Pancrelipase with branched-chain amino acids for preventing nonalcoholic fatty liver disease after pancreaticoduodenectomy

2015 ◽  
Vol 51 (1) ◽  
pp. 55-62 ◽  
Author(s):  
Shintaro Yamazaki ◽  
Tadatoshi Takayama ◽  
Tokio Higaki ◽  
Masamichi Moriguchi ◽  
Nao Yoshida ◽  
...  
Keyword(s):  
Amino Acids ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Branched Chain Amino Acids ◽  
Nonalcoholic Fatty Liver ◽  
Branched Chain

scholarly journals Circulating branch chain amino acids and improvement in liver fat content in response to exercise interventions in NAFLD

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xiulin Shi ◽  
Hongyan Yin ◽  
Jia Li ◽  
Caoxin Huang ◽  
Yinling Chen ◽  
...  
Keyword(s):  
Amino Acids ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Branched Chain Amino Acids ◽  
Fat Content ◽  
Liver Fat ◽  
Liver Fat Content ◽  
Nonalcoholic Fatty Liver ◽  
Branched Chain

AbstractNonalcoholic fatty liver disease is likely to be associated with increased circulating branched-chain amino acids. We investigated the relationship between changes in branched-chain amino acids levels in the serum and improvement in liver fat content caused by exercise intervention in individuals with nonalcoholic fatty liver disease. The exploratory study included 208 central obesity and nonalcoholic fatty liver disease individuals from an exercise intervention randomized clinical trial for nonalcoholic fatty liver disease. The participants were randomly assigned to control, moderate, and vigorous-moderate exercise groups for 12 months. Changes in total branched-chain amino acids, leucine, isoleucine, and valine levels from baseline to 6 months were calculated. Liver fat content was determined by proton magnetic resonance spectroscopy. Reductions in circulating levels of total branched-chain amino acids, leucine, and valine levels from baseline to 6 months were significantly associated with the improvement of liver fat content at 6 months and 12 months (p < 0.01 for all) after adjustments for age, sex, total energy intake, protein intake, intervention groups, HOMA-IR, BMI, liver fat content, total branched-chain amino acids, leucine, and valine at baseline, respectively. These associations were still significant after further adjustments for changes in HOMA-IR and BMI from baseline to 6 months (p < 0.05 for all). Our findings indicated that reductions in circulating branched-chain amino acids levels were associated with an improvement in liver fat content by exercise intervention among patients with nonalcoholic fatty liver disease, which was independent of changes in BMI or HOMA-IR.

scholarly journals Branched chain amino acid metabolism profiles in progressive human nonalcoholic fatty liver disease

Amino Acids ◽  
2014 ◽  
Vol 47 (3) ◽  
pp. 603-615 ◽  
Author(s):  
April D. Lake ◽  
Petr Novak ◽  
Petia Shipkova ◽  
Nelly Aranibar ◽  
Donald G. Robertson ◽  
...  
Keyword(s):  
Liver Disease ◽  
Amino Acid ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Nonalcoholic Fatty Liver ◽  
Branched Chain Amino Acid ◽  
Branched Chain

scholarly journals Citrulline and Nonessential Amino Acids Prevent Fructose-Induced Nonalcoholic Fatty Liver Disease in Rats

2015 ◽  
Vol 145 (10) ◽  
pp. 2273-2279 ◽  
Author(s):  
Prasanthi Jegatheesan ◽  
Stéphanie Beutheu ◽  
Gabrielle Ventura ◽  
Esther Nubret ◽  
Gilles Sarfati ◽  
...  
Keyword(s):  
Amino Acids ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver ◽  
Nonessential Amino Acids
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