Bartonella henselae is usually not viable in lymph nodes of patients with cat scratch disease

2017 ◽  
Vol 36 (11) ◽  
pp. 2207-2213 ◽  
Author(s):  
E. Prudent ◽  
H. Lepidi ◽  
G. Audoly ◽  
B. La Scola ◽  
P.-E. Fournier ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Bartonella Henselae ◽  
Cat Scratch Disease

scholarly journals Felinosis: the elusive-cat scratch disease

2019 ◽  
Vol 5 (2) ◽  
pp. 511
Author(s):  
S. Arulmozhi ◽  
Sithananda Kumar ◽  
Shilpa Divakaran ◽  
Susy Sophia Kurian ◽  
Mary Kurien
Keyword(s):  
Lymph Nodes ◽  
Children And Adolescents ◽  
Chronic Inflammation ◽  
Male Patient ◽  
Bartonella Henselae ◽  
Clinical Manifestations ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Cat Scratch Disease ◽  
Suppurative Lymphadenitis

<p class="abstract">Cat-scratch disease or felinosis is an infection caused by <em>Bartonella henselae</em> which is characterized by chronic inflammation of the lymph nodes. It is one of the causes of regional, unilateral adenitis in children and adolescents. Axillary lymph nodes followed by cervical, pre-auricular and submandibular lymph nodes are the most common sites of involvement. We report a 14 year old male patient with cat scratch disease in whom the initial clinical manifestations were indistinguishable from those of acute bacterial suppurative lymphadenitis.</p>

scholarly journals Detection by Immunofluorescence Assay of Bartonella henselae in Lymph Nodes from Patients with Cat Scratch Disease

2003 ◽  
Vol 10 (4) ◽  
pp. 686-691 ◽  
Author(s):  
J. M. Rolain ◽  
F. Gouriet ◽  
M. Enea ◽  
M. Aboud ◽  
D. Raoult
Keyword(s):  
Lymph Nodes ◽  
Bartonella Henselae ◽  
Laboratory Diagnosis ◽  
Immunofluorescence Assay ◽  
Cat Scratch Disease ◽  
Specific Monoclonal Antibody ◽  
Pcr Assay ◽  
Serology Test ◽  
Negative Lymph Nodes ◽  
Immunocompetent Patients

ABSTRACT Laboratory diagnosis of Bartonella henselae infections can be accomplished by serology or PCR assay on biopsy samples. The purpose of our work was to assess immunofluorescence detection (IFD) in lymph node smears using a specific monoclonal antibody directed against B. henselae and a commercial serology assay (IFA) compared with PCR detection. Among 200 lymph nodes examined from immunocompetent patients, 54 were positive for B. henselae by PCR, of which 43 were also positive by IFD. Among the 146 PCR-negative lymph nodes, 11 were positive by IFD. Based on PCR results, the specificity of this new technique was 92.5%, the sensitivity was 79.6%, and the positive predictive value was 79.6%. At a cutoff titer of 64, the sensitivity of the IFA was 86.8% and the specificity was 74.1%. Diagnosis of cat scratch disease (CSD) may be improved, with a specificity of 100%, when the two tests (IFD and IFA) were negative; the sensitivity was 97.4% if one of the two tests was positive. Since PCR-based detection with biopsy samples is available only in reference laboratories, we suggest using IFD coupled with the commercial serology test for the diagnosis of CSD.

Other bacterial diseasesCat-scratch disease

2011 ◽  
Author(s):  
Michel Drancourt
Keyword(s):  
Lymph Nodes ◽  
Bartonella Henselae ◽  
Severe Disease ◽  
Formal Description ◽  
Cat Scratch Disease ◽  
Bacillary Angiomatosis ◽  
Children And Young Adults ◽  
Eye Infection ◽  
Rough Play ◽  
Spleen Enlargement

