Kinetic Degradation Study of Ipragliflozin Coupled with MS/MS Structural Elucidation

2022 ◽  
Author(s):  
Manar M. Elhassan ◽  
Amr M. Mahmoud ◽  
Maha A. Hegazy ◽  
Shereen Mowaka
Keyword(s):  
Structural Elucidation ◽  
Degradation Study

Degradation study of irbesartan: Isolation and structural elucidation of novel degradants

2018 ◽  
Vol 157 ◽  
pp. 180-188 ◽  
Author(s):  
V.V.S.R.N. Anji Karun Mutha ◽  
Santhosh Guduru ◽  
Muralidharan Kaliyaperumal ◽  
Chidananda Swamy Rumalla ◽  
Srinivasa Rao Maddi ◽  
...  
Keyword(s):  
Structural Elucidation ◽  
Degradation Study

Characterization of stress degradation products of blonanserin by UPLC-QTOF-tandem mass spectrometry

RSC Advances ◽  
2015 ◽  
Vol 5 (85) ◽  
pp. 69273-69288 ◽  
Author(s):  
Pradipbhai D. Kalariya ◽  
Prinesh N. Patel ◽  
Mahesh Sharma ◽  
Prabha Garg ◽  
R. Srinivas ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
Tandem Mass Spectrometry ◽  
Degradation Products ◽  
Structural Elucidation ◽  
Forced Degradation ◽  
Tandem Mass ◽  
Degradation Study ◽  
Stress Degradation

Forced degradation study of blonanserin and structural elucidation of its degradation products was performed using high resolution tandem mass spectrometry.

Hydrolytic Degradation Study of Dabigatran Etexilate Mesylate: Isolation and Structural Elucidation of New Degradants

2018 ◽  
Vol 8 (3) ◽  
pp. 277-286
Author(s):  
V.V.S.R.N. Anji Karun Mutha ◽  
B.V. Narasimha Raju Katari ◽  
Muralidharan Kaliyaperumal ◽  
Chidananda Swamy Rumalla ◽  
Raghu Babu Korupolu ◽  
...  
Keyword(s):  
Dabigatran Etexilate ◽  
Hydrolytic Degradation ◽  
Structural Elucidation ◽  
Degradation Study

Isolation and structural elucidation of novel natural compounds from twigs of Pinus banksiana

Planta Medica ◽  
2013 ◽  
Vol 79 (13) ◽  
Author(s):  
C Si ◽  
X Ren ◽  
S Liu ◽  
G Xu ◽  
J Jiang
Keyword(s):  
Pinus Banksiana ◽  
Natural Compounds ◽  
Structural Elucidation

Isolation and structural elucidation of secondary metabolites obtained from the soft coral Sinularia candidula present in the Egyptian Red Sea

Planta Medica ◽  
2015 ◽  
Vol 81 (16) ◽  
Author(s):  
RF Abou El Ezz ◽  
M Afifi ◽  
A Kamal ◽  
E Sannad ◽  
M Radwan ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Red Sea ◽  
Soft Coral ◽  
Structural Elucidation

Detection, Identification and Structural Elucidation of Flavonoids using Liquid Chromatography Coupled to Mass Spectrometry

2020 ◽  
Vol 24 (1) ◽  
pp. 104-112 ◽  
Author(s):  
Krzysztof Kamil Wojtanowski ◽  
Tomasz Mroczek
Keyword(s):  
Mass Spectrometry ◽  
Central Nervous System ◽  
Nuclear Magnetic Resonance ◽  
Liquid Chromatography ◽  
High Performance ◽  
Short Review ◽  
Structural Elucidation ◽  
High Throughput Analysis ◽  
Protective Actions ◽  
The Central Nervous System

Flavonoids are one of the most common secondary metabolites occurring in plants. Their activity in the Central Nervous System (CNS) including sedative, anxiolytic, anti-convulsive, anti-depressant and neuro-protective actions is well known and documented. The most popular methods for detection, identification and structural elucidation of flavonoids are these based on Nuclear Magnetic Resonance (NMR) and mass spectrometry (MS). NMR allows rapid, high throughput analysis of crude extracts and also gives stereochemical details about identified substances. However, these methods are expensive and less sensitive than MS-based techniques. Combining High Performance Liquid Chromatography (HPLC) with MS detection gives the most powerful tool for analysis of flavonoids occurring in plants. There is a lot of different approaches to use LC/MS based techniques for identification of flavonoids and this short review shows the most important.

Synthesis and Characterization of Potential and Degraded Impurities of Regadenoson

2020 ◽  
Vol 16 (8) ◽  
pp. 1130-1139
Author(s):  
Singaram Sathiyanarayanan ◽  
Chidambaram Subramanian Venkatesan ◽  
Senthamaraikannan Kabilan
Keyword(s):  
Mass Spectra ◽  
Degradation Products ◽  
Hplc Method ◽  
Forced Degradation ◽  
Spectroscopic Techniques ◽  
A2a Adenosine Receptor ◽  
Degradation Study ◽  
Related Substances ◽  
Adenosine Receptor Agonist

Background: Regadenoson is an A2A adenosine receptor agonist that is a coronary vasodilator and commonly used as a pharmacologic cardiac stressing agents. Methods: HPLC method was used for the analysis of related substances. The degraded impurities during the process were isolated and characterized by IR, Mass and NMR spectral analysis. Results: Forced degradation study of regadenoson under conditions of hydrolysis (neutral, acidic and alkaline) and oxidations suggested in the ICH Q1A(R2) was accomplished. The drug showed significant degradation under all the above conditions. On the whole, five novel degradation products were found under diverse conditions along with process related impurities which were not reported earlier. Conclusion: All the degradation products were well characterized by using advanced spectroscopic techniques like IR, 1H NMR, 13C NMR and Mass spectra. The identification of these impurities will be productive for the quality control during the production and stability behavior of the regadenoson drug substance.

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