Alternating from subtotal thyroid resection to total thyroidectomy in the treatment of Graves’ disease prevents recurrences but increases the frequency of permanent hypoparathyroidism

2011 ◽  
Vol 397 (3) ◽  
pp. 407-412 ◽  
Author(s):  
Johannes Järhult ◽  
Per-Olof Andersson ◽  
Linda Duncker
Keyword(s):  
Total Thyroidectomy ◽  
Graves Disease ◽  
Permanent Hypoparathyroidism ◽  
Thyroid Resection

scholarly journals Association between number of parathyroid glands identified during total thyroidectomy and functional parathyroid preservation

2021 ◽  
Author(s):  
Fiona Riordan ◽  
Matthew S. Murphy ◽  
Linda Feeley ◽  
Patrick Sheahan
Keyword(s):  
Vitamin D ◽  
Multivariate Analysis ◽  
Total Thyroidectomy ◽  
Parathyroid Glands ◽  
Graves Disease ◽  
Permanent Hypoparathyroidism ◽  
Academic Teaching ◽  
Postoperative Hypoparathyroidism ◽  
Academic Teaching Hospital ◽  
Systematic Identification

Abstract Purpose Systematic identification of all 4 parathyroid glands has been recommended during total thyroidectomy (TT); however, it is unclear whether this strategy necessarily translates into optimized functional parathyroid preservation. We wished to investigate the association between number of parathyroids identified intraoperatively during TT, and incidence of incidental parathyroidectomy, and postoperative hypoparathyroidism. Methods Retrospective review of prospectively maintained database of 511 consecutive patients undergoing TT at an academic teaching hospital. The association between number of parathyroid glands identified intraoperatively and incidence of biochemical hypocalcaemia (defined as any calcium < 2 mmol/L n first 48 h after surgery), symptomatic hypocalcaemia; permanent hypoparathyroidism (defined as any hypocalcaemia or need for calcium or vitamin D > 6 months after surgery), and incidental parathyroidectomy, was investigated. The association between number of parathyroid glands visualized and postoperative parathyroid hormone (PTH) levels was investigated in a subset of 454 patients. Results Patients in whom a greater number of parathyroids had been identified had a significantly higher incidence of biochemical and symptomatic hypocalcaemia, and significantly lower postoperative PTH levels, than patients with fewer glands identified. There were no significant differences in incidence of permanent hypoparathyroidism or incidental parathyroidectomy. On multivariate analysis, malignancy, Graves disease, and identification of 3–4 parathyroids were independent predictors of biochemical hypocalcaemia. For symptomatic hypocalcaemia, identification of 2–4 parathyroids, and identification of 3–4 parathyroids, were significant. Conclusions Systematic identification of as many parathyroid glands as possible during TT is not necessary for functional parathyroid preservation.

scholarly journals Surgical procedures in patients with thyroid autoimmune disease

2005 ◽  
Vol 133 (Suppl. 1) ◽  
pp. 77-83 ◽  
Author(s):  
Aleksandar Diklic ◽  
Vladan Zivaljevic ◽  
Ivan Paunovic ◽  
Nevena Kalezic ◽  
Svetislav Tatic
Keyword(s):  
Total Thyroidectomy ◽  
Surgical Procedures ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Postoperative Bleeding ◽  
Hashimoto Thyroiditis ◽  
Graves Disease ◽  
Permanent Hypoparathyroidism ◽  
Autoimmune Thyroid ◽  
Toxic Goiter