Cat-scratch disease (CSD) is a worldwide zoonoses caused by infection with the bacterium, Bartonella henselae. The formal description of the disease by Debré in 1950 (Debré et al. 1950) corresponds to the most frequently diagnosed form of the disease. Cats are the main reservoir for B. henselae and transmission is via Ctniocephalides felis. Humans usually become infected after being scratched or bitten by a cat and is most frequently seen in children and young adults.CSD is a self-limiting illness which often begins with a small papule developing at the site of cat scratch or bite within 3-14 days of the infection. Nearby lymph nodes, usually neck, axillary or groin, become swollen and can persist for several months. It may take up to 7 weeks for the enlarged lymph nodes to appear and individuals may not recall any cat scratch or bite. In healthy cases antibiotics are not indicated.About 5-10% of patients may develop other forms of CSD including eye infection characterised by conjunctivitis and swollen lymph nodes, rash, liver and spleen enlargement, and more rarely encephalitis. Immunosuppresed patients may develop more severe disease, such as bacillary angiomatosis.General advice for preventing CSD includes avoiding rough play with cats, particularly kittens. Cat scratches and bites should be washed immediately with water and soap and cats should not be allowed to lick open wounds.

scholarly journals Beyond Cat Scratch Disease: A Case Report ofBartonellaInfection Mimicking Vasculitic Disorder

2012 ◽  
Vol 2012 ◽  
pp. 1-4
Author(s):  
Amelia Spinella ◽  
Federica Lumetti ◽  
Gilda Sandri ◽  
Valentina Cestelli ◽  
Maria Teresa Mascia
Keyword(s):  
Case Report ◽  
Lymph Nodes ◽  
Bartonella Henselae ◽  
Skin Lesions ◽  
Bacterial Disease ◽  
Cat Scratch Disease ◽  
History Of ◽  
Vasculitic Disorder

Cat scratch disease (CSD) is a bacterial disease caused byBartonella henselaeand it is mainly characterized by self-limiting lymphadenopathy in the draining site of a cat scratch or bite. We report a patient with history of fever, swelling lymph nodes, vasculitic-like skin lesions, and positivity ofBartonellaserology initially considered as expression of a disimmune disease.

Cat scratch disease: a diagnostic conundrum

2009 ◽  
Vol 20 (8) ◽  
pp. 585-586 ◽  
Author(s):  
C Scott ◽  
A Azwa ◽  
C Cohen ◽  
M McIntyre ◽  
N Desmond
Keyword(s):  
Lymph Nodes ◽  
Causative Agent ◽  
Bartonella Henselae ◽  
Lymphogranuloma Venereum ◽  
Cat Scratch Disease ◽  
Inguinal Lymphadenopathy ◽  
Animal Exposure

We report the case of a patient who presented to a clinic for evaluation of inguinal lymphadenopathy. Histology of the lymph nodes revealed micoabscess formation suggesting infection with Lymphogranuloma venereum (LGV) or Bartonella henselae – the causative agent in cat scratch disease (CSD). The patient recalled no preceding animal exposure. Clinical and serological findings initially suggested early LGV but convalescent serology supported CSD. This serves as an important reminder that B. henselae infection should be considered a cause of regional lymphadenopathy in individuals suspected of having LGV.

scholarly journals Detection of Bartonella henselae DNA by Two Different PCR Assays and Determination of the Genotypes of Strains Involved in Histologically Defined Cat Scratch Disease

1999 ◽  
Vol 37 (4) ◽  
pp. 993-997 ◽  
Author(s):  
Anna Sander ◽  
Miriam Posselt ◽  
Norbert Böhm ◽  
Michael Ruess ◽  
Martin Altwegg
Keyword(s):  
Lymph Nodes ◽  
Bartonella Henselae ◽  
Pcr Amplification ◽  
Laboratory Diagnosis ◽  
Etiologic Agent ◽  
Rrna Gene ◽  
Cat Scratch Disease ◽  
Genotype I ◽  
Specific Pcr ◽  
Pcr Assays

