PET–CT Evaluation of Solitary Pulmonary Nodules: Correlation with Maximum Standardized Uptake Value and Pathology

Lung ◽  
2013 ◽  
Vol 191 (6) ◽  
pp. 625-632 ◽  
Author(s):  
Yee Ting Sim ◽  
Yong Geng Goh ◽  
Mary Frances Dempsey ◽  
Sai Han ◽  
Fat Wui Poon
Keyword(s):  
Standardized Uptake Value ◽  
Pulmonary Nodules ◽  
Solitary Pulmonary Nodules ◽  
Maximum Standardized Uptake Value ◽  
Pet Ct ◽  
Ct Evaluation

scholarly journals Alavi–Carlsen Calcification Score (ACCS): A Simple Measure of Global Cardiac Atherosclerosis Burden

Diagnostics ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1421
Author(s):  
Babak Saboury ◽  
Lars Edenbrandt ◽  
Reza Piri ◽  
Oke Gerke ◽  
Tom Werner ◽  
...  
Keyword(s):  
Arterial Wall ◽  
Cardiac Ct ◽  
Standardized Uptake Value ◽  
Coronary Calcification ◽  
High Affinity ◽  
Maximum Standardized Uptake Value ◽  
Atherosclerotic Burden ◽  
Calcification Score ◽  
Pet Ct ◽  
The Individual

Multislice cardiac CT characterizes late stage macrocalcification in epicardial arteries as opposed to PET/CT, which mirrors early phase arterial wall changes in epicardial and transmural coronary arteries. With regard to tracer, there has been a shift from using mainly 18F-fluorodeoxyglucose (FDG), indicating inflammation, to applying predominantly 18F-sodium fluoride (NaF) due to its high affinity for arterial wall microcalcification and more consistent association with cardiovascular risk factors. To make NaF-PET/CT an indispensable adjunct to clinical assessment of cardiac atherosclerosis, the Alavi–Carlsen Calcification Score (ACCS) has been proposed. It constitutes a global assessment of cardiac atherosclerosis burden in the individual patient, supported by an artificial intelligence (AI)-based approach for fast observer-independent segmentation. Common measures for characterizing epicardial coronary atherosclerosis by NaF-PET/CT as the maximum standardized uptake value (SUV) or target-to-background ratio are more versatile, error prone, and less reproducible than the ACCS, which equals the average cardiac SUV. The AI-based approach ensures a quick and easy delineation of the entire heart in 3D to obtain the ACCS expressing ongoing global cardiac atherosclerosis, even before it gives rise to CT-detectable coronary calcification. The quantification of global cardiac atherosclerotic burden by the ACCS is suited for management triage and monitoring of disease progression with and without intervention.

scholarly journals Relationship between tumor mutational burden and maximum standardized uptake value in 2-[18F]FDG PET (positron emission tomography) scan in cancer patients

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Amin Haghighat Jahromi ◽  
Donald A. Barkauskas ◽  
Matthew Zabel ◽  
Aaron M. Goodman ◽  
Garret Frampton ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Standardized Uptake Value ◽  
Emission Tomography ◽  
Maximum Standardized Uptake Value ◽  
Tissue Biopsy ◽  
Mutational Burden ◽  
Positron Emission ◽  
Pet Ct ◽  
Tumor Mutational Burden ◽  
Fdg Pet Ct

Abstract Purpose Deriving links between imaging and genomic markers is an evolving field. 2-[18F]FDG PET/CT (18F-fluorodeoxyglucose positron emission tomography–computed tomography) is commonly used for cancer imaging, with maximum standardized uptake value (SUVmax) as the main quantitative parameter. Tumor mutational burden (TMB), the quantitative variable obtained using next-generation sequencing on a tissue biopsy sample, is a putative immunotherapy response predictor. We report the relationship between TMB and SUVmax, linking these two important parameters. Methods In this pilot study, we analyzed 1923 patients with diverse cancers and available TMB values. Overall, 273 patients met our eligibility criteria in that they had no systemic treatment prior to imaging/biopsy, and also had 2-[18F]FDG PET/CT within 6 months prior to the tissue biopsy, to ensure acceptable temporal correlation between imaging and genomic evaluation. Results We found a linear correlation between TMB and SUVmax (p < 0.001). In the multivariate analysis, only TMB independently correlated with SUVmax, whereas age, gender, and tumor organ did not. Conclusion Our observations link SUVmax in readily available, routinely used, and noninvasive 2-[18F]FDG PET/CT imaging to the TMB, which requires a tissue biopsy and time to process. Since higher TMB has been implicated as a prognostic biomarker for better outcomes after immunotherapy, further investigation will be needed to determine if SUVmax can stratify patient response to immunotherapy.

