Cyclodextrin-Containing Hydrogels: A Review of Preparation Method, Drug Delivery, and Degradation Behavior

Hydrogels possess porous structures, which are widely applied in the field of materials and biomedicine. As a natural oligosaccharide, cyclodextrin (CD) has shown remarkable application prospects in the synthesis and utilization of hydrogels. CD can be incorporated into hydrogels to form chemically or physically cross-linked networks. Furthermore, the unique cavity structure of CD makes it an ideal vehicle for the delivery of active ingredients into target tissues. This review describes useful methods to prepare CD-containing hydrogels. In addition, the potential biomedical applications of CD-containing hydrogels are reviewed. The release and degradation process of CD-containing hydrogels under different conditions are discussed. Finally, the current challenges and future research directions on CD-containing hydrogels are presented.

Adsorption Performance of Human-like Collagen by Alkali-modified Kapok Fiber: A Kinetic, Equilibrium, and Mechanistic Investigation

Collagen-based dressings achieve excellent repair of the skin during metical cosmetology, which has received a lot of attention recently. Although great progress has been made on using biomass fiber as dressing carrier, more research is required on developing novel biomass fibers because of the limitations of (i.e., high cost and complex processing) of existing materials. In this study, the adsorption behaviors of two human-like collagen were studied by examining the Kapok fiber that was modified using alkali consisting of various amounts of the mass fraction. Results show that the alkali-modified Kapok fiber surface becomes rough with vertically arranged grooves, and the cross-section depicts the hollow cavity structure. The composition analysis of alkali modified Kapok shows that alkali dissolves part of the hemicellulose and lignin. Additionally, the surface energy rises sharply and the water contact angle changed from hydrophobic to hydrophilic. The adsorption amount of raw Kapok fiber is around 0.6g/g, which accounts for only one twenty-first of the adsorption amount of alkali-treated Kapok (around 12.6g/g), while the equilibrium adsorption amount was not sensitive to alkali concentration. The kinetics of human-like collagen followed both Quasi first and Quasi second order kinetic model, implying that the adsorption process where characterized by both physisorption and chemisorption. Finally, characterization of the AKF-2 coupled with the studies based on the inter-particle diffusion model showed a three-step of human-like collagen diffusion consisting of surface diffusion, inter-fiber diffusion and fiber' hollow cavity diffusion. Our results demonstrate a perfect high absorption performance of Kapok fiber providing a potential for application of collagen-base dressings.

Modulation and optimization of terahertz absorption in micro-cavity quantum well structures by graphene grating

Metal-insulator-metal (MIM)-based plasmonic microcavity has attracted widespread interest due to its ability in manipulating and concentrating photons on the sub-wavelength scale. However, noble metals suffer from large intrinsic loss and lack active tunability. Here, a micro-cavity structure of quantum well sandwiched between periodic top contact of graphene grating and bottom contact graphene was proposed. Graphene plasmons provide a suitable alternative for metal plasmons and provide the advantage of being highly tunable by electrostatic gating. Effect of changes in both graphene physical and device structural parameters on optimized absorption performance was systematically analyzed through the calculation of reflectivity curves of incident light. Our results indicate that intersubband absorption of device can be improved by adjusting parameters of both graphene material and device structure. Furthermore, cavity resonant mode excited by surface plasmon polariton can be tuned to response frequency of quantum well under optimized parameters. Intersubband absorption is almost 1.5 times higher than that of a micro-cavity structure that uses metal grating.

The computational analyses, molecular dynamics of fatty-acid transport mechanism to the CD36 receptor

The transmembrane glycoprotein CD36, which is responsible of the metabolic disorders, and the elevated intake of fat induces lipid buildup, is a multifunctional scavenger receptor signaling those functions in high-affinity tissue uptake of long-chain fatty acids. In this study, we used series of molecular dynamics simulations of the wild type and mutants types K164A CD36 protein interacting with one palmitic acid (PLM) besides simulations of the wild type interacting with the three PLM to find out the mechanism of the functioning of the complex CD36/Fatty acids and the unraveling of the role of the mutation. Additionally we determined whether Lys164, mostly exposed to protein surface, played important roles in fatty acid uptake. These simulations revealed, the conformational changes induced by Lys164 residue and the altered interactions induced by the mutagenesis of surface lysine that was badly influencing the folding, utility, solubility, and stability form of the variant. Furthermore, Lys164 residue provided the structural basis of forming an opening at the region of principal portal for the dissociation of palmitic acid. The results of our simulations revealed hole two fatty acids found in CD36 cavity structure and it was the most preferred to CD36 structure stabilization.

Design of A Ka-Band 3D-Printed Dual-Polarization Magnetoelectric Dipole Antenna Array with Low Sidelobe

A Ka-band dual-polarization magnetoelectric (ME) dipole antenna array based on three-dimensional (3D)-printed technology with low sidelobe level (SLL) is proposed in this paper. The metal posts and cross-slots are explored to build a novel subarray with 2 × 2-unit ME-dipoles as the basic element. Creatively, a square waveguide to cross-slots transition with a pyramid horn cavity structure is investigated to feed the ME-dipole subarray. Furthermore, two types of power-tapering corporate-feed networks with laminated structures are used to design an 8 × 8-unit low-SLL array. The fabricated array has a relative bandwidth (VSWR < 2) of 14.3% and 17.1%, with a realized gain higher than 25.8 dBi and 26.1 dBi for the H-pol. and V-pol., respectively. The maximum radiation efficiency for both arrays is 73.2%. The measured first sidelobe levels are less than –17.5 dB for both polarizations. With competitive performance and low fabrication cost, the proposed dual-polarization ME-dipole antenna array would be valuable for polarization-agile radar and communication systems.

Actively Q-switched Nd:YLF laser emitting at 908 nm

An actively Q-switched quasi-three-level Nd:YLF laser emitting at 908 nm, for the first time to our knowledge, was demonstrated. A RTP double-crystal scheme was used to realize electro-optical Q-switcher, and a L-shaped cavity structure was designed to suppress parasitic oscillation at 1047 nm. An 806 nm laser diode was used as the pump source with about 480 μs pulse width. With 46.4 mJ pump pulse energy input at repetition rate of 100 Hz, maximum output pulse energies of 0.84 mJ and 0.73 mJ were obtained with output transmissions of 6.5% and 11%, respectively. The corresponding peak pulse powers were up to 14.3 kW and 12.1 kW, and the output pulse widths were 58.6 ns and 60.3 ns. The central laser wavelengths were both at 908.3 nm with spectral bandwidth of over 0.7 nm.