scholarly journals Differences in breast cancer-risk factors between screen-detected and non-screen-detected cases (MCC-Spain study)

2021 ◽  
Author(s):  
Marta Hernández-García ◽  
Ana Molina-Barceló ◽  
Mercedes Vanaclocha-Espi ◽  
Óscar Zurriaga ◽  
Beatriz Pérez-Gómez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Risk Factor ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Postmenopausal Women ◽  
Regression Models ◽  
Detection Method ◽  
Age At Menopause ◽  
Tumor Phenotype

Abstract Purpose The variation in breast cancer (BC)-risk factor associations between screen-detected (SD) and non-screen-detected (NSD) tumors has been poorly studied, despite the interest of this aspect in risk assessment and prevention. This study analyzes the differences in breast cancer-risk factor associations according to detection method and tumor phenotype in Spanish women aged between 50 and 69. Methods We examined 900 BC cases and 896 controls aged between 50 and 69, recruited in the multicase–control MCC-Spain study. With regard to the cases, 460 were detected by screening mammography, whereas 144 were diagnosed by other means. By tumor phenotype, 591 were HR+, 153 were HER2+, and 58 were TN. Lifestyle, reproductive factors, family history of BC, and tumor characteristics were analyzed. Logistic regression models were used to compare cases vs. controls and SD vs. NSD cases. Multinomial regression models (controls used as a reference) were adjusted for case analysis according to phenotype and detection method. Results TN was associated with a lower risk of SD BC (OR 0.30 IC 0.10–0.89), as were intermediate (OR 0.18 IC 0.07–0.44) and advanced stages at diagnosis (OR 0.11 IC 0.03–0.34). Nulliparity in postmenopausal women and age at menopause were related to an increased risk of SD BC (OR 1.60 IC 1.08–2.36; OR 1.48 IC 1.09–2.00, respectively). Nulliparity in postmenopausal women was associated with a higher risk of HR+ (OR 1.66 IC 1.15–2.40). Age at menopause was related to a greater risk of HR+ (OR 1.60 IC 1.22–2.11) and HER2+ (OR 1.59 IC 1.03–2.45) tumors. Conclusion Reproductive risk factors are associated with SD BC, as are HR+ tumors. Differences in BC-risk factor associations according to detection method may be related to prevailing phenotypes among categories.

Breast cancer epidemiologic risk factors by HER2/neu status

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 585-585
Author(s):  
W. Y. Chen ◽  
G. A. Colditz ◽  
B. Rosner
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Risk Factor ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Benign Breast Disease ◽  
Breast Disease ◽  
Breast Cancers ◽  
Cancer Risk Factors ◽  
Breast Cancer Risk Factors

585 Background: Although breast cancers categorized by estrogen receptor (ER) and progesterone receptor (PR) status are recognized to differ in their associations with standard breast cancer risk factors, little data exist on differences by HER2/neu status. Methods: The Nurses’ Health Study is a prospective cohort study of 121,700 registered nurses aged 30–55 in 1976 who answered biennial questionnaires to update medical and lifestyle factors and disease occurrence. Medical record review was used to confirm invasive breast cancer and abstract ER, PR, and HER2/neu status. Statistical analyses included both proportional hazards models to estimate relative risks and control for potential confounders and polytomous logistic regression to compare the effects. Only cases diagnosed from return of the 1998 questionnaire until June 2002 were included in the analysis since HER2/neu was only routinely assessed beginning with the 1998 follow-up cycle. Results: 211 HER2/neu positive and 770 HER2/neu negative cases were included in the analysis. In this predominantly postmenopausal group aged 52–77 in 1998, HER2neu negative cancers were more likely to be ER+/PR+ (72%) and less likely to be ER-/PR- (11%) than HER2/neu positive ones (58% ER+/PR+ and 24% ER-/PR-), but the majority of cancers were still ER+/PR+. In multivariate models, risk factor associations by HER2/neu status were similar with positive associations seen for family history, benign breast disease, body mass index, current postmenopausal hormone use, and cumulative alcohol consumption. However, when the subgroup of ER-/PR-/HER2/neu negative cancers were evaluated separately (N=83), most of these risk factor associations disappeared with the only significant risk factor being a prior history of benign breast disease. Conclusions: This is the first prospective data study to report on risk factor association by HER2/neu status. For the standard epidemiologic breast cancer risk factors, ER and PR status appear to better represent separate etiologic pathways, rather than HER2/neu status. However, the subgroup of ER/PR/HER2neu negative breast cancers appears to be distinct, although power was limited and HER2/neu status was not confirmed by central review. Additional analyses stratified by ER/PR status will also be presented. No significant financial relationships to disclose.

