Spike Activity in the Ventromedial Nucleus of Rat Hypothalamus during Aging

2021 ◽  
Author(s):  
K. Yu. Moiseev ◽  
A. A. Spirichev ◽  
L. G. Pankrasheva ◽  
A. S. Martyusheva ◽  
A. Yu. Abramova ◽  
...  
Keyword(s):  
Spike Activity ◽  
Ventromedial Nucleus ◽  
Rat Hypothalamus

Spike electric activity in the ventromedial nucleus of the rat hypothalamus during aging

2021 ◽  
Vol 171 (2) ◽  
pp. 219-222
Author(s):  
K. Yu. Moiseev ◽  
◽  
A. A. Spirichev ◽  
L. G. Pankrasheva ◽  
A. S. Martyusheva ◽  
...  
Keyword(s):  
Electric Activity ◽  
Ventromedial Nucleus ◽  
Rat Hypothalamus

Dose response to carbachol and norepinephrine in rat hypothalamus

1964 ◽  
Vol 206 (6) ◽  
pp. 1384-1388 ◽  
Author(s):  
Neal E. Miller ◽  
Kay S. Gottesman ◽  
Nona Emery
Keyword(s):  
Dose Response ◽  
Weak Solutions ◽  
Ventromedial Nucleus ◽  
Liquid Food ◽  
Rat Hypothalamus ◽  
Higher Doses

One microliter of various concentrations of carbachol or norepinephrine was injected via a chronic cannula into the "feeding-drinking" area of the hypothalamus of satiated rats. Doses of 2.7 through 24 x 10–10 m of carbachol elicited drinking of increasing amounts of water, but progressively higher doses elicited less drinking, some lethargy, and then convulsions. Similar, but probably less, responsiveness occurred to injections of the ventromedial nucleus. Control and weak solutions did not elicit drinking; no dose of carbachol elicited appreciable eating of solid, or drinking of a liquid food, namely, a Metrecal solution made slightly salty so that normally thirsty rats preferred water to it. Doses of from 24 through 216 x 10–10 m norepinephrine elicited drinking of salty Metrecal ( P < .10), while 648 x 10–10 m elicited reliable consumption of this food. Still higher doses elicited less "eating," some lethargy, and eventually a few convulsions. Control and weak injections did not elicit eating. No drinking of water was elicited at any level of norepinephrine. Histologically determined placement of cannulas correlated with amount of response for both substances.

Evoked release of [14C]norepinephrine from the rat hypothalamus during feeding

1975 ◽  
Vol 229 (6) ◽  
pp. 1547-1555 ◽  
Author(s):  
GE Martin ◽  
RD Myers
Keyword(s):  
Cerebrospinal Fluid ◽  
Food Intake ◽  
Lateral Ventricle ◽  
Ventromedial Hypothalamus ◽  
Catecholamine Release ◽  
Ventromedial Nucleus ◽  
Rat Hypothalamus ◽  
Artificial Cerebrospinal Fluid ◽  
Sensory Motor ◽  
Endogenous Catecholamines

The pattern of catecholamine release was studied at sites adjacent to the lateral ventricle or in the anterior, dorsomedial or ventromedial hypothalamus of the rat as it was feeding. Endogenous stores of norepinephrine (NE) were first labeled by the microinjection of [14C]NE into these circumscribed sites. Subsequently, [14C]NE release was examined by repeated perfusions of an artificial cerebrospinal fluid through a push-pull cannula at the rate of 23 mul/min for 5-10 min every 30 min. After successive control perfusates were collected, food or water was given to the animal. During an interval of feeding, a significant efflux of [14C]NE and its metabolites occurred reliably from midline structures of the hypothalamus at the level of the ventromedial nucleus. Although the feeding-related output of [14C]NE detected within the anterior hypothalamus was lower, [14C]NE was also released from this region when the rat pressed a lever to obtain food pellets. These results support the view that endogenous catecholamines underlie, at least partially, diencephalic mechanisms controlling food intake, including sensory, motor, or motivational components.

Tremor-correlated spike activity in Parkinson's disease detected in a distributed subthalamic network

2006 ◽  
Vol 37 (01) ◽  
Author(s):  
A Florian ◽  
K Henschel ◽  
B Schelter ◽  
M Winterhalder ◽  
B Guschlbauer ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Spike Activity
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