CT evaluation of solitary pulmonary nodules: value of 185-H reference phantom.

1991 ◽  
Vol 156 (5) ◽  
pp. 925-929 ◽  
Author(s):  
S J Swensen ◽  
G F Harms ◽  
R L Morin ◽  
J L Myers
Keyword(s):  
Pulmonary Nodules ◽  
Solitary Pulmonary Nodules ◽  
Reference Phantom ◽  
Ct Evaluation

Comparison of Quantitatively Analyzed Dynamic Area-Detector CT Using Various Mathematic Methods With FDG PET/CT in Management of Solitary Pulmonary Nodules

2013 ◽  
Vol 200 (6) ◽  
pp. W593-W602 ◽  
Author(s):  
Yoshiharu Ohno ◽  
Mizuho Nishio ◽  
Hisanobu Koyama ◽  
Yasuko Fujisawa ◽  
Takeshi Yoshikawa ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Pulmonary Nodules ◽  
Solitary Pulmonary Nodules ◽  
Area Detector ◽  
Pet Ct ◽  
Fdg Pet Ct

scholarly journals Dual time-point FDG PET-CT for differentiating benign from malignant solitary pulmonary nodules in a TB endemic area

2010 ◽  
Vol 100 (9) ◽  
pp. 598 ◽  
Author(s):  
Mike Machaba Sathekge ◽  
Alex Maes ◽  
Hans Pottel ◽  
Anton Stoltz ◽  
Christophe Van de Wiele
Keyword(s):  
Fdg Pet ◽  
Endemic Area ◽  
Pulmonary Nodules ◽  
Solitary Pulmonary Nodules ◽  
Pet Ct ◽  
Dual Time Point ◽  
Fdg Pet Ct ◽  
Time Point

scholarly journals Impact of solitary pulmonary nodule size on qualitative and quantitative assessment using 18F-fluorodeoxyglucose PET/CT: the SPUTNIK trial

2020 ◽  
Author(s):  
J. R. Weir-McCall ◽  
◽  
S. Harris ◽  
K. A. Miles ◽  
N. R. Qureshi ◽  
...  
Keyword(s):  
Multicentre Trial ◽  
Pulmonary Nodules ◽  
Blood Pool ◽  
Qualitative Assessment ◽  
Solitary Pulmonary Nodules ◽  
Nodule Size ◽  
Diagnostic Threshold ◽  
Pet Ct ◽  
The Impact

Abstract Purpose To compare qualitative and semi-quantitative PET/CT criteria, and the impact of nodule size on the diagnosis of solitary pulmonary nodules in a prospective multicentre trial. Methods Patients with an SPN on CT ≥ 8 and ≤ 30 mm were recruited to the SPUTNIK trial at 16 sites accredited by the UK PET Core Lab. Qualitative assessment used a five-point ordinal PET-grade compared to the mediastinal blood pool, and a combined PET/CT grade using the CT features. Semi-quantitative measures included SUVmax of the nodule, and as an uptake ratio to the mediastinal blood pool (SURBLOOD) or liver (SURLIVER). The endpoints were diagnosis of lung cancer via biopsy/histology or completion of 2-year follow-up. Impact of nodule size was analysed by comparison between nodule size tertiles. Results Three hundred fifty-five participants completed PET/CT and 2-year follow-up, with 59% (209/355) malignant nodules. The AUCs of the three techniques were SUVmax 0.87 (95% CI 0.83;0.91); SURBLOOD 0.87 (95% CI 0.83; 0.91, p = 0.30 versus SUVmax); and SURLIVER 0.87 (95% CI 0.83; 0.91, p = 0.09 vs. SUVmax). The AUCs for all techniques remained stable across size tertiles (p > 0.1 for difference), although the optimal diagnostic threshold varied by size. For nodules < 12 mm, an SUVmax of 1.75 or visual uptake equal to the mediastinum yielded the highest accuracy. For nodules > 16 mm, an SUVmax ≥ 3.6 or visual PET uptake greater than the mediastinum was the most accurate. Conclusion In this multicentre trial, SUVmax was the most accurate technique for the diagnosis of solitary pulmonary nodules. Diagnostic thresholds should be altered according to nodule size. Trial registration ISRCTN - ISRCTN30784948. ClinicalTrials.gov - NCT02013063

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