Predicting risk of estrogen receptor positive breast cancers in postmenopausal women

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 1507-1507
Author(s):  
R. T. Chlebowski ◽  
G. L. Anderson ◽  
D. S. Lane ◽  
A. Aragaki ◽  
T. Rohan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Estrogen Receptor ◽  
Family History ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Postmenopausal Women ◽  
Breast Biopsy ◽  
Breast Cancers ◽  
Estrogen Receptor Positive

1507 Background: Chemoprevention strategies for estrogen receptor positive (ER+) breast cancers are emerging, especially for postmenopausal women, but require methods of targeting appropriate populations. Our objective was to improve the Breast Cancer Risk Assessment Tool [Gail Model (GM)] for estimating ER+ breast cancer risk. Methods: A prospective cohort involving 161,809 postmenopausal women aged 50–79 years, (93,676 in the observational study (OS) and 68,132 in clinical trials (CT)) at Women’s Health Initiative (WHI) Clinical Centers had comprehensive assessment of lifestyle, medication use and breast cancer risk factors. Breast cancer risk from the GM and other models incorporating additional or fewer risk factors and five year incidence of ER + and ER negative (ER-) invasive breast cancers were determined. Main outcome measures were concordance statistics for models predicting breast cancer risk. Results: Of 148,266 women meeting eligibility criteria, (no prior breast cancer and/or mastectomy), 3,236 developed breast cancer. Chronological age and age at menopause, both GM components, were significantly associated with only ER+ but not ER- breast cancer risk (p<0.05 for heterogeneity test). The GM predicted population-based ER+ cancer risk with reasonable accuracy (concordance statistic 0.60, 95% confidence interval (CI) 0.58 to 0.62) but for ER- cancers, the results were equivalent to chance allocation (concordance statistic 0.49, 95% CI 0.45 to 0.54). For ER+ cancers, no additional risk factors improved the GM prediction. However, a simpler model, developed in the OS and tested in the CT population, including only age, family history, and benign breast biopsy was comparable to GM in ER+ breast cancer prediction (concordance statistics 0.58, 95% CI 0.56 to 0.60). Using this model, all women ≥ 55 years old (or ≥ 60 year old if African American) with either a prior breast biopsy or first degree breast cancer family history had five year breast cancer risk of ≥ 1.8%. Conclusions: In postmenopausal women with comprehensive mammography use, the GM identifies populations at increased risk for ER+ breast cancer but not for ER- cancer. A model with fewer variables provides a simpler alternative for identifying populations appropriate for breast cancer chemoprevention interventions. No significant financial relationships to disclose.

scholarly journals Low-risk factor profile, estrogen levels, and breast cancer risk among postmenopausal women

2009 ◽  
Vol 124 (8) ◽  
pp. 1935-1940 ◽  
Author(s):  
Naja Hulvej Rod ◽  
Åse Marie Hansen ◽  
Jens Nielsen ◽  
Peter Schnohr ◽  
Morten Grønbaek
Keyword(s):  
Breast Cancer ◽  
Risk Factor ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Postmenopausal Women ◽  
Low Risk ◽  
Risk Factor Profile

Use of Bisphosphonates and Risk of Breast Cancer in a French Cohort of Postmenopausal Women

2017 ◽  
Vol 35 (28) ◽  
pp. 3230-3239 ◽  
Author(s):  
Agnès Fournier ◽  
Sylvie Mesrine ◽  
Amandine Gelot ◽  
Guy Fagherazzi ◽  
Laura Baglietto ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Postmenopausal Women ◽  
Cancer Incidence ◽  
Hormone Replacement ◽  
Breast Cancer Incidence ◽  
Mineral Density

Purpose To assess whether bisphosphonate (BP) use is associated with decreased breast cancer incidence in a cohort of postmenopausal women. Methods The study population included 64,438 postmenopausal women participating in the French E3N (Etude Epidémiologique auprès de femmes de la Mutuelle Générale de l'Education Nationale) prospective cohort, with data self-reported in biennial questionnaires matched with data from a drug reimbursement database. Exposure to BPs and the use of other osteoporosis treatments during follow-up were determined using reimbursement data. Other covariates (breast cancer risk factors, clinical risk factors for osteoporotic fractures, and bone mineral density surveillance) originated from the questionnaires. Hazard ratios (HRs) of breast cancer were estimated using Cox proportional hazards models, considering exposure as a time-varying variable. Results Over an average of 7.2 years of follow-up (2004 to 2011), 2,407 first primary breast cancer cases were identified. The HR of breast cancer associated with exposure to BPs was 0.98 (95% CI, 0.85 to 1.12). We found no effect modification by age, body mass index, time since menopause, use of hormone replacement therapy, use of calcium supplements, or use of vitamin D supplements. There was no heterogeneity across BP molecules and no trend according to cumulative dose, duration of use, or time since last use. We observed a decrease in breast cancer risk restricted to the year after treatment initiation (HR, 0.56; 95% CI, 0.36 to 0.87), which was likely explained by healthy screenee bias. Finally, we did not find any variation in HRs across breast carcinomas defined by their estrogen receptor or invasive or in situ status. Conclusion In our observational cohort of postmenopausal women observed from 2004 to 2011, BP use, likely prescribed for the management of osteoporosis, was not associated with decreased breast cancer incidence.