Autoimmune thyroid disease is a serious medical problem in which various operative procedures are performed. The objective of the study is to explore the type of applied surgical procedures in autoimmune thyroid disease, advantages and disadvantages of various procedures, and criteria they have to meet. This is retrospective clinical study on 1478 patients, operated for Graves? toxic goiter (117 males and 795 females mean age 37.7) and Hashimoto thyroiditis (27 males and 539 females mean age 50.6) from 1995 to April 2005. Cancer in Graves? disease was found in 61 patients (6.7%), papillary in 60 (occult in 53 or 6.6%) and metastatic in 1, Hashimoto thyroiditis and thyroid cancer was found in 141 patients (24.9%), papillary in 116 or 20.5% (occult in 55 or 9.7%), follicular in 2 (0.3%), Hurthle in 11 (1.9%), medullary in 8 (1.4%), anaplastic in 2 (0.3%) and lymphoma in 3 (0.5%). We performed subtotal bilateral lobectomy in 344 (312 in Graves and 32 in Hashimoto), total lobectomy on one side with subtotal on the oposite in 307 (228 in Graves and 79 in Hashimoto); out of them, in 59 patients, the remnant was left in the region of the upper pole which we called atypic lobectomy. The most common procedure, total or near by total thyroidectomy, performed in 719 (371 in Graves and 349 in Hashimoto). One side lobectomy was performed in 103 patients with Hashimoto thyroiditis. Lymph node dissection was performed in 21 ( 1 in Graves and 20 in Hashimoto), in all central, in 10 lateral functional and in 6 mediastinal, in 15 patients with cancer and in 6 patients with benign disease. There was no operative mortality. In Graves? disease, there was postoperative bleeding in 4 (0.4%), wound infection in 2 (0.2%) recurrent pulsy in 18 (2%) and permanent hypoparathyroidism in 13 (1.4%). In Hashimoto thyroiditis, there was postoperative bleeding in 2 (0.4%), recurrent nerve pulsy in 11 (1.9%) and permanent hypoparathyroidism in 6 (1.1%). The most common surgical procedure in autoimmune thyroid disease is total thyroidectomy which is followed by low complication rate in specialised centers. Cancer is more frequent in Hashimoto than in Graves? disease.

The association between the levels of the TSI antibodies and thyroid cancer among patients with Graves' disease who have undergone total thyroidectomy

2019 ◽  
Author(s):  
Georgios Boutzios ◽  
Eugenia Kotsifa ◽  
Nefeli Tomara ◽  
Eleni Koukoulioti ◽  
Zoe Garoufalia ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Total Thyroidectomy ◽  
Graves Disease

Influence of Total Thyroidectomy on Orbital Opthalmopathy and Levels of Antithyroid Antibodies in Patients with Graves' Disease

2007 ◽  
Vol 79 (3) ◽  
Author(s):  
Paweł Domosławski ◽  
Tadeusz Łukieńczuk ◽  
Zdzisław Forkasiewicz ◽  
Waldemar Balcerzak ◽  
Wiktor Bednarz ◽  
...  
Keyword(s):  
Total Thyroidectomy ◽  
Graves Disease ◽  
Antithyroid Antibodies

Serum thyroglobulin and its autoantibody following subtotal thyroid resection of Graves' disease

1982 ◽  
Vol 12 (3) ◽  
pp. 203-208 ◽  
Author(s):  
ULLA FELDT-RASMUSSEN ◽  
M. BLICHERT-TOFT ◽  
C. CHRISTIANSEN ◽  
J. DATE
Keyword(s):  
Graves Disease ◽  
Serum Thyroglobulin ◽  
Thyroid Resection

Patient-Reported Outcomes Following Total Thyroidectomy for Graves' Disease

Thyroid ◽  
2021 ◽  
Author(s):  
Alexander H Gunn ◽  
Nicholas Frisco ◽  
Samantha Thomas ◽  
Michael Stang ◽  
Randall P. Scheri ◽  
...  
Keyword(s):  
Total Thyroidectomy ◽  
Patient Reported Outcomes ◽  
Graves Disease ◽  
Patient Reported

scholarly journals Surgical Treatment of Graves' Disease: Comparison between Total Thyroidectomy and Subtotal Thyroidectomy

2009 ◽  
Vol 77 (2) ◽  
pp. 82 ◽  
Author(s):  
Tae-Yon Sung ◽  
Yon Seon Kim ◽  
Sook Hyun Lee ◽  
Jong Ho Yoon ◽  
Suk-Joon Hong
Keyword(s):  
Surgical Treatment ◽  
Total Thyroidectomy ◽  
Subtotal Thyroidectomy ◽  
Graves Disease

scholarly journals Change of surgical strategy for Graves’ disease from subtotal thyroidectomy to total thyroidectomy: a single institutional experience

2019 ◽  
Vol 66 (2) ◽  
pp. 181-186
Author(s):  
Kiminori Sugino ◽  
Mitsuji Nagahama ◽  
Wataru Kitagawa ◽  
Keiko Ohkuwa ◽  
Takashi Uruno ◽  
...  
Keyword(s):  
Total Thyroidectomy ◽  
Subtotal Thyroidectomy ◽  
Surgical Strategy ◽  
Graves Disease ◽  
Institutional Experience
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