scholarly journals Correction to: High‑Resolution Colonic Manometry Pressure Profiles Are Similar in Asymptomatic Diverticulosis and Controls

2020 ◽  
Author(s):  
Rebekah Jaung ◽  
Chris Varghese ◽  
Anthony Y. Lin ◽  
Niranchan Paskaranandavadivel ◽  
Peng Du ◽  
...  
Keyword(s):  
High Resolution ◽  
Colonic Manometry ◽  
Pressure Profiles

High-Resolution Colonic Manometry Pressure Profiles Are Similar in Asymptomatic Diverticulosis and Controls

2020 ◽  
Author(s):  
Rebekah Jaung ◽  
Chris Varghese ◽  
Anthony Y. Lin ◽  
Niranchan Paskaranandavadivel ◽  
Peng Du ◽  
...  
Keyword(s):  
High Resolution ◽  
Colonic Manometry ◽  
Pressure Profiles

scholarly journals A35 ASSOCIATIONS BETWEEN AUTONOMIC DYSFUNCTION, COLONIC DYSMOTILITY AND ABSENT DEFECATION REFLEXES IN PATIENTS WITH CHRONIC REFRACTORY CONSTIPATION

2021 ◽  
Vol 4 (Supplement_1) ◽  
pp. 276-278
Author(s):  
L Liu ◽  
N Milkova ◽  
M Ali ◽  
K Sharma ◽  
J D Huizinga ◽  
...  
Keyword(s):  
Nervous System ◽  
Autonomic Nervous System ◽  
High Resolution ◽  
Autonomic Dysfunction ◽  
Sympathetic Tone ◽  
Stress Index ◽  
Autonomic Reactivity ◽  
Autonomic Tone ◽  
Autonomic Nervous ◽  
Colonic Manometry

Abstract Background A defecation reflex involves sensory information from the colon sent to the central nervous system which results in propulsive motor patterns in the colon through programmed neural activity from the autonomic nervous system. Neurological causes of constipation are recognized but specific neurological pathways that contribute to pathophysiology of the disease is underexplored. Diagnosis and treatment usually do not involve the autonomic nervous system. Aims Our objective was to assess autonomic dysfunction and abnormal defecation reflexes as a possible cause of chronic constipation. Methods Defecation reflexes were assessed by high-resolution colonic manometry through balloon distention, meal intake, and rectal bisacodyl. Specific heart rate variability (HRV) parameters were used to assess general orthostatic autonomic reactivity, and autonomic functioning during high resolution colonic manometry, in 14 patients with chronic refractory constipation considered for surgery. Results All patients had a unique combination of motility, reflex ability and HRV profiles. Patients overall did not generate HAPWs or had lower HAPW amplitude and lower propulsive activity compared to healthy individuals. Half of the 14 patients were tested to have high sympathetic tone based on Baevsky’s stress index prior to HRCM, and 11 of the patients had sympathetic hyper-reactivity and/or low parasympathetic reactivity to at least one type of colonic stimulation during HRCM. Abnormal autonomic tone or autonomic reactivity to colonic stimulation was present in all four patients with absence of the vagosacral defecation reflex. Five of the seven patients with absence of the sacral defecation reflex showed high sympathetic tone or high sympathetic reactivity to stimulation. Only two patients had abnormality in coloanal coordination and this was associated with low parasympathetic reactivity to stimulation in both patients. Conclusions The assumption that colonic resection was needed to remove an inert colon was wrong in most patients, but most patients had some form of reflex abnormality. Sympathetic dominance far outweighed parasympathetic dysfunction. Incorporation of assessments of defecation reflexes and autonomic nervous system activity into diagnosis of chronic refractory constipation provides a comprehensive pathophysiological understanding of specific defective neurological pathways contributing to dysmotility. This forms the basis for our individualized treatment efforts through sacral neuromodulation. Funding Agencies CIHR

scholarly journals The Defecation Reflex Assessed by High-Resolution Colonic Manometry

2020 ◽  
Author(s):  
Ji-Hong Chen ◽  
Natalija Milkova ◽  
Lijun Liu ◽  
Jan D Huizinga
Keyword(s):  
High Resolution ◽  
Colonic Manometry

scholarly journals A288 ANAL SPHINCTER RELAXATION ASSOCIATED WITH THE DEFECATION REFLEX AND GAS EXPULSION, ASSESSED BY HIGH-RESOLUTION COLONIC MANOMETRY

