scholarly journals Phytosterols and Cardiovascular Disease

2021 ◽  
Vol 23 (11) ◽  
Author(s):  
Umidakhon Makhmudova ◽  
P. Christian Schulze ◽  
Dieter Lütjohann ◽  
Oliver Weingärtner
Keyword(s):  
Lifestyle Modification ◽  
Plant Sterols ◽  
Blood Cholesterol ◽  
In Vivo Studies ◽  
Lipid Lowering ◽  
Food Supplementation ◽  
Lipid Lowering Therapy ◽  
Cholesterol Levels ◽  
Lower Blood Cholesterol ◽  
Lower Blood

Abstract Purpose of Review Coronary heart disease is the leading cause of mortality worldwide. Elevated blood cholesterol levels are not only the major but also the best modifiable cardiovascular risk factor. Lifestyle modifications which include a healthy diet are the cornerstone of lipid-lowering therapy. So-called functional foods supplemented with plant sterols lower blood cholesterol levels by about 10–15%. Recent Findings In the recent revision of the ESC/EAS dyslipidemia guideline 2019, plant sterols are recommended for the first time as an adjunct to lifestyle modification to lower blood cholesterol levels. However, the German Cardiac Society (DGK) is more critical of food supplementation with plant sterols and calls for randomized controlled trials investigating hard cardiovascular outcomes. An increasing body of evidence suggests that plant sterols per se are atherogenic. Summary This review discusses this controversy based on findings from in vitro and in vivo studies, clinical trials, and genetic evidence.

scholarly journals PENGARUH AIR REBUSAN DAUN MAMPELAS (Teteracera indica) TERHADAP KADAR KOLESTEROL DARAH MENCIT

2017 ◽  
Vol 4 (3) ◽  
pp. 197
Author(s):  
Dian Samitra ◽  
Zico Fakhrur Rozi
Keyword(s):  
Cholesterol Level ◽  
Blood Cholesterol ◽  
Blood Cholesterol Level ◽  
Cholesterol Levels ◽  
Traditional Remedies ◽  
Lower Blood Cholesterol ◽  
Lower Blood ◽  
Post Test ◽  
The Mean ◽  
The Difference

Tetracera indica Merr. locally known as Mampelas is commonly used in traditional remedies. It believed to have the potential to cure hypercholesterolemia. The potential use of this plant to lower blood cholesterol level was understudied; therefore this study aimed to determine the effect of the infusion of fresh leaves of Tetracera indica to the blood cholesterol levels of mice. This research was true experimental design, a post-test only design with nonequivalent (control) groups. This study used 25 male mice divided into five categories, i.e., P0 mice were administered with 0 g of infusion, P1 mice with 2 g infusion, P2 mice with 5 g infusion, P3 mice with 10 g infusion, and P4 mice without Tetracera indica infusion but 10 mg of simvastatin. The treatment in all categories were given continuously for seven days. The results showed the mean of the blood cholesterol levels were 169.4 ± 59.37 mg/dL in P0, 121.8 ± 7.62 mg/dL in P1, 136.2 ± 15.69 mg/dL in P2, 110.6 ± 37 , 01 mg/dL in P3 , and 179,0 ± 35,24 mg/dL in P4. Kruskal Wallis test was calculated to determine the difference of blood cholesterol level among all groups, and it reported p < 0.05. The results of this study showed that infusion of Tetracera indica leaf was significantly lowered the level of blood cholesterol in mice.

scholarly journals Recurring exon deletions in the HP (haptoglobin) gene contribute to lower blood cholesterol levels

2016 ◽  
Vol 48 (4) ◽  
pp. 359-366 ◽  
Author(s):  
Linda M Boettger ◽  
Rany M Salem ◽  
Robert E Handsaker ◽  
Gina M Peloso ◽  
Sekar Kathiresan ◽  
...  
Keyword(s):  
Blood Cholesterol ◽  
Cholesterol Levels ◽  
Lower Blood Cholesterol ◽  
Lower Blood ◽  
Haptoglobin Gene

scholarly journals Pengaruh Pemberian Ekstrak Buah Kelor (Moringa oleifera) Terhadap Penurunan Kadar Kolestrol Pada Darah Hewan Mencit (Mus musculus)

2017 ◽  
Vol 6 (1) ◽  
pp. 15
Author(s):  
Eva Zulviana ◽  
Nurdin Rahman ◽  
Supriadi Supriadi
Keyword(s):  
Moringa Oleifera ◽  
Positive Control ◽  
Negative Control ◽  
Effective Concentration ◽  
Blood Cholesterol ◽  
Fruit Extract ◽  
Treatment Groups ◽  
Cholesterol Levels ◽  
Lower Blood Cholesterol ◽  
Lower Blood

This study aimed to identify bioactive compounds of moringa (moringa oleifera) extracts and determine the effective concentration on lowering blood cholesterol levels of mice. The animals used were 15 male mice induced by propylthiouracil and fat food diet. The mice were divided randomly into 5 groups with different treatment groups. The first, the second, and the third treatments were given moringa extracts each with a concentration of 10, 20% and 40%. The fourth treatment group was given food fat diet and propiltiorasil as a positive control, and the fifth treatment was given standard food and distilled water as a negative control. Data were analyzed using a statistical analysis of variance (ANOVA) test followed by Duncan test. The results showed that moringa fruit extract contains alkaloids, saponins, flavonoids, and tannins. Moringa fruit extract can lower blood cholesterol levels of mice with the most effective concentration of 10%.

Community Intervention to Lower Blood Cholesterol: The "Know Your Cholesterol" Campaign in Pawtucket, Rhode Island

1986 ◽  
Vol 13 (2) ◽  
pp. 117-129 ◽  
Author(s):  
R. Craig Lefebvre ◽  
Gussie S. Peterson ◽  
Sarah A. McGraw ◽  
Thomas M. Lasater ◽  
Leslie Sennett ◽  
...  
Keyword(s):  
Rhode Island ◽  
Community Intervention ◽  
Blood Cholesterol ◽  
Lower Blood Cholesterol ◽  
Lower Blood
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