Optical cavity structure design and optical path simulation for rapid nitric oxide detection

2021 ◽  
Vol 17 (12) ◽  
pp. 757-762
Author(s):  
Wen Li ◽  
Yongqing Cai ◽  
Mengfan Chen ◽  
Peng Liu
Keyword(s):  
Nitric Oxide ◽  
Optical Cavity ◽  
Structure Design ◽  
Optical Path ◽  
Cavity Structure

scholarly journals Demonstration of a Label-Free and Low-Cost Optical Cavity-Based Biosensor Using Streptavidin and C-Reactive Protein

Biosensors ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 4
Author(s):  
Donggee Rho ◽  
Seunghyun Kim
Keyword(s):  
Limit Of Detection ◽  
Point Of Care ◽  
Low Cost ◽  
Optical Cavity ◽  
Sample Volume ◽  
Small Sample ◽  
Label Free ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Cavity Structure

An optical cavity-based biosensor (OCB) has been developed for point-of-care (POC) applications. This label-free biosensor employs low-cost components and simple fabrication processes to lower the overall cost while achieving high sensitivity using a differential detection method. To experimentally demonstrate its limit of detection (LOD), we conducted biosensing experiments with streptavidin and C-reactive protein (CRP). The optical cavity structure was optimized further for better sensitivity and easier fluid control. We utilized the polymer swelling property to fine-tune the optical cavity width, which significantly improved the success rate to produce measurable samples. Four different concentrations of streptavidin were tested in triplicate, and the LOD of the OCB was determined to be 1.35 nM. The OCB also successfully detected three different concentrations of human CRP using biotinylated CRP antibody. The LOD for CRP detection was 377 pM. All measurements were done using a small sample volume of 15 µL within 30 min. By reducing the sensing area, improving the functionalization and passivation processes, and increasing the sample volume, the LOD of the OCB are estimated to be reduced further to the femto-molar range. Overall, the demonstrated capability of the OCB in the present work shows great potential to be used as a promising POC biosensor.

High Refractive-Index Microspheres as Optical Cavity Structure

2004 ◽  
Vol 32 (1-3) ◽  
pp. 189-194 ◽  
Author(s):  
Yusuke Arai ◽  
Tetsuji Yano ◽  
Shuichi Shibata
Keyword(s):  
Refractive Index ◽  
Optical Cavity ◽  
High Refractive Index ◽  
Cavity Structure

Channeled Twin-Ridge Substrate Three-Segmented Large Optical Cavity Structure GaAlAs/GaAs Laser

1987 ◽  
Author(s):  
Yudong Li ◽  
Donghai Zhu ◽  
Shiyong Liu ◽  
Dingsan Gao
Keyword(s):  
Optical Cavity ◽  
Cavity Structure ◽  
Gaas Laser

Laser Transmission Technology of Laser Additive Manufacturing

2013 ◽  
Vol 380-384 ◽  
pp. 4315-4318
Author(s):  
Kai Zhang ◽  
Xiao Feng Shang ◽  
Lei Wang
Keyword(s):  
Additive Manufacturing ◽  
Manufacturing Process ◽  
Laser Power ◽  
Structure Design ◽  
Optical Path ◽  
Metal Component ◽  
Laser Additive Manufacturing ◽  
Generator System ◽  
Additive Manufacturing Technology ◽  
And Function

The laser additive manufacturing technology is a laser assisted direct metal manufacturing process. This process offers the ability to make a metal component directly from CAD drawings. The manufacturing equipment consists of some components. Among them, the laser transmission component plays an important role in the whole fabricating process. It provides the energy source to melt the metal powder, so it is necessary to develop the laser transmission technology. This technology is achieved primarily by laser generator system and optical path transmission system. The related structure design and function implementation prove that the laser transmission technology can generate desirable laser power at precise assigned position, and complete the manufacturing process with flying colors.

A compact asymmetric chaotic optical cavity with long optical path lengths

2008 ◽  
Vol 93 (1) ◽  
pp. 014101 ◽  
Author(s):  
Dongxia Qu ◽  
Zhijun Liu ◽  
Claire Gmachl
Keyword(s):  
Optical Cavity ◽  
Optical Path ◽  
Path Lengths

Porous silicon optical cavity structure applied to high sensitivity organic solvent sensor

2008 ◽  
Vol 39 (3-4) ◽  
pp. 499-506 ◽  
Author(s):  
Danilo R. Huanca ◽  
Francisco J. Ramirez-Fernandez ◽  
Walter J. Salcedo
Keyword(s):  
Porous Silicon ◽  
Organic Solvent ◽  
Optical Cavity ◽  
High Sensitivity ◽  
Cavity Structure

scholarly journals Dye-doped spherical particles of optical cavity structure

1997 ◽  
Author(s):  
Shuichi Shibata ◽  
Tetsuji Yano ◽  
Masayuki Yamane
Keyword(s):  
Optical Cavity ◽  
Spherical Particles ◽  
Cavity Structure

Opto-Mechanical Structure Design of the Image Stabilization Collimator

2013 ◽  
Vol 552 ◽  
pp. 79-84
Author(s):  
Yang Zheng ◽  
Yue Gang Fu ◽  
Wen Jun He ◽  
Jia Ke Wang ◽  
Lei Zhang
Keyword(s):  
Mathematical Modeling ◽  
Human Disturbance ◽  
Liquid Surface ◽  
Structure Design ◽  
Optical Path ◽  
Dynamic Imaging ◽  
Image Stabilization ◽  
Modeling And Analysis ◽  
New Type ◽  
Micro Vibration

The collimator has an extensive application as an experiment equipment that can provide an infinity goal in the instrument alignment and testing.This paper provides a new type of collimator with image stabilization function in consideration of human disturbance factors, including environment micro-vibration and so on. Liquid surface which appears natural level under gravity imaging optical path of collimator can emerge through liquid refraction and reflex later. And we should make use of this phenomenon. Mathematical modeling and analysis on the principle of dynamic imaging of the liquid wedge have been made to design several optical principle charts of the collimator with image stabilization function.One of the image stabilization optical principle structure styles has been designed based on its mechanical structure.An experiment prototype is produced and is made more practical.

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