scholarly journals Biophysical mechanism of the interaction between default mode network and working memory network

2021 ◽  
Author(s):  
Yue Yuan ◽  
Xiaochuan Pan ◽  
Rubin Wang
Keyword(s):  
Working Memory ◽  
Neural Activity ◽  
Default Mode Network ◽  
Phase Synchronization ◽  
Memory Task ◽  
Inhibitory Neurons ◽  
Default Mode ◽  
Functional Connections ◽  
Functional Brain Network ◽  
Memory Network

AbstractDefault mode network (DMN) is a functional brain network with a unique neural activity pattern that shows high activity in resting states but low activity in task states. This unique pattern has been proved to relate with higher cognitions such as learning, memory and decision-making. But neural mechanisms of interactions between the default network and the task-related network are still poorly understood. In this paper, a theoretical model of coupling the DMN and working memory network (WMN) is proposed. The WMN and DMN both consist of excitatory and inhibitory neurons connected by AMPA, NMDA, GABA synapses, and are coupled with each other only by excitatory synapses. This model is implemented to demonstrate dynamical processes in a working memory task containing encoding, maintenance and retrieval phases. Simulated results have shown that: (1) AMPA channels could produce significant synchronous oscillations in population neurons, which is beneficial to change oscillation patterns in the WMN and DMN. (2) Different NMDA conductance between the networks could generate multiple neural activity modes in the whole network, which may be an important mechanism to switch states of the networks between three different phases of working memory. (3) The number of sequentially memorized stimuli was related to the energy consumption determined by the network's internal parameters, and the DMN contributed to a more stable working memory process. (4) Finally, this model demonstrated that, in three phases of working memory, different memory phases corresponded to different functional connections between the DMN and WMN. Coupling strengths that measured these functional connections differed in terms of phase synchronization. Phase synchronization characteristics of the contained energy were consistent with the observations of negative and positive correlations between the WMN and DMN reported in referenced fMRI experiments. The results suggested that the coupled interaction between the WMN and DMN played important roles in working memory.

scholarly journals The Default Mode Network and the Working Memory Network Are Not Anti-Correlated during All Phases of a Working Memory Task

PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0123354 ◽  
Author(s):  
Tommaso Piccoli ◽  
Giancarlo Valente ◽  
David E. J. Linden ◽  
Marta Re ◽  
Fabrizio Esposito ◽  
...  
Keyword(s):  
Working Memory ◽  
Default Mode Network ◽  
Memory Task ◽  
Default Mode ◽  
Memory Network

scholarly journals Coactivation of the Default Mode Network regions and Working Memory Network regions during task preparation

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Hideya Koshino ◽  
Takehiro Minamoto ◽  
Ken Yaoi ◽  
Mariko Osaka ◽  
Naoyuki Osaka
Keyword(s):  
Working Memory ◽  
Default Mode Network ◽  
Default Mode ◽  
Task Preparation ◽  
Memory Network

Failure to deactivate in the prefrontal cortex in schizophrenia: dysfunction of the default mode network?

2008 ◽  
Vol 38 (8) ◽  
pp. 1185-1193 ◽  
Author(s):  
E. Pomarol-Clotet ◽  
R. Salvador ◽  
S. Sarró ◽  
J. Gomar ◽  
F. Vila ◽  
...  
Keyword(s):  
Working Memory ◽  
Prefrontal Cortex ◽  
Default Mode Network ◽  
Sense Of Self ◽  
Memory Task ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Default Mode ◽  
Schizophrenic Patients ◽  
Back Task

BackgroundFunctional imaging studies using working memory tasks have documented both prefrontal cortex (PFC) hypo- and hyperactivation in schizophrenia. However, these studies have often failed to consider the potential role of task-related deactivation.MethodThirty-two patients with chronic schizophrenia and 32 age- and sex-matched normal controls underwent functional magnetic resonance imaging (fMRI) scanning while performing baseline, 1-back and 2-back versions of the n-back task. Linear models were used to obtain maps of activations and deactivations in the groups.ResultsThe controls showed activation in the expected frontal regions. There were also clusters of deactivation, particularly in the anterior cingulate/ventromedial PFC and the posterior cingulate cortex/precuneus. Compared to the controls, the schizophrenic patients showed reduced activation in the right dorsolateral prefrontal cortex (DLPFC) and other frontal areas. There was also an area in the anterior cingulate/ventromedial PFC where the patients showed apparently greater activation than the controls. This represented a failure of deactivation in the schizophrenic patients. Failure to activate was a function of the patients' impaired performance on the n-back task, whereas the failure to deactivate was less performance dependent.ConclusionsPatients with schizophrenia show both failure to activate and failure to deactivate during performance of a working memory task. The area of failure of deactivation is in the anterior prefrontal/anterior cingulate cortex and corresponds to one of the two midline components of the ‘default mode network’ implicated in functions related to maintaining one's sense of self.

scholarly journals Is a Responsive Default Mode Network Required for Successful Working Memory Task Performance?