scholarly journals Update on the importance of parenchymal patterns and breast cancer risk

2004 ◽  
Vol 7 (12) ◽  
Author(s):  
J. Ding ◽  
R. Warren
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Risk Factor ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Mammographic Density ◽  
Cancer Diagnosis ◽  
Independent Risk Factor ◽  
Risk Assessments ◽  
Quantitative Assessments

Mammographic density is a well-documented independent risk factor for breast cancer. Measurements of density come in various forms, ranging from qualitative descriptions to quantitative assessments or a combination of both. The different means of examining density lead to variations in density–risk relationship. Currently there is no consensus on which method is preferable. The interrelation of mammographic density with other risk factors is crucial to density–risk assessments, since each of these risk factors can influence density on its own. Mammographic density can be modified through hormonal and chemical means, which can have important implications on mammographic sensitivity, accuracy in cancer diagnosis and cancer prevention.

scholarly journals Awareness of breast cancer risk factors and practices of breast self-examination among North Indian unmarried females

2021 ◽  
Vol 8 (4) ◽  
pp. 1721
Author(s):  
Kavita . ◽  
Damanpreet Kaur ◽  
Jarnail Singh Thakur ◽  
Darshna . ◽  
Pushplata . ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Risk Factor ◽  
Breast Cancer Risk ◽  
Early Detection ◽  
Cancer Risk ◽  
Breast Self Examination ◽  
Cancer Risk Factors ◽  
Breast Cancer Risk Factors ◽  
Self Examination

Background: Breast cancer is a leading health problem in females in developing countries. It is associated with various risk factors which are largely preventable. Risk factor awareness and adherence to healthy life style can play a significant role in prevention of cancer. So, study was undertaken to assess the awareness of risk factor of breast cancer and practices of breast self-examination among unmarried females.Methods:  A descriptive cross sectional study design was adopted to recruit 150 subjects. Purposive sampling technique was used to enrol unmarried females above 19 years of age. Written informed consent was taken from participants. Interview schedule was constructed, validated and used for data collection. The data was analysed using SPSS version 20.0.Results: Findings of the study revealed that mean age of participant was 22.65±3.21 years. Most of the females were aware that non breast-feeding practices (94.7%), infertility (84.7%), using oral contraceptives pills (50.7%), advancing age (48%), and any trauma to breast (36.7%) are risk factors of breast cancer. Nearly three fourth (76%) of the subjects had good awareness of breast cancer risk factors. However, breast self-examination was only practiced by 14.6% (22) subjects from total 150 subjects.Conclusions: Study concluded that most of the women were aware about the risk factors of breast cancer, however only few were practicing breast self-examination. Since screening and early detection of breast cancer is crucial for cancer control, nurses as health professionals have a significant role to play in early detection and increasing awareness among individuals and communities. 

scholarly journals Asymmetric Dense Breast is an Independent Breast Cancer Risk Factor

2021 ◽  
Vol 8 (2) ◽  
Author(s):  
Alikhassi A ◽  
◽  
Shariatalavi R ◽  
Moradi B ◽  
◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Risk Factor ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Breast Cancer Risk Factor ◽  
Control Group ◽  
Control Groups ◽  
Cancer Risk Factor ◽  
And Control

Objectives: There are multiple known breast cancer risk factors, but most women with breast cancer do not have any of them, so there should be some other unknown risk factors. We hypothesized that asymmetric breast densities could be another breast cancer risk factor. Method: In this study, we defined two case and control groups with 136 women with breast cancer and 136 who did not have breast cancer, respectively. Any different type of asymmetry in either breast was recorded in both groups. Result: The frequency of focal asymmetry in cases was 47 (34.6%), which was statistically more significant than in the control group (28 (20.6%)) (p=0.010). There were three (2.9%) and five (3.7%) global asymmetries in the case and control groups, respectively (p=0.735). The frequency of one view asymmetry in the case and control groups was not significant (16 (11.8%) and 9 (6.6%) respectively) (p=0.142). In the case group, 59 (43.4%) women had at least one type of asymmetry, compared to 41 (30.1%) in the control group (p=0.02). We identify focal asymmetries (likelihood ratio, 1.215; p=0.027) is risk factors for breast cancer. Conclusion: Breast density asymmetry is a breast cancer risk factor that could be scored, thus enhancing risk stratification for screening and prevention.

Associations of established breast cancer risk factors with urinary estrogens in postmenopausal women

2022 ◽  
Author(s):  
Lusine Yaghjyan ◽  
Lancia N. F. Darville ◽  
Jayden Cline ◽  
Yessica C. Martinez ◽  
Shannan Rich ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Postmenopausal Women ◽  
Cancer Risk Factors ◽  
Breast Cancer Risk Factors ◽  
Urinary Estrogens
Sign in / Sign up

Export Citation Format

Share Document