Cat scratch disease (CSD) is a common cause of subacute regional lymphadenopathy, not only in children but also in adults. Serological and molecular studies demonstrated that Bartonella henselaeis the etiologic agent in most cases of CSD. Amplification of B. henselae DNA in affected tissue and detection of antibodies toB. henselae are the two mainstays in the laboratory diagnosis of CSD. We designed a retrospective study and investigated formalin-fixed, paraffin-embedded lymph nodes from 60 patients (25 female, 35 male) with histologically suspected CSD by PCR amplification. The sensitivities of two different PCR assays were compared. The first primer pair amplified a 296-bp fragment of the 16S rRNA gene in 36 of the 60 samples, corresponding to a sensitivity of 60%. The second primer pair amplified a 414-bp fragment of thehtrA gene in 26 of the 60 lymph nodes, corresponding to a sensitivity of 43.3%. Bartonella DNA could be detected in a total of 39 (65%) of the 60 lymph nodes investigated. However, histopathologic findings are typical but not specific for CSD and cannot be considered as a “gold standard” for diagnosis of CSD. The sensitivity of the PCR assays increased from 65 to 87% if two criteria (histology and serology) were used in combination for diagnosis of CSD. Two genotypes (I and II) of B. henselae are described as being involved in CSD. Genotype I was found in 23 (59%) and genotype II was found in 9 (23%) of the 39 PCR-positive lymph nodes. Seven (18%) lymph nodes were negative in both type-specific PCR assays. Thirty (50%) of our 60 patients were younger than 20 years old (15 were younger than 10 years), 20 (33%) were between 21 and 40 years old, and 10 (17%) patients were between 41 and 84 years old. Our data suggest that detection of Bartonella DNA in patients’ samples might confirm the histologically suspected diagnosis of CSD.

scholarly journals Cervical Cat Scratch Disease Lymphadenitis in a Patient with Immunoglobulin M Antibodies to Toxoplasma gondii

2002 ◽  
Vol 9 (2) ◽  
pp. 496-498
Author(s):  
Mardjan Arvand ◽  
Ilkay Kazak ◽  
Sergije Jovanovic ◽  
Hans-Dieter Foss ◽  
Oliver Liesenfeld
Keyword(s):  
Toxoplasma Gondii ◽  
Clinical Symptoms ◽  
Bartonella Henselae ◽  
Cervical Lymphadenopathy ◽  
Immunoglobulin M ◽  
Cat Scratch Disease ◽  
Specific Immunoglobulin ◽  
Acute Toxoplasmosis

ABSTRACT We report on a young patient with chronic cervical lymphadenopathy and serological and histological evidence for infection with Bartonella henselae and Toxoplasma gondii. Serological follow-up studies, including testing for avidity of Toxoplasma-specific immunoglobulin G antibodies, assisted in the determination of the cause of the acute lymphadenitis. Our results suggest that the clinical symptoms were most likely due to cat scratch disease rather than to acute toxoplasmosis.

Positional Hand Pallor and Isolated Epitrochlear Lymphadenitis Secondary to Bartonella henselae Infection.

2021 ◽  
Vol 20 (4) ◽  
pp. 914-917
Author(s):  
Siti Nuradliah Jamil ◽  
Ilham Ameera Ismail ◽  
Siti Fatimah Badlishah Sham ◽  
Norliana Dalila Mohamad Ali
Keyword(s):  
Lymph Node ◽  
Communicable Disease ◽  
Bartonella Henselae ◽  
Medical Science ◽  
Neck Region ◽  
Rare Condition ◽  
Cat Scratch Disease ◽  
Serological Evidence ◽  
External Compression ◽  
Head And Neck Region

Cat scratch disease is a communicable disease caused by the Bartonella henselae bacteria. Regional lymphadenopathy is the hallmark of cat scratch disease and about 75% of lymphadenopathy cases are localized in the head and neck region. An epitrochlear lymphadenopathy is a rare condition at any age and often misdiagnosed as it is not normally palpable. External compression of an enlarged epitrochlear lymph node compromising vascularity was not mentioned in any literature before. We present a case of a 13-year-old girl with right positional ipsilateral hand pallor and epitrochlear lymphadenitis with serological evidence of Bartonella henselae infection. Bangladesh Journal of Medical Science Vol.20(4) 2021 p.914-917

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