonly diagnosed cancers in both males and females. Current studies have found that iron chelators can be used as novel anticancer drugs; however, the anticancer activity of iron chelators and their target genes in HCC has been rarely reported. Methods: Dp44mT was used to treat two colorectal tumor cell lines, SW480 and HT-29. The proapoptotic effects of different concentrations of Dp44mt were measured using flow cytometry and Hoechst 33258 staining. Ferric ammonium citrate (FAC) was used as an additional iron donor to inhibit the effects of Dp44mT. Apoptosis and DNA damage-related proteins were examined by Western blot analysis. Results: In this study, we found that the iron chelators Dp44mT could induce the apoptosis in two colorectal tumor cell lines SW480 and HT-29, upregulate the expression level of p-histone H2A.X, and inhibit the phosphorylation level of mTOR in a dose-dependent way. Those effects could be reversed by the additional iron donor FAC. Conclusion: These data indicate that iron depletion and/or the presence of iron can modulate the HCC apoptosis progression in vitro, which may be a potential target for future HCC therapy.


2010 ◽  
Author(s):  
Silvio K. Scheel ◽  
Bikul Das ◽  
Lydia Kriegl ◽  
Reza B. Mukhthari ◽  
Micky Tsui ◽  
...  

2005 ◽  
Vol 57 (6) ◽  
pp. 709-718 ◽  
Author(s):  
Diane Balin-Gauthier ◽  
Jean-Pierre Delord ◽  
Philippe Rochaix ◽  
Valérie Mallard ◽  
Fabienne Thomas ◽  
...  

2002 ◽  
Vol 49 (4) ◽  
pp. 329-335 ◽  
Author(s):  
Valérie Pavillard ◽  
Cécile Agostini ◽  
Sophie Richard ◽  
Virginie Charasson ◽  
Danièle Montaudon ◽  
...  

1993 ◽  
Vol 14 (3) ◽  
pp. 163-168 ◽  
Author(s):  
M. J. Browning ◽  
P. Krausa ◽  
A. Rowan ◽  
A. B. Hill ◽  
D. C. Bicknell ◽  
...  

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