2015 ◽  
Vol 35 (33) ◽  
pp. 11595-11605 ◽  
Author(s):  
Marta Čeko ◽  
John L. Gracely ◽  
Mary-Ann Fitzcharles ◽  
David A. Seminowicz ◽  
Petra Schweinhardt ◽  
...  
Keyword(s):  
Working Memory ◽  
Task Performance ◽  
Default Mode Network ◽  
Memory Task ◽  
Default Mode

scholarly journals Reduced default mode network suppression during a working memory task in remitted major depression

2015 ◽  
Vol 64 ◽  
pp. 9-18 ◽  
Author(s):  
Lucie Bartova ◽  
Bernhard M. Meyer ◽  
Kersten Diers ◽  
Ulrich Rabl ◽  
Christian Scharinger ◽  
...  
Keyword(s):  
Working Memory ◽  
Major Depression ◽  
Default Mode Network ◽  
Memory Task ◽  
Default Mode

scholarly journals Default mode network deactivation in pediatric temporal lobe epilepsy: Relationship to a working memory task and executive function tests

2019 ◽  
Vol 94 ◽  
pp. 124-130 ◽  
Author(s):  
Temitayo O. Oyegbile ◽  
John W. VanMeter ◽  
Gholam K. Motamedi ◽  
William L. Bell ◽  
William D. Gaillard ◽  
...  
Keyword(s):  
Working Memory ◽  
Executive Function ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Default Mode Network ◽  
Memory Task ◽  
Default Mode ◽  
Function Tests

scholarly journals Default mode network can support the level of detail in experience during active task states

2018 ◽  
Vol 115 (37) ◽  
pp. 9318-9323 ◽  
Author(s):  
Mladen Sormaz ◽  
Charlotte Murphy ◽  
Hao-ting Wang ◽  
Mark Hymers ◽  
Theodoros Karapanagiotidis ◽  
...  
Keyword(s):  
Working Memory ◽  
Neural Activity ◽  
Default Mode Network ◽  
Memory Load ◽  
Premotor Cortex ◽  
Self Report ◽  
Default Mode ◽  
Report Data ◽  
Self Report Data ◽  
Task Conditions

Regions of transmodal cortex, in particular the default mode network (DMN), have historically been argued to serve functions unrelated to task performance, in part because of associations with naturally occurring periods of off-task thought. In contrast, contemporary views of the DMN suggest it plays an integrative role in cognition that emerges from its location at the top of a cortical hierarchy and its relative isolation from systems directly involved in perception and action. The combination of these topographical features may allow the DMN to support abstract representations derived from lower levels in the hierarchy and so reflect the broader cognitive landscape. To investigate these contrasting views of DMN function, we sampled experience as participants performed tasks varying in their working-memory load while inside an fMRI scanner. We used self-report data to establish dimensions of thought that describe levels of detail, the relationship to a task, the modality of thought, and its emotional qualities. We used representational similarity analysis to examine correspondences between patterns of neural activity and each dimension of thought. Our results were inconsistent with a task-negative view of DMN function. Distinctions between on- and off-task thought were associated with patterns of consistent neural activity in regions adjacent to unimodal cortex, including motor and premotor cortex. Detail in ongoing thought was associated with patterns of activity within the DMN during periods of working-memory maintenance. These results demonstrate a contribution of the DMN to ongoing cognition extending beyond task-unrelated processing that can include detailed experiences occurring under active task conditions.

scholarly journals Long-term stress and trait anxiety alter brain network balance in dynamic decisions during working memory

2021 ◽  
Author(s):  
Liangying Liu ◽  
Jianhu Wu ◽  
Haiyang Geng ◽  
Chao Liu ◽  
Yuejia Luo ◽  
...  
Keyword(s):  
Working Memory ◽  
Trait Anxiety ◽  
Default Mode Network ◽  
Brain Network ◽  
Decision Threshold ◽  
Default Mode ◽  
Evidence Accumulation ◽  
Functional Brain Network ◽  
Dynamic Decisions

Long-term stress has a profound impact on the human brain and cognition, and trait anxiety influences stress-induced adaptive and maladaptive effects. However, the neurocognitive mechanisms underlying long-term stress and trait anxiety interactions remain elusive. Here we investigated how long-term stress and trait anxiety interact to affect dynamic decisions during working-memory (WM) by altering functional brain network balance. In comparison to controls, male participants under long-term stress experienced higher psychological distress and exhibited faster evidence accumulation but had a lower decision-threshold during WM. This corresponded with hyper-activation in the anterior insula, less WM-related deactivation in the default-mode network, and stronger default-mode network decoupling with the frontoparietal network. Critically, high trait anxiety under long-term stress led to slower evidence accumulation through higher WM-related frontoparietal activity, and increased decoupling between the default-mode and frontoparietal networks. Our findings provide neurocognitive evidence for long-term stress and trait anxiety interactions on executive functions with (mal)adaptive changes.

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