2018 ◽  
Vol 1 (suppl_2) ◽  
pp. 415-416
Author(s):  
J Chen ◽  
M Shokrollahi ◽  
E Ratcliffe ◽  
D Armstrong ◽  
S P Parsons ◽  
...  
Keyword(s):  
High Resolution ◽  
Anal Sphincter ◽  
Colonic Manometry

837 The Spatiotemporal Characteristics of Retrograde Motor Activity in the Distal Colon Defined by High-Resolution Colonic Manometry

2016 ◽  
Vol 150 (4) ◽  
pp. S177 ◽  
Author(s):  
Anthony Y. Lin ◽  
Peng Du ◽  
Jozef Kamp ◽  
Leo K. Cheng ◽  
Philip Dinning ◽  
...  
Keyword(s):  
High Resolution ◽  
Motor Activity ◽  
Distal Colon ◽  
Spatiotemporal Characteristics ◽  
Colonic Manometry

Development and feasibility of an ambulatory acquisition system for fiber‐optic high‐resolution colonic manometry

2019 ◽  
Vol 31 (12) ◽  
Author(s):  
Cameron I. Wells ◽  
Nira Paskaranandavadivel ◽  
Anthony Y. Lin ◽  
Peng Du ◽  
James A. Penfold ◽  
...  
Keyword(s):  
High Resolution ◽  
Fiber Optic ◽  
Acquisition System ◽  
Colonic Manometry

scholarly journals Iterative maximum a posteriori (IMAP)-DOAS for retrieval of strongly absorbing trace gases: Model studies for CH<sub>4</sub> and CO<sub>2</sub> retrieval from near infrared spectra of SCIAMACHY onboard ENVISAT

2005 ◽  
Vol 5 (1) ◽  
pp. 9-22 ◽  
Author(s):  
C. Frankenberg ◽  
U. Platt ◽  
T. Wagner
Keyword(s):  
High Resolution ◽  
Spectral Region ◽  
Near Infrared ◽  
Absorption Lines ◽  
Optical Absorption Spectroscopy ◽  
Maximum A Posteriori ◽  
Special Importance ◽  
A Posteriori ◽  
Pressure Profiles ◽  
Temperature And Pressure

Abstract. In the past, differential optical absorption spectroscopy (DOAS) has mostly been employed for atmospheric trace gas retrieval in the UV/Vis spectral region. New spectrometers such as SCIAMACHY onboard ENVISAT also provide near infrared channels and thus allow for the detection of greenhouse gases like CH4, CO2, or N2O. However, modifications of the classical DOAS algorithm are necessary to account for the idiosyncrasies of this spectral region, i.e. the temperature and pressure dependence of the high resolution absorption lines. Furthermore, understanding the sensitivity of the measurement of these high resolution, strong absorption lines by means of a non-ideal device, i.e. having finite spectral resolution, is of special importance. This applies not only in the NIR, but can also prove to be an issue for the UV/Vis spectral region. This paper presents a modified iterative maximum a posteriori-DOAS (IMAP-DOAS) algorithm based on optimal estimation theory introduced to the remote sensing community by rodgers76. This method directly iterates the vertical column densities of the absorbers of interest until the modeled total optical density fits the measurement. Although the discussion in this paper lays emphasis on satellite retrieval, the basic principles of the algorithm also hold for arbitrary measurement geometries. This new approach is applied to modeled spectra based on a comprehensive set of atmospheric temperature and pressure profiles. This analysis reveals that the sensitivity of measurement strongly depends on the prevailing pressure-height. The IMAP-DOAS algorithm properly accounts for the sensitivity of measurement on pressure due to pressure broadening of the absorption lines. Thus, biases in the retrieved vertical columns that would arise in classical algorithms, are obviated. Here, we analyse and quantify these systematic biases as well as errors due to variations in the temperature and pressure profiles, which is indispensable for the understanding of measurement precision and accuracy in the near infrared as well as for future intercomparisons of retrieval algorithms.

scholarly journals Su1644 – Interobserver Analysis Trial on Colonic Motor Pattern Recognition for High-Resolution Colonic Manometry

2019 ◽  
Vol 156 (6) ◽  
pp. S-595
Author(s):  
Jasper Pannemans ◽  
Tim Vanuytsel ◽  
Ans Pauwels ◽  
Nathalie Rommel ◽  
Heiko U. De Schepper ◽  
...  
Keyword(s):  
Pattern Recognition ◽  
High Resolution ◽  
Motor Pattern ◽  
Colonic Manometry ◽  
Colonic